DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lute and tag-30

DIOPT Version :9

Sequence 1:	NP_001262663.1	Gene:	lute / 42089	FlyBaseID:	FBgn0262871	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	NP_001379158.1	Gene:	tag-30 / 178116	WormBaseID:	WBGene00006415	Length:	602	Species:	Caenorhabditis elegans

Alignment Length:	640	Identity:	226/640 - (35%)
Similarity:	337/640 - (52%)	Gaps:	70/640 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SSNNSSSTANNHGGHNPLNRLSLKSAGKRNQESMSHSQPNGGWINVETLNNGNGLLHSPPH---N 65
            ||.|....::...|  |.||          ::|....:|.    |.:::..|...|:....   |
Worm     2 SSENGVEVSDPEEG--PCNR----------RQSSGSCEPE----NSDSIFQGENQLYPSRRTAAN 50

  Fly    66 HQQQQQQQQRGGGGASPAGGGGGPSAAADHNIQITQPISAPSSPLASPGALNSSGSSSGGGAGSA 130
            |:.||||:.               |:..|....:....::.|.|.:|...::||.:||.|...:.
Worm    51 HEHQQQQKS---------------SSTLDLPANVLHEYASSSPPQSSSRHVHSSSTSSLGEVAAL 100

  Fly   131 GGISGSPTAFCLPSSSAAAAV-AAISATPTSGS-GSYVCSAGTNWHFAAVAASNAIDTADP---- 189
            .|     |.|.......|:.| .|::..|.|.: ..:|.:.................|..|
Worm   101 FG-----TRFPQDEGKQASNVEKAVNILPVSRNLAEHVSNLFAIGRKPVTIVQKKKPTNHPEENP 160

  Fly   190 ------NWQASKATVLERNAAMFNNELMSDVKFIVGGEFDIDPIQTIPAHKYILATGSSVFYAMF 248
                  .|||.|.|:.||...|:.||.::||.|:||.:   |..|.|||||::|:.||.||.|||
Worm   161 GARPLLGWQADKKTLRERIEHMYCNETLADVFFVVGID---DSRQRIPAHKFVLSIGSVVFDAMF 222

  Fly   249 YGGL----AENKQEIKVPDVEPTAFLTLLRYLYCDEIKLEPEHILATLYAAKKYIVPHLARACVN 309
            .|||    .|...||::|||||:|||.||::||.||:|:|.|.::.|||.||||.||.:.:.||.
Worm   223 NGGLTPKNTEEALEIELPDVEPSAFLALLKFLYSDEVKIEAESVMTTLYTAKKYAVPAMEKECVR 287

  Fly   310 YLEVKLTAKNACLLLSQSRLFEEPELMQRCWEVIDAQAEMAVKSEDFVDIDLKTFESILSRETLN 374
            :|:.:|...||.::|||::||:||:|||:|.||||.....|:..|.|.:|||.|...:|:|:.|.
Worm   288 FLKQRLVPDNAFMMLSQAKLFDEPDLMQKCLEVIDKNTLEALNGEGFTEIDLDTLCEVLTRDGLR 352

  Fly   375 CKEIHLFEAALNWAMNACEKMSIDDTPQNKRRLLGQALHLIRIPTMSLEEFANGVAQTGILSSQE 439
            .:||.||:|.|.||....|:..:.....::|.:|.:::.|||.|.|.::|||..|..:.|||.:|
Worm   353 IREIFLFQAVLRWAKFEAERRGMPANGDSRRAVLSRSIPLIRFPLMKIDEFALHVEPSHILSDRE 417

  Fly   440 TIDMFLHFTAKM--KPSLGFPTRSRAGLKT--QVCHRFQSCAYRSNQWRYRGRCDSIQFSVDRRI 500
            ...:|.:.....  :|.|.:..|.|..:.:  .|..|||..   .|:|.:.|..|.|:|.|||||
Worm   418 MNKIFKYLAVSPPDRPVLVYSDRPRCQISSTEYVVSRFQRI---ENRWGFCGTSDRIKFMVDRRI 479

  Fly   501 FIVGFGLYGSSTGAANYNVKIELKRLG--RTLAENDTKFFSDGSSNTFHVFFENPIQIEPECYYT 563
            |:|||||||:.:|...|..:|::...|  :||||:||.|..||:|....|.|:.|::|.|...|.
Worm   480 FVVGFGLYGAISGPHEYKTQIKIIHCGTNKTLAEHDTSFVCDGNSRPCRVCFKEPVEILPGITYI 544

  Fly   564 ASVILDGNELSFFGQEGMSEVLM--GNVTFQFQCSSESTNGTGVQGGQIPELIFY 616
            |:.::.|.: |::|.:|:..|..  .:|||||..::.:.|||.|:.|||||:|:|
Worm   545 AAALIRGPD-SYYGTKGLRRVSTHDSDVTFQFTYAAMNNNGTSVEDGQIPEIIYY 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lute	NP_001262663.1	BTB	204..311	CDD:279045	57/110 (52%)
		BTB	213..315	CDD:197585	55/105 (52%)
		BACK	321..427	CDD:197943	43/105 (41%)
		PHR	472..615	CDD:285277	62/146 (42%)
tag-30	NP_001379158.1	BTB_POZ_BTBD1_2	167..297	CDD:349590	66/132 (50%)
		BACK_BTBD1_like	293..387	CDD:350562	38/93 (41%)
		PHR	453..598	CDD:400388	63/148 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	119	1.000	Domainoid score	I3623
eggNOG	1	0.900	-	-		E1_KOG2075
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	337	1.000	Inparanoid score	I1409
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000758
OrthoInspector	1	1.000	-	-		oto18947
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3806
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.890