DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Brf and MEE65

DIOPT Version :9

Sequence 1:	NP_001163636.1	Gene:	Brf / 42087	FlyBaseID:	FBgn0038499	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_178237.3	Gene:	MEE65 / 814656	AraportID:	AT2G01280	Length:	548	Species:	Arabidopsis thaliana

Alignment Length:	700	Identity:	169/700 - (24%)
Similarity:	283/700 - (40%)	Gaps:	208/700 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 CRNCGSNEIEEDNARGDRVCMNCGSVLEDSLIVSEVQFEEVGHGAAAIGQFVSAESSGGATNYGY 71
            |::|..|..:.....|...|..||.:||:....::|.|.:     .|.||..:..:|.|
plant     4 CKHCAKNVPKIRPFDGGLACDLCGRILENFNFSTDVTFVK-----NAAGQVCNIVTSVG------ 57

  Fly    72 GKFQVGSGTESREVTIKKAKKDITLLCQQLQLSQH---YADTALNFFKMALGRHLTRGRKSTHIY 133
                   .:.||:...:||..::..|...|.:...   ..|.|..|::.|:.::.|:||::..:.
plant    58 -------NSSSRDRRRRKAIDELRNLKDALGIGDERDDVVDMAAVFYEAAMDQNFTKGRRAELVQ 115

  Fly   134 AACVYMTCRTEGTSHLLIDISDVQQICSYELGRTYLKLSHALCI----NIPSL-DPCLYIMRFAN 193
            ::|:|:.|     |:|.:.:        ||||..||:|...|.:    |...| ||.::|.||.|
plant   116 SSCLYLAC-----SYLRVSV--------YELGSVYLQLCEMLYLVQNKNYEELVDPSIFIPRFTN 167

  Fly   194 RLQLG--AKTHEVSMTALRIVQRMKKDCMHSGRRPTGLCGAALLIAARMHDFSRTMLDVIGVVKI 256
            .|..|  ||..:|:.||..|:..||:|.:.:||:|:|:||||:.:||..|....:..|:..||.:
plant   168 SLLKGAHAKAKDVANTAKNIISSMKRDWIQTGRKPSGICGAAIYMAALSHGIMYSRADIAKVVHM 232

  Fly   257 HESTLRKRLSEFAETPSGGLTLEEFMTVDLEREQD---PPSFKAARKKDRERIKDMGEHELTELQ 318
            .|:|:.|||:|||.|.:|.||::|     |:..::   ..:|......|:..:.  .:|
plant   233 CEATITKRLNEFANTEAGSLTVDE-----LDESEEILRKETFTPRPNSDKGVVN--CKH------ 284

  Fly   319 KEIDAHLEKDLGKYSNSVYRQ------LTKGKGLSPLSSPSTPNSSSEKDIE---LEESRQFIEQ 374
                    |||.::...:.:.      :..| |:...|.|.....:.::.:|   .||:...|..
plant   285 --------KDLKRFGYGLCKSCHDDFIIISG-GVVGGSDPPAYQRAEKERMEKAAREENEGGIGN 340

  Fly   375 SNAEVIKELIAKNEDVKK-SEPG-GLVAGIEGLRPDIEAICRVTQSDLEDVEKAKQPQEQELITD 437
            .|.:   |.:..::..|| ||.| |...|.|                    ..|:...|.::.:|
plant   341 LNHD---EQVNVSKRAKKCSEKGEGETYGGE--------------------RHAEYSDESDICSD 382

  Fly   438 DLNDDELDQYVLTEEESVAKLEMWKNLNAEYLQEQKERDERL--------------------AKE 482
            | :|.|::..:|.|:|:..|...|...|.:||:||.|::..|                    |..
plant   383 D-DDSEVEHVLLGEDETRLKTTAWNLQNKDYLEEQAEKEAALKAANCPEDARNLVEASKAAVANS 446

  Fly   483 REEGKPERKKRKPRKKVIGPSSTAGEAIEKMLQEKKISSKIN-YEILKTLTDGMGGLTDDSPTTS 546
            |:|   :|:||....|...||:||.||.....|      ::| :.:|..|.|           ||
plant   447 RKE---KRRKRAEEAKNAPPSATATEASYTETQ------RVNQHHVLDELLD-----------TS 491

  Fly   547 ADTKPSTLEELKHQPVIVEEGPVASKSRGNRAAYDLPGPSRKRPKLEVGLPVSKAADVEQAETKP 611
                                                  |::|:|:.|.         |.:.:.:.
plant   492 --------------------------------------PTQKKPRTET---------VTEKKKEE 509

  Fly   612 AVVVEADDLDED-----ADDPDVEPEAEPEATLQDMLNTGGDDDEFGYGF 656
            ..:||.::.:||     ||:...|.|.|              ::|.||.|
plant   510 HEIVEDEEDEEDYAAPHADENFYEDEVE--------------EEENGYDF 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Brf	NP_001163636.1	TF_Zn_Ribbon	5..44	CDD:285471	10/36 (28%)
		SUA7	6..270	CDD:224323	82/272 (30%)
		CYCLIN	108..164	CDD:294043	13/55 (24%)
		CYCLIN	183..268	CDD:238003	36/86 (42%)
		BRF1	441..531	CDD:285040	30/110 (27%)
MEE65	NP_178237.3	SUA7	<68..243	CDD:224323	62/187 (33%)
		CYCLIN	69..>129	CDD:238003	15/64 (23%)
		CYCLIN	178..237	CDD:294043	22/58 (38%)
		BRF1	387..>470	CDD:285040	24/85 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	60	1.000	Domainoid score	I3851
eggNOG	1	0.900	-	-		E1_COG1405
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	192	1.000	Inparanoid score	I1367
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D412601at2759
OrthoFinder	1	1.000	-	-		FOG0002717
OrthoInspector	1	1.000	-	-		otm2628
orthoMCL	1	0.900	-	-		OOG6_101494
Panther	1	1.100	-	-	O	PTHR11618
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2091
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.830