DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lute and BTBD9

DIOPT Version :9

Sequence 1:	NP_001262663.1	Gene:	lute / 42089	FlyBaseID:	FBgn0262871	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	NP_001092742.1	Gene:	BTBD9 / 114781	HGNCID:	21228	Length:	612	Species:	Homo sapiens

Alignment Length:	419	Identity:	108/419 - (25%)
Similarity:	161/419 - (38%)	Gaps:	90/419 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   200 ERNAAMFNNELMSDVKFIVGGEFDIDPIQTIPAHKYILATGSSVFYAMFYGGLAENKQEIKVP-- 262
            |...|:...|...||.|:|       ..:..|||:.|||.....|.|:.|||:.|::.|.::|
Human    24 EHIGALLIGEEYGDVTFVV-------EKKRFPAHRVILAARCQYFRALLYGGMRESQPEAEIPLQ 81

  Fly   263 DVEPTAFLTLLRYLYCDEIKL--EPEHILAT-LYAAKKYIVPHLARACVNYLEVKLTAKNACLLL 324
            |....||..||:|:|.....|  |.|.:|.. |..|.||..|.|..:...||...|..:|.|:..
Human    82 DTTAEAFTMLLKYIYTGRATLTDEKEEVLLDFLSLAHKYGFPELEDSTSEYLCTILNIQNVCMTF 146

  Fly   325 SQSRLFEEPELMQRCWEVIDAQAEMAVKSEDFVDIDLKTFESILSRETLNCKEIHLFEAALNWAM 389
            ..:.|:..|:|...|...:|..|:..:.||.|:.:......:|:.|::....|..:|.|.|||
Human   147 DVASLYSLPKLTCMCCMFMDRNAQEVLSSEGFLSLSKTALLNIVLRDSFAAPEKDIFLALLNW-- 209

  Fly   390 NACEKMSIDDTPQNKRRLLGQALHLIRIPTMSLEEFANGVAQTGILSSQETIDMFLHFTAKMKPS 454
              |:        .|.:....:.:..:|:|.|||.|..|.|..:|:||....:|
Human   210 --CK--------HNSKENHAEIMQAVRLPLMSLTELLNVVRPSGLLSPDAILD------------ 252

  Fly   455 LGFPTRSRAGLKTQVCHRFQSCAYRSNQWRYRGRCDSIQFSVDRRIFIVGFGLYGSSTGAANYNV 519
             ....||.:               |.....|||     ....:..|..:   .||:..      |
Human   253 -AIKVRSES---------------RDMDLNYRG-----MLIPEENIATM---KYGAQV------V 287

  Fly   520 KIELKRLGRTLAENDTKFFSDGSSNTFHVFFENPIQ------IE-----PECYYTASVIL---DG 570
            |.|||   ..|.:.||:.:     :..|.|..:||.      ||     |.......::|   |.
Human   288 KGELK---SALLDGDTQNY-----DLDHGFSRHPIDDDCRSGIEIKLGQPSIINHIRILLWDRDS 344

  Fly   571 NELSFFGQEGMSEVLMGNVT--FQFQCSS 597
            ...|:|.:..|.|:....|.  .|:.|.|
Human   345 RSYSYFIEVSMDELDWVRVIDHSQYLCRS 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lute	NP_001262663.1	BTB	204..311	CDD:279045	37/111 (33%)
		BTB	213..315	CDD:197585	37/106 (35%)
		BACK	321..427	CDD:197943	26/105 (25%)
		PHR	472..615	CDD:285277	32/142 (23%)
BTBD9	NP_001092742.1	BTB_POZ_BTBD9	14..133	CDD:349596	38/115 (33%)
		BACK_BTBD9	137..235	CDD:350518	27/109 (25%)
		F5_F8_type_C	292..405	CDD:366285	21/90 (23%)
		F5_F8_type_C	445..546	CDD:366285
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	560..612
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143721
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840