DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mur89F and CG4835

DIOPT Version :9

Sequence 1:	NP_001262662.1	Gene:	Mur89F / 42080	FlyBaseID:	FBgn0038492	Length:	2159	Species:	Drosophila melanogaster
Sequence 2:	NP_647965.3	Gene:	CG4835 / 38619	FlyBaseID:	FBgn0035607	Length:	1224	Species:	Drosophila melanogaster

Alignment Length:	983	Identity:	274/983 - (27%)
Similarity:	408/983 - (41%)	Gaps:	223/983 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   981 SSNQSSSSNQSSSNQSSSNQSSSSNQTSSSTTQKPFKPAE-----------KCESEETFLADNEN 1034
            |...:.|...:.|..::.....|:.:..||||::.....:           |.|.:.|..|...|
  Fly   343 SVTTTPSITTTPSTPTTLPSDGSTTEIHSSTTEEIVTTTDGLPSDVDPNDCKDEKDGTIFAYIGN 407

  Fly  1035 CSKFYRCVDNGKGGFTKVSF-TCPPNTLWDPEANSCNHPDQI------QTKPLKCKKVVSQGGSS 1092
            ||::..|.||      :|.. .||||||::|:...|:.||.:      .|.|:......:....:
  Fly   408 CSEYLICKDN------QVQMGHCPPNTLFNPDLLVCDEPDDVVCLGDRTTTPIPTTIPTTTTEKT 466

  Fly  1093 SNSTSNSSSSSNNSGSSSNSGSSSSSSSSNSGSSSN----TGSSSNSGASSSGGSSNQGSSSNSG 1153
            :.:|:.::.::.........|....:|.|.....|.    .|....:.|....||....|:...|
  Fly   467 TPTTTTTTVATTLGPDQLCDGQELGASFSYPDDCSKYYLCLGGGQWTLAPCIYGSYFDPSTGQCG 531

  Fly  1154 ---SSSGSNSSGNQSTSSSTSSSSSSSNNNNQGSSSSSSSSSSSTSSKPNPSETC--KVNGQFIG 1213
               :......|...:|:::|::.::::..|....|:::::..::|:..|. :..|  :...:.|.
  Fly   532 PDVAPDACKPSQVTTTTTTTTTETTTTERNTTPKSTATTTERTTTTVAPK-TGICGGRNENENIA 595

  Fly  1214 DRSDCAKFYRCVDNDRGGFNMVP--FSCGPGTVWDAQMQACNHAWAVKECGGIAPPTTSTPTTSR 1276
            ..::|.|:..||       :.:|  |.|..||.:.::::.|...|...:|.|....||..|..:|
  Fly   596 YPNNCTKYIVCV-------SPIPIAFFCPDGTFFSSKLEKCIDDWDESDCEGDQSTTTLEPGYTR 653

  Fly  1277 PTTASTSRPSDQTSTSRPTGP-PTTAR-----------------------PVTAR-----PT--- 1309
            |    ...|:..|::||.|.| |...:                       |:|.:     |:
  Fly   654 P----PPEPTMCTNSSRDTFPYPDNCQWFIRCVDDYIYMMDVCNCGEYYDPITEKCGADVPSDAC 714

  Fly  1310 ----TSSPTTASSSQTTSPVTQAPNTDGKC---RSEGFMADPNNCSKFYRCVRNNKGGFTSIPFQ 1367
                ||:.:|.|...||:.||:.|...|.|   .....:|.||:|||:.:|.|.     .::.|:
  Fly   715 RWDYTSTTSTTSEPTTTTAVTRPPPQKGPCDDVEDGALVAYPNDCSKYIQCDRP-----IAVAFE 774

  Fly  1368 CGAGTVWDQDLQTC-NHNFNNCSTGT------ESTTPK------PPCEPATNGTTATSTSSTTTP 1419
            |..|..:..:|..| :.:..|||..|      .:|||:      .|.||:|..:|.:||.|||.|
  Fly   775 CEKGDEFSVELGKCVDASLANCSITTTAKPSESTTTPRDGEGSTTPSEPSTGSSTESSTESTTEP 839

  Fly  1420 PPTTTDLPPTSTTGLPPTTTTELPPTTTTDLPPTTTTRLPPTTTTSLPPTTTTGLPPTTTTGAQP 1484
               :|:    |||    .:|||....:||:                    ::||....||    .
  Fly   840 ---STE----STT----ESTTESTTESTTE--------------------SSTGQSTETT----E 869

  Fly  1485 TTTTLSSET--ETSTVTTSPESTTQPPST------TTMKPLPAGTECTG---EGYMADPEDCRKY 1538
            ::|.||::|  ..||::|.|.|||..|.|      ||.|  ||...|.|   :..:..|.:|.||
  Fly   870 SSTVLSTDTSESPSTISTPPSSTTMEPGTTNPEASTTEK--PADGICEGKTDDSLVPYPRNCSKY 932

  Fly  1539 YRC---INAGASYRKYNFTCPKGTGWNEEVQTCDYVENIPRCS-KLPAEPITTTPSEESKDP--- 1596
            .:|   |..|       :.||.|..::....||...| :..|| ||....:||..:|.|..|
  Fly   933 IKCQYPIPVG-------YDCPDGLEFSPTELTCMDPE-LAGCSTKLTTPGLTTLSTEASSTPVTT 989

  Fly  1597 GSTTPQ------STDEPTTVTKPITKPTEEPSTEKPQKPTTQYPEKPTTTEEPEKPQKPTTTEYP 1655
            .||||:      ||...||.|:..|..|....:..||..||:.....|||.|        :|...
  Fly   990 VSTTPEATTTEMSTTPKTTTTESTTISTTTTDSTTPQTTTTESTTSKTTTTE--------STIIS 1046

  Fly  1656 QKPTTTEEPTPEKPQKPTTTEYPQKPTTTEEPTPEKPQKPTTTEYPQKPTTEEPTTTSIPGYNPT 1720
            ..|||||..||    |.||||....||||.|.|       |.|..||..|||..|.::    .|.
  Fly  1047 TTPTTTEPTTP----KTTTTESTTIPTTTTEST-------TATTTPQTTTTESTTIST----TPK 1096

  Fly  1721 TTSVPGYNPTTTPIPVETTT-STPGYKPTTTGEPITTTTLPSTTTDAIQEPTTSKKPEPTTTTES 1784
            ||:......:|||...|:|| ||   .|||| ||.|.:|.|.|||           .|.||.|.:
  Fly  1097 TTTTESTTVSTTPTTTESTTIST---TPTTT-EPTTVSTTPKTTT-----------TESTTVTTT 1146

  Fly  1785 PESSTPEGSVTTLQPEPQPNYNCSSE--GFFPDPEDCSRYYRCVDAAKNGKYQV-YAFKCGKGTV 1846
            .||:|...:.|||.|. .||..|...  ...|.|.||.||..|       .|.: ||..|.:||:
  Fly  1147 TESTTTVSTPTTLDPY-TPNICCGQALGTLLPYPNDCGRYVVC-------DYPIPYAVDCDEGTI 1203

  Fly  1847 WDTSTETC 1854
            :|.:...|
  Fly  1204 FDDNLLQC 1211

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mur89F	NP_001262662.1	CBM_14	57..106	CDD:279884
		CBM_14	200..250	CDD:279884
		CBM_14	484..536	CDD:279884
		CBM_14	745..798	CDD:279884
		CBM_14	1025..1074	CDD:279884	18/49 (37%)
		CBM_14	1206..1261	CDD:279884	12/56 (21%)
		CBM_14	1336..1388	CDD:279884	13/52 (25%)
		CBM_14	1523..1577	CDD:279884	15/59 (25%)
		VAD1-2	<1599..>1656	CDD:291956	19/62 (31%)
		CBM_14	1809..1861	CDD:279884	15/49 (31%)
CG4835	NP_647965.3	CBM_14	51..103	CDD:279884
		CBM_14	185..237	CDD:279884
		CBM_14	273..322	CDD:279884
		CBM_14	393..444	CDD:279884	21/56 (38%)
		CBM_14	485..539	CDD:279884	10/53 (19%)
		CBM_14	585..638	CDD:279884	13/59 (22%)
		CBM_14	661..714	CDD:279884	9/52 (17%)
		CBM_14	744..796	CDD:279884	14/56 (25%)
		CBM_14	914..962	CDD:279884	14/54 (26%)
		CBM_14	1175..1212	CDD:279884	15/44 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23301
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100