DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lute and btbd6a

DIOPT Version :9

Sequence 1:	NP_001262663.1	Gene:	lute / 42089	FlyBaseID:	FBgn0262871	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	NP_001108397.1	Gene:	btbd6a / 100141360	ZFINID:	ZDB-GENE-080218-26	Length:	525	Species:	Danio rerio

Alignment Length:	527	Identity:	296/527 - (56%)
Similarity:	369/527 - (70%)	Gaps:	45/527 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 IQITQPISAPSSPLASPGALNSSGSSSGGGAGSAGGISGSPTAFCLPSSS-----AAAAVAAISA 156
            :.:.:.::|...|::....|..||:                ....||...     .:...|:|:.
Zfish    36 LSLKKRMAAELYPVSDHATLQKSGA----------------VMLSLPEKKRNVEPVSQTTASIAT 84

  Fly   157 TPTSGSGSYVCSAGTNWHFAAVAASNAIDTADPNWQASKATVLERNAAMFNNELMSDVKFIVG-- 219
            |||:...               ..:|.::.  |:|.::..|:.||||.|||||.|:||.||||
Zfish    85 TPTTEQN---------------INNNNVEI--PSWHSAHPTLRERNALMFNNEQMADVHFIVGPP 132

  Fly   220 GEFDIDPIQTIPAHKYILATGSSVFYAMFYGGLAENKQEIKVPDVEPTAFLTLLRYLYCDEIKLE 284
            ||     .|.:|||||:||.|||||.|||||.|||...:|.:|||||.|||.||:|:|.|||:|.
Zfish   133 GE-----SQRVPAHKYVLAVGSSVFCAMFYGDLAEGDSDIHIPDVEPAAFLILLKYMYSDEIELA 192

  Fly   285 PEHILATLYAAKKYIVPHLARACVNYLEVKLTAKNACLLLSQSRLFEEPELMQRCWEVIDAQAEM 349
            |:.:||||||||||:|..||||||.:||..|.|:|||:|||||||||||||.||||||||||||:
Zfish   193 PDTVLATLYAAKKYLVSALARACVGFLETSLEARNACVLLSQSRLFEEPELTQRCWEVIDAQAEL 257

  Fly   350 AVKSEDFVDIDLKTFESILSRETLNCKEIHLFEAALNWAMNACEKMSIDDTPQNKRRLLGQALHL 414
            |::||.|.:|||.|.||||.|||||.||..:|:|.|.||...|.:..:..|.||:|.:||:||||
Zfish   258 ALRSEGFSEIDLPTLESILHRETLNVKESVVFQAVLGWADAECRRQGLSPTSQNQRSVLGKALHL 322

  Fly   415 IRIPTMSLEEFANGVAQTGILSSQETIDMFLHFTAKMKPSLGFPTRSRAGLKTQVCHRFQSCAYR 479
            :|:|:|:|:|||:|.||..||:.:||..:||.:||..|||||||..:|.||..|.||||||.|||
Zfish   323 VRLPSMTLQEFADGAAQVDILTLEETHSIFLWYTAATKPSLGFPVNAREGLTAQRCHRFQSSAYR 387

  Fly   480 SNQWRYRGRCDSIQFSVDRRIFIVGFGLYGSSTGAANYNVKIELKRLGRTLAENDTKFFSDGSSN 544
            |||||||||||||||:||:|:||.|.||||||.|.|.|:|:|||||.|..||:|.|||.|||||:
Zfish   388 SNQWRYRGRCDSIQFAVDKRVFIAGLGLYGSSGGKAEYSVRIELKRQGVLLAQNLTKFVSDGSSS 452

  Fly   545 TFHVFFENPIQIEPECYYTASVILDGNELSFFGQEGMSEVLMGNVTFQFQCSSESTNGTGVQGGQ 609
            ||.|:||:|:|:|.:.:||.|.:|||:|||:||||||:||..|.|||||||||:|||||||||||
Zfish   453 TFPVWFEHPVQVEQDAFYTVSAVLDGSELSYFGQEGMTEVQCGKVTFQFQCSSDSTNGTGVQGGQ 517

  Fly   610 IPELIFY 616
            |||||||
Zfish   518 IPELIFY 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lute	NP_001262663.1	BTB	204..311	CDD:279045	70/108 (65%)
		BTB	213..315	CDD:197585	66/103 (64%)
		BACK	321..427	CDD:197943	67/105 (64%)
		PHR	472..615	CDD:285277	105/142 (74%)
btbd6a	NP_001108397.1	BTB	116..219	CDD:279045	70/107 (65%)
		BTB	124..223	CDD:197585	66/103 (64%)
		BACK	229..335	CDD:197943	67/105 (64%)
		PHR	380..523	CDD:285277	105/142 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576622
Domainoid	1	1.000	246	1.000	Domainoid score	I2128
eggNOG	1	0.900	-	-		E1_KOG2075
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	599	1.000	Inparanoid score	I922
OMA	1	1.010	-	-		QHG46950
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000758
OrthoInspector	1	1.000	-	-		otm25538
orthoMCL	1	0.900	-	-		OOG6_100034
Panther	1	1.100	-	-	O	PTHR45774
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1485
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.760