Protein Alignment MEF2C and mbx2

DIOPT Version :10

• Sequence 1: XP_047273173.1
• Gene: MEF2C / 4208
• HGNCID: 6996
• Length: 511
• Species: Homo sapiens
• Sequence 2: NP_596507.1
• Gene: mbx2 / 2540350
• PomBaseID: SPBC317.01
• Length: 372
• Species: Schizosaccharomyces pombe
• Alignment Length: 456
• Identity: 120/456 - (26%)
• Similarity: 161/456 - (35%)
• Gaps: 138/456 - (30%)

Human     1 MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKV 65
            ||||||.|..|.|:|:|.|||.|||.||.||||||:||.|||:|:.:.:...:|..:.|:|..:.
pombe     1 MGRKKISIAPITDDRSRSVTFVKRKQGLYKKAYELAVLADCEVAVTVIDRKGRLHVFCSSDYQRT 65

Human    66 LLK------YTEYNEPH-------ESRTNSDIVET-----LRKKGLNGCDSPDPDADDSVGHSP- 111
            |.:      |...|..|       ||.|.|....|     |..|.|...|.|..|:....|.||
pombe    66 LQQLNTLSIYELKNRSHFSSSPVEESSTVSPETTTGSFTPLNNKHLKSQDQPLSDSQLDTGDSPA 130

Human   112 ESEDKYRKINEDIDLMISRQRLCALNKKENKGCESPDPDSSYALTPRTEEKYKKINEEFDNMIKS 176
            .||...:..|..:      |..|           .|:|.||                   |.::|
pombe   131 TSETTVQDYNPQV------QSYC-----------RPEPLSS-------------------NHVRS 159

Human   177 HKIPAVPPPNFEMPVSIPVSSHNSLVYSNPVSSLGNPNLLPLAHPSLQRNSMSPGVT-----HRP 236
              .|..||.....|       |....:..|.....|.|..|   |...::.:|||.|     |.|
pombe   160 --CPPFPPTQHHHP-------HTRPPHHPPHPHFHNNNYPP---PYCFQSPVSPGATVPLQHHSP 212

Human   237 -PSAGNTGGLMGGDLTSGAGTSAGNGYGNPR--------------NSPGLLVSPGNLNKNMQAKS 286
             ||                    .||:...|              .||.|...|..|..::
pombe   213 YPS--------------------DNGFPGHRRQTHFAPYYYPQRATSPSLKQVPTYLGTHV---- 253

Human   287 PPPMNLGMNNRKPDLRVLIPPGSKNTMPSVNQRINNSQSAQSLATP--VVSVATPTLPGQGMGGY 349
                 |..:....|.:||:||.|..:.|  ||....:.|..:.|.|  :.....|.|.
pombe   254 -----LQQDQSTYDQKVLMPPASYLSSP--NQYTLKNVSPGNPACPPFLYEHPNPQLT------- 304

Human   350 PSAISTTYG-----TEYSLSSADLSSLSGFNTASALHLGSVTGWQQ------QHLHNMPPSALSQ 403
            |.......|     |.||.||.:.|..:..||....:..|.:...|      |.:.::.|.:||.
pombe   305 PEMFDVKQGSPIPPTAYSGSSCETSQHTIANTPFLAYDRSPSLTNQEAESSFQDVASISPHSLSD 369

Human   404 L 404
            :
pombe   370 V 370

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MEF2C	XP_047273173.1	ARG80	1..291	CDD:227400	89/328 (27%)
		MADS_MEF2_like	2..78	CDD:238165	37/88 (42%)
		HJURP_C	145..201	CDD:463543	11/55 (20%)
mbx2	NP_596507.1	ARG80	1..372	CDD:227400	120/456 (26%)