Protein Alignment Brf and BRF1

DIOPT Version :9

• Sequence 1: NP_001163636.1
• Gene: Brf / 42087
• FlyBaseID: FBgn0038499
• Length: 662
• Species: Drosophila melanogaster
• Sequence 2: NP_011762.1
• Gene: BRF1 / 853161
• SGDID: S000003478
• Length: 596
• Species: Saccharomyces cerevisiae
• Alignment Length: 617
• Identity: 190/617 - (30%)
• Similarity: 300/617 - (48%)
• Gaps: 114/617 - (18%)

  Fly     7 CRNCGSNEIEED--NARGDRVCMNCGSVLEDSLIVSEVQFEEVGHGAAAI-GQFVSAESSGGATN 68
            |:||...|.|.|  ||..|.||..||.|.||:.|||||.|.|...|||.: |.|:.|..|..|
Yeast     4 CKNCHGTEFERDLSNANNDLVCKACGVVSEDNPIVSEVTFGETSAGAAVVQGSFIGAGQSHAA-- 66

  Fly    69 YGYGKFQVGSGTESREVTIKKAKKDITLLCQQLQLSQHYADTALNFFKMALGRHLTRGRKSTHIY 133
                 |...|..||||.|:..|::.:..:...|.:.::..|.|..::|:||..:..:||:|.::.
Yeast    67 -----FGGSSALESREATLNNARRKLRAVSYALHIPEYITDAAFQWYKLALANNFVQGRRSQNVI 126

  Fly   134 AACVYMTCRTEGTSHLLIDISDVQQICSYELGRTYLKLSHALCI-NIPSLDPCLYIMRFANRLQL 197
            |:|:|:.||.|.|.|:|||.|...|:..|.:|.|:||:...|.| .:|..||.|:|..||.:|.|
Yeast   127 ASCLYVACRKEKTHHMLIDFSSRLQVSVYSIGATFLKMVKKLHITELPLADPSLFIQHFAEKLDL 191

  Fly   198 GAKTHEVSMTALRIVQRMKKDCMHSGRRPTGLCGAALLIAARMHDFSRTMLDVIGVVKIHESTLR 262
            ..|..:|...|:::.|||.||.|..||||.|:.||.:|:|.||::..||..:::.|..:.|.||:
Yeast   192 ADKKIKVVKDAVKLAQRMSKDWMFEGRRPAGIAGACILLACRMNNLRRTHTEIVAVSHVAEETLQ 256

  Fly   263 KRLSEFAETPSGGLTLEEFMTVDLE-REQDPPSFKAARKKDRERIKD------------------ 308
            :||:||..|.:..|::::|...|:| .|..||||...|||:| :|||
Yeast   257 QRLNEFKNTKAAKLSVQKFRENDVEDGEARPPSFVKNRKKER-KIKDSLDKEEMFQTSEEALNKN 320

  Fly   309 ------MGEHELTELQKEIDAHLEKDLGKYSNSVYRQLTKGKGLSPLSSPSTPNSSSEKDI---- 363
                  :||.||:  .||:..:|:    ::|....|.:.:.|..:.:...:..:..||.:.
Yeast   321 PILTQVLGEQELS--SKEVLFYLK----QFSERRARVVERIKATNGIDGENIYHEGSENETRKRK 379

  Fly   364 --ELEESRQFIE------QSNAEVIKELIAK-NEDVKKSEPGGLVAGIEGLRPDIEAIC------ 413
              |:....:.:|      :...|.:|::..| :|:.|::|.|.....|:|...:.:..|
Yeast   380 LSEVSIQNEHVEGEDKETEGTEEKVKKVKTKTSEEKKENESGHFQDAIDGYSLETDPYCPRNLHL 444

  Fly   414 -RVTQSDLEDVEKAKQPQEQELITDDLNDDELDQYVLTEEESVAKLEMWKNLNAEYLQEQKERDE 477
             ..|.:.|..|  :..|...|    |::|:||:.::|.||.|..|..:|..|||::|.||:.:
Yeast   445 LPTTDTYLSKV--SDDPDNLE----DVDDEELNAHLLNEEASKLKERIWIGLNADFLLEQESK-- 501

  Fly   478 RLAKERE--EGKPERKKRKPRKK----------------VIGPSS-------------------- 504
            ||.:|.:  .|....||::.|::                .||..|
Yeast   502 RLKQEADIATGNTSVKKKRTRRRNNTRSDEPTKTVDAAAAIGLMSDLQDKSGLHAALKAAEESGD 566

  Fly   505 -TAGEAIEKMLQEKKISSKINYEILKTLTDGM 535
             |..::::.|||:...|.||||:.:    ||:
Yeast   567 FTTADSVKNMLQKASFSKKINYDAI----DGL 594

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Brf	NP_001163636.1	TF_Zn_Ribbon	5..44	CDD:285471	21/38 (55%)
		SUA7	6..270	CDD:224323	107/266 (40%)
		CYCLIN	108..164	CDD:294043	22/55 (40%)
		CYCLIN	183..268	CDD:238003	36/84 (43%)
		BRF1	441..531	CDD:285040	34/128 (27%)
BRF1	NP_011762.1	SUA7	1..261	CDD:224323	105/263 (40%)
		BRF1	463..595	CDD:400202	38/142 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346733
Domainoid	1	1.000	65	1.000	Domainoid score	I2413
eggNOG	1	0.900	-	-		E1_COG1405
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1161
Inparanoid	1	1.050	254	1.000	Inparanoid score	I648
Isobase	1	0.950	-	0	Normalized mean entropy	S1818
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002717
OrthoInspector	1	1.000	-	-		oto100245
orthoMCL	1	0.900	-	-		OOG6_101494
Panther	1	1.100	-	-	LDO	PTHR11618
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1499
SonicParanoid	1	1.000	-	-		X2091
TreeFam	1	0.960	-	-
	15	14.730