DRSC/TRiP Functional Genomics Resources

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Protein Alignment lute and BTBD11

DIOPT Version :9

Sequence 1:NP_001262663.1 Gene:lute / 42089 FlyBaseID:FBgn0262871 Length:735 Species:Drosophila melanogaster
Sequence 2:NP_001018082.1 Gene:BTBD11 / 121551 HGNCID:23844 Length:1104 Species:Homo sapiens


Alignment Length:620 Identity:130/620 - (20%)
Similarity:201/620 - (32%) Gaps:230/620 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    76 GGGGASPAGGGGGPSA--AADHNIQITQPISAPSSPLASPGALNSSGSSSGGGAGSAGGISGSPT 138
            |.|..|..|...||.|  |||...:      ||....||.||.:::.|:|||            :
Human   265 GSGSGSGPGPSSGPGAAPAADKERE------APGGGAASGGACSAASSASGG------------S 311

  Fly   139 AFCLPSSSAAAAVAAISATPTSGSGSYVCSAGTNWHFAAVAASNAIDTADPNWQASKATV--LER 201
            :.|.|.::|||||..              :|..|.|.....|.:         :|.|.||  ||.
Human   312 SCCAPPAAAAAAVPP--------------AAAANHHHHHHHALH---------EAPKFTVETLEH 353

  Fly   202 NAAMFNNE-----LMSDVKFIVGGE-----------------------------FDIDPIQTIPA 232
            ..   ||:     |:...:.::.|:                             |....::||  
Human   354 TV---NNDSEIWGLLQPYQHLICGKNASGVLCLPDSLNLHRDPQRSNKPGELPMFSQSELRTI-- 413

  Fly   233 HKYILAT--GS------SVFYAMFY-----------GGLAENKQEIKVPDVEPTAFLTLLRYLYC 278
            .:.:|||  ||      .|..||.:           |....:||....  .||.|..||..:::|
Human   414 EQSLLATRVGSIAELSDLVSRAMHHLQPLNAKHHGNGTPLHHKQGALY--WEPEALYTLCYFMHC 476

  Fly   279 DEIK-----LEPEHILATLYAAKKYIV-PHL---ARACVNYL-----------EVKLTAKNACLL 323
            .:::     :||..:  .|...:.::| |.|   .|..|.:.           :|:..|:   ||
Human   477 PQMEWENPNVEPSKV--NLQVERPFLVLPPLMEWIRVAVAHAGHRRSFSMDSDDVRQAAR---LL 536

  Fly   324 LSQSRLFEEPELMQR--CWEVIDAQAEMAVKSEDFVDIDLKTFESILSRETLNCKEIHLFEAALN 386
            |.....  ||..::.  |:        .|.:..|.|.|:.| |:..|....|||....|.:.|::
Human   537 LPGVDC--EPRQLRADDCF--------CASRKLDAVAIEAK-FKQDLGFRMLNCGRTDLVKQAVS 590

  Fly   387 WAMNACEKMSIDDTPQNKRRLLGQALHLIRIPTMSLEEFANGVAQTGILSSQETIDMFLHFTAKM 451
                                |||..    .|.||| |:....:....:...:..:.|.|...|.:
Human   591 --------------------LLGPD----GINTMS-EQGMTPLMYACVRGDEAMVQMLLDAGADL 630

  Fly   452 K----------PSLGFPTRSRAGLKTQVCHRFQSCAYRSNQWRYRGRCDSIQFSVDRRIFIVGFG 506
            .          ||:...||....|...|.|               |....:|..:|     .|..
Human   631 NVEVVSTPHKYPSVHPETRHWTALTFAVLH---------------GHIPVVQLLLD-----AGAK 675

  Fly   507 LYGS-STGAANYN---------------VKIELKR-----LG-------RTLAENDTKFFSD--- 540
            :.|| ..|..||:               |.:.|:|     :|       .|..:.|...||.   
Human   676 VEGSVEHGEENYSETPLQLAAAVGNFELVSLLLERGADPLIGTMYRNGISTTPQGDMNSFSQAAA 740

  Fly   541 -GSSNTFHVFFENPIQIEPECYYTASVILDGNELS 574
             |..|.|......|.:.:.:......::.:|.:|:
Human   741 HGHRNVFRKLLAQPEKEKSDILSLEEILAEGTDLA 775

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
luteNP_001262663.1 BTB 204..311 CDD:279045 32/168 (19%)
BTB 213..315 CDD:197585 30/169 (18%)
BACK 321..427 CDD:197943 26/107 (24%)
PHR 472..615 CDD:285277 23/135 (17%)
BTBD11NP_001018082.1 H2A 200..>244 CDD:305064
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 260..301 15/41 (37%)
Ank_4 <580..624 CDD:290365 11/68 (16%)
ANK 598..751 CDD:238125 34/173 (20%)
ANK 1 603..632 3/28 (11%)
ANK repeat 606..647 CDD:293786 5/40 (13%)
Ank_2 608..716 CDD:289560 22/127 (17%)
ANK repeat 649..680 CDD:293786 9/50 (18%)
ANK 2 649..678 8/48 (17%)
ANK repeat 682..712 CDD:293786 6/29 (21%)
ANK 3 687..716 4/28 (14%)
Ank_2 692..>752 CDD:289560 11/59 (19%)
ANK 4 730..759 7/28 (25%)
ANK 5 825..854
BTB 915..1018 CDD:279045
BTB 924..1022 CDD:197585
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165143719
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.840

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