DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Brf and brf1

DIOPT Version :9

Sequence 1:	NP_001163636.1	Gene:	Brf / 42087	FlyBaseID:	FBgn0038499	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_001182550.1	Gene:	brf1 / 100170638	XenbaseID:	XB-GENE-946065	Length:	665	Species:	Xenopus tropicalis

Alignment Length:	699	Identity:	305/699 - (43%)
Similarity:	428/699 - (61%)	Gaps:	82/699 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 CRNCGSNEIEEDNARGDRVCMNCGSVLEDSLIVSEVQFEEVGHG-AAAIGQFVSAESSGGATNYG 70
            |:|||..:|:.|.||||.||..|||||||::|||||||.|...| ::|:|||||:|.||...:.|
Frog     6 CKNCGCTDIDVDAARGDAVCTGCGSVLEDNIIVSEVQFVEGAGGISSAVGQFVSSECSGKTPSLG 70

  Fly    71 YGKFQVGSGTESREVTIKKAKKDITLLCQQLQLSQHYADTALNFFKMALGRHLTRGRKSTHIYAA 135
            .| |....|.|||..|::..|:.|..|..||||::|..|||.||||||:.:|||||||.||:.||
Frog    71 EG-FYTSVGKESRAQTLQNGKRQIHNLGVQLQLNKHCLDTAFNFFKMAVSKHLTRGRKMTHVIAA 134

  Fly   136 CVYMTCRTEGTSHLLIDISDVQQICSYELGRTYLKLSHALCINIPSLDPCLYIMRFANRLQLGAK 200
            |:|:.||||||.|:|:|:||:.|:..|.||:|:|.|:..||||.|::||||||.|||:.|:.|.|
Frog   135 CLYLVCRTEGTPHMLLDLSDLLQVNVYVLGKTFLLLARELCINAPAIDPCLYIPRFAHLLEFGDK 199

  Fly   201 THEVSMTALRIVQRMKKDCMHSGRRPTGLCGAALLIAARMHDFSRTMLDVIGVVKIHESTLRKRL 265
            .|||||||||:|||||:|.||:||||:||||||||:|:|||||.||:.:||.|||:.||||||||
Frog   200 NHEVSMTALRLVQRMKRDWMHTGRRPSGLCGAALLVASRMHDFRRTIKEVIRVVKVCESTLRKRL 264

  Fly   266 SEFAETPSGGLTLEEFMTVDLEREQDPPSFKAARKKDRERIKDMGEHELTELQKEIDAHLEKDLG 330
            :||.:||:..||::|||.:|||:|.|||||.|.::|  .:|:.:.:    ||.|::| .:|.::.
Frog   265 TEFEDTPTSQLTIDEFMKIDLEQECDPPSFTAGQRK--VKIQQLEQ----ELAKKLD-EVEGEIS 322

  Fly   331 KYSNSVYRQL----TKGKGL--SPLSSPSTPNSSS-----EKDIELEESRQFIEQSNAEVIKEL- 383
            .|.:.:..:|    .|.||:  |...:.|..|:||     :.|.:||.:...:   |.:...||
Frog   323 SYQDEIENELESSRPKPKGIYASYAKNGSEDNTSSILAEEDDDEDLEAAANHL---NKDFYSELA 384

  Fly   384 ------IAKNEDVK----KSEPGGL-VAGIEGLRPDIEAICRVTQSDLEDVEKAKQPQEQELITD 437
                  |.....||    :|..|.| .|...|:...|:....:.:.     ||:....:.||..:
Frog   385 NDTSKGICYEHTVKPLPIESLLGPLPTAASLGITDSIKECIAINEQ-----EKSDNAGDGELDLN 444

  Fly   438 DLNDDELDQYVLTEEESVAKLEMWKNLNAEYLQEQKERDERLAKEREEG-KPERKKRKPRKKVIG 501
            .::|:|:|:|:|.|:|:..|.|||...|.:||:||||::.|:|||:|.| ..|:|.|||.|: ..
Frog   445 GIDDNEIDRYILNEKEAEIKKEMWMKENEDYLREQKEKEARIAKEKELGIYKEQKPRKPSKR-RA 508

  Fly   502 P--SSTAGEAIEKMLQEKKISSKINYEILKTLTDGMGGLTDDSPTTSADTKPSTLEELKHQPVIV 564
            |  :|||||||||||::|||||||||::|:.|                ::|.|:..  ||....:
Frog   509 PIQASTAGEAIEKMLEQKKISSKINYDVLRDL----------------NSKGSSTP--KHDKNDM 555

  Fly   565 EEGPVASK--SRGNRAAYDLPGP---SRKRPKLEVGLPVSKAADVEQ------AETKPAVVVEAD 618
            |||..:::  .|.:.|:..|..|   :.||.:..|....||....||      ..|.|.:|||:.
Frog   556 EEGITSNQLSRRKSAASKILSNPVSNAGKRIRPLVSTQPSKKVAFEQEVRNELESTPPKIVVESG 620

  Fly   619 DL----DEDADDPDVEPEAEPEATLQDMLNTGGDDDEFGYGFD-EEEEY 662
            .:    ::||...:.|.|.|.|..:..:...||:|    ||.| :|::|
Frog   621 PVTYNHEDDAAAAEEEEEEEEEHCVSALQLMGGND----YGCDMDEDDY 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Brf	NP_001163636.1	TF_Zn_Ribbon	5..44	CDD:285471	24/36 (67%)
		SUA7	6..270	CDD:224323	162/263 (62%)
		CYCLIN	108..164	CDD:294043	35/55 (64%)
		CYCLIN	183..268	CDD:238003	62/84 (74%)
		BRF1	441..531	CDD:285040	52/92 (57%)
brf1	NP_001182550.1	SUA7	3..266	CDD:224323	160/260 (62%)
		MRPL52	<294..341	CDD:376123	12/53 (23%)
		BRF1	445..541	CDD:369495	53/112 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	109	1.000	Domainoid score	I6293
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1161
Inparanoid	1	1.050	474	1.000	Inparanoid score	I1458
OMA	1	1.010	-	-		QHG53031
OrthoDB	1	1.010	-	-		D364940at33208
OrthoFinder	1	1.000	-	-		FOG0002717
OrthoInspector	1	1.000	-	-		oto105240
Panther	1	1.100	-	-	LDO	PTHR11618
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1499
SonicParanoid	1	1.000	-	-		X2091
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110