DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lute and Btbd3

DIOPT Version :9

Sequence 1:	NP_001262663.1	Gene:	lute / 42089	FlyBaseID:	FBgn0262871	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	NP_663509.2	Gene:	Btbd3 / 228662	MGIID:	2385155	Length:	530	Species:	Mus musculus

Alignment Length:	512	Identity:	314/512 - (61%)
Similarity:	381/512 - (74%)	Gaps:	20/512 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 GALNSSGSSSGGGAGSAGGISGSPTAFC-----LPSSSAAAAVAAI--SATPTSGSGSYVCSAGT 171
            |:..::.|..|||.||.|..|......|     |.:.......|.|  ...|.:.|.:.|    .
Mouse    29 GSKKANSSGGGGGGGSVGSGSSKLPPVCYEIITLKTKKKKKMAADIFPRKKPANSSSTTV----Q 89

  Fly   172 NWHFAAVAASNAIDTADPNWQASKATVLERNAAMFNNELMSDVKFIVGGEFDIDP--IQTIPAHK 234
            ..|...:..:|.|..  ||||....|:.||||.||||:||:||.|:||     .|  .|.:|.||
Mouse    90 QQHQHNLCNNNLIPA--PNWQGLYPTIRERNAVMFNNDLMADVHFVVG-----PPGGTQRLPGHK 147

  Fly   235 YILATGSSVFYAMFYGGLAENKQEIKVPDVEPTAFLTLLRYLYCDEIKLEPEHILATLYAAKKYI 299
            |:||.|||||:|||||.|||:|.||::|||||.|||.:|:|:|||||.|..:.:|||||||||||
Mouse   148 YVLAVGSSVFHAMFYGELAEDKDEIRIPDVEPAAFLAMLKYIYCDEIDLAADTVLATLYAAKKYI 212

  Fly   300 VPHLARACVNYLEVKLTAKNACLLLSQSRLFEEPELMQRCWEVIDAQAEMAVKSEDFVDIDLKTF 364
            ||||||||||:||..|:|||||:|||||.|||||:|.||||||||||||:|:|||.|.|||.:|.
Mouse   213 VPHLARACVNFLETSLSAKNACVLLSQSCLFEEPDLTQRCWEVIDAQAELALKSEGFCDIDFQTL 277

  Fly   365 ESILSRETLNCKEIHLFEAALNWAMNACEKMSIDDTPQNKRRLLGQALHLIRIPTMSLEEFANGV 429
            ||||.|||||.|||.:||||||||...|::..:..:.:|||::||:||:|||||||:|::||||.
Mouse   278 ESILRRETLNAKEIVVFEAALNWAEVECQRQDLALSIENKRKVLGKALYLIRIPTMALDDFANGA 342

  Fly   430 AQTGILSSQETIDMFLHFTAKMKPSLGFPTRSRAGLKTQVCHRFQSCAYRSNQWRYRGRCDSIQF 494
            ||:|:|:..||.|:||.:||..||.|.|.:::|.||..|.|||||||||||||||||||||||||
Mouse   343 AQSGVLTLNETNDIFLWYTASKKPELQFVSKARKGLVPQRCHRFQSCAYRSNQWRYRGRCDSIQF 407

  Fly   495 SVDRRIFIVGFGLYGSSTGAANYNVKIELKRLGRTLAENDTKFFSDGSSNTFHVFFENPIQIEPE 559
            :||:|:||.||||||||.|:|.|:.||||||.|..|.:|.:|:|||||||||.|:||.|:||||:
Mouse   408 AVDKRVFIAGFGLYGSSCGSAEYSAKIELKRQGVVLGQNLSKYFSDGSSNTFPVWFEYPVQIEPD 472

  Fly   560 CYYTASVILDGNELSFFGQEGMSEVLMGNVTFQFQCSSESTNGTGVQGGQIPELIFY 616
            .:|||||:|||||||:||||||:||..|.||.||||||:||||||||||||||||||
Mouse   473 TFYTASVVLDGNELSYFGQEGMTEVQCGKVTVQFQCSSDSTNGTGVQGGQIPELIFY 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lute	NP_001262663.1	BTB	204..311	CDD:279045	72/108 (67%)
		BTB	213..315	CDD:197585	68/103 (66%)
		BACK	321..427	CDD:197943	70/105 (67%)
		PHR	472..615	CDD:285277	110/142 (77%)
Btbd3	NP_663509.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..48		8/18 (44%)
		BTB	121..224	CDD:279045	72/107 (67%)
		BTB	129..228	CDD:197585	68/103 (66%)
		BACK	234..340	CDD:197943	70/105 (67%)
		PHR	385..528	CDD:285277	110/142 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833894
Domainoid	1	1.000	244	1.000	Domainoid score	I2191
eggNOG	1	0.900	-	-		E1_KOG2075
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8980
Inparanoid	1	1.050	612	1.000	Inparanoid score	I909
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46950
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000758
OrthoInspector	1	1.000	-	-		otm44245
orthoMCL	1	0.900	-	-		OOG6_100034
Panther	1	1.100	-	-	O	PTHR45774
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3806
SonicParanoid	1	1.000	-	-		X1485
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790