DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Brf and Gtf2b

DIOPT Version :9

Sequence 1:NP_001163636.1 Gene:Brf / 42087 FlyBaseID:FBgn0038499 Length:662 Species:Drosophila melanogaster
Sequence 2:NP_663521.1 Gene:Gtf2b / 229906 MGIID:2385191 Length:316 Species:Mus musculus


Alignment Length:279 Identity:68/279 - (24%)
Similarity:120/279 - (43%) Gaps:28/279 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 CRNCGSNEIEEDNARGDRVCMNCGSVLEDSLI--------------------VSEVQFEEVGHG- 50
            |.|.....:.||...||.:|..||.|:.|.:|                    |.:.|...:..| 
Mouse    15 CPNHPDAILVEDYRAGDMICPECGLVVGDRVIDVGSEWRTFSNDKATKDPSRVGDSQNPLLSDGD 79

  Fly    51 -AAAIGQFVSAESSGGATNYGYGKFQVGSGTESREVTIKKAKKDITLLCQQLQLSQHYADTALNF 114
             :..||:...|.|   ...:|..|:|......|.:..:..|.|:||.:..::.|.::..|...|.
Mouse    80 LSTMIGKGTGAAS---FDEFGNSKYQNRRTMSSSDRAMMNAFKEITTMADRINLPRNIVDRTNNL 141

  Fly   115 FKMALGRHLTRGRKSTHIYAACVYMTCRTEGTSHLLIDISDVQQICSYELGRTYLKLSHALCINI 179
            ||....:...:||.:..|.:||:|:.||.||......:|..|.:|...|:||.:..:..||..::
Mouse   142 FKQVYEQKSLKGRANDAIASACLYIACRQEGVPRTFKEICAVSRISKKEIGRCFKLILKALETSV 206

  Fly   180 PSLDPCLYIMRFANRLQLGAKTHEVSMTALRIVQRMKKDCMHSGRRPTGLCGAALLIAARMHDFS 244
            ..:....::.||.:.|.|   ..:|.|.|..|.::..:..:..||.|..:..||:.:|::.....
Mouse   207 DLITTGDFMSRFCSNLCL---PKQVQMAATHIARKAVELDLVPGRSPISVAAAAIYMASQASAEK 268

  Fly   245 RTMLDVIGVVKIHESTLRK 263
            ||..::..:..:.:.|:|:
Mouse   269 RTQKEIGDIAGVADVTIRQ 287

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BrfNP_001163636.1 TF_Zn_Ribbon 5..44 CDD:285471 13/56 (23%)
SUA7 6..270 CDD:224323 68/279 (24%)
CYCLIN 108..164 CDD:294043 17/55 (31%)
CYCLIN 183..268 CDD:238003 18/81 (22%)
BRF1 441..531 CDD:285040
Gtf2bNP_663521.1 SUA7 14..290 CDD:224323 68/279 (24%)
Repetitive region 124..200 21/75 (28%)
Core promoter DNA-binding. /evidence=ECO:0000250|UniProtKB:Q00403 189..193 1/3 (33%)
Repetitive region 218..294 17/73 (23%)
Necessary for TATA box-bound TBP complex formation. /evidence=ECO:0000250|UniProtKB:Q00403 244..316 10/44 (23%)
Core promoter DNA-binding. /evidence=ECO:0000250|UniProtKB:Q00403 249..252 1/2 (50%)
Core promoter DNA-binding. /evidence=ECO:0000250|UniProtKB:Q00403 283..286 1/2 (50%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1405
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

Return to query results.
Submit another query.