DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Brf and BRF1

DIOPT Version :9

Sequence 1:	NP_001163636.1	Gene:	Brf / 42087	FlyBaseID:	FBgn0038499	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_001510.2	Gene:	BRF1 / 2972	HGNCID:	11551	Length:	677	Species:	Homo sapiens

Alignment Length:	701	Identity:	305/701 - (43%)
Similarity:	424/701 - (60%)	Gaps:	66/701 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TGLKCRNCGSNEIEEDNARGDRVCMNCGSVLEDSLIVSEVQF-EEVGHGAAAIGQFVSAESSGGA 66
            ||..||.||..:||.|.||||.||..|||||||::||||||| |..|.|::|:|||||.:.:|..
Human     2 TGRVCRGCGGTDIELDAARGDAVCTACGSVLEDNIIVSEVQFVESSGGGSSAVGQFVSLDGAGKT 66

  Fly    67 TNYGYGKFQVGSGTESREVTIKKAKKDITLLCQQLQLSQHYADTALNFFKMALGRHLTRGRKSTH 131
            ...| |.|.|..|.|||..|::..::.|..|..||||:||..|||.||||||:.||||||||..|
Human    67 PTLG-GGFHVNLGKESRAQTLQNGRRHIHHLGNQLQLNQHCLDTAFNFFKMAVSRHLTRGRKMAH 130

  Fly   132 IYAACVYMTCRTEGTSHLLIDISDVQQICSYELGRTYLKLSHALCINIPSLDPCLYIMRFANRLQ 196
            :.|||:|:.||||||.|:|:|:||:.|:..|.||:|:|.|:..||||.|::||||||.|||:.|:
Human   131 VIAACLYLVCRTEGTPHMLLDLSDLLQVNVYVLGKTFLLLARELCINAPAIDPCLYIPRFAHLLE 195

  Fly   197 LGAKTHEVSMTALRIVQRMKKDCMHSGRRPTGLCGAALLIAARMHDFSRTMLDVIGVVKIHESTL 261
            .|.|.|||||||||::||||:|.||:||||:||||||||:|||||||.||:.:||.|||:.||||
Human   196 FGEKNHEVSMTALRLLQRMKRDWMHTGRRPSGLCGAALLVAARMHDFRRTVKEVISVVKVCESTL 260

  Fly   262 RKRLSEFAETPSGGLTLEEFMTVDLEREQDPPSFKAARKKDR-ERIKDMGEHELTELQKEIDAHL 325
            ||||:||.:||:..||::|||.:|||.|.||||:.|.::|.| ::::.:...:|.|::.||.::.
Human   261 RKRLTEFEDTPTSQLTIDEFMKIDLEEECDPPSYTAGQRKLRMKQLEQVLSKKLEEVEGEISSYQ 325

  Fly   326 EKDLGKYSNSVYRQLTKGKGLSPLSSP-STPNSSS----EKDIELEESRQFIEQSNAEVIKELI- 384
            :....:..||  |...|| ||:.|:.. ||.:::|    |:|.|.||........|.::.:||:
Human   326 DAIEIELENS--RPKAKG-GLASLAKDGSTEDTASSLCGEEDTEDEELEAAASHLNKDLYRELLG 387

  Fly   385 ---AKNEDVKKSEPGGL------------VAGIEGLRPDIEAICRVTQSDLEDVEKAKQPQEQEL 434
               ..:|.....|.||.            .|...|:...|........||.:|..     .:.||
Human   388 GAPGSSEAAGSPEWGGRPPALGSLLDPLPTAASLGISDSIRECISSQSSDPKDAS-----GDGEL 447

  Fly   435 ITDDLNDDELDQYVLTEEESVAKLEMWKNLNAEYLQEQKERDERLAKERE-----EGKPER--KK 492
            ....::|.|:|:|:|.|.|:..|.|:|...|||||:||:|::.|:|||:|     |.||::  |:
Human   448 DLSGIDDLEIDRYILNESEARVKAELWMRENAEYLREQREKEARIAKEKELGIYKEHKPKKSCKR 512

  Fly   493 RKPRKKVIGPSSTAGEAIEKMLQEKKISSKINYEILKTLTDGMGG---LTDDSPTTSADTKPSTL 554
            |:|.:     :|||.|||||||::|||||||||.:|:.|:...||   ..|..|..||..:..:
Human   513 REPIQ-----ASTAREAIEKMLEQKKISSKINYSVLRGLSSAGGGSPHREDAQPEHSASARKLS- 571

  Fly   555 EELKHQPVIVEEG--PVASKSRGNRAAYDLPGPSRKRPKLEVGLPVSKAADVEQAETKPAVVVEA 617
               :.:......|  ||.|..:..|...... |::|....|..||.|.....|.|..: ||:||:
Human   572 ---RRRTPASRSGADPVTSVGKRLRPLVSTQ-PAKKVATGEALLPSSPTLGAEPARPQ-AVLVES 631

  Fly   618 DDL----DEDAD--DPDVEPEAEPEATLQDMLNTGGDDDEFGYGFDEEEEY 662
            ..:    ||:||  :|| |.:.||..:...|:.:    :::|...||::.|
Human   632 GPVSYHADEEADEEEPD-EEDGEPCVSALQMMGS----NDYGCDGDEDDGY 677

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Brf	NP_001163636.1	TF_Zn_Ribbon	5..44	CDD:285471	25/38 (66%)
		SUA7	6..270	CDD:224323	163/264 (62%)
		CYCLIN	108..164	CDD:294043	35/55 (64%)
		CYCLIN	183..268	CDD:238003	62/84 (74%)
		BRF1	441..531	CDD:285040	49/96 (51%)
BRF1	NP_001510.2	SUA7	4..266	CDD:224323	161/262 (61%)
		Repetitive region	91..172		48/80 (60%)
		Repetitive region	185..269		61/83 (73%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	340..368		11/28 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	385..413		5/27 (19%)
		BRF1	450..546	CDD:311606	49/100 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	501..521		7/24 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	544..653		31/115 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160320
Domainoid	1	1.000	110	1.000	Domainoid score	I6314
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1161
Inparanoid	1	1.050	482	1.000	Inparanoid score	I1469
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53031
OrthoDB	1	1.010	-	-		D364940at33208
OrthoFinder	1	1.000	-	-		FOG0002717
OrthoInspector	1	1.000	-	-		oto91469
orthoMCL	1	0.900	-	-		OOG6_101494
Panther	1	1.100	-	-	LDO	PTHR11618
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1499
SonicParanoid	1	1.000	-	-		X2091
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.940