DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment m-cup and AT4G03440

DIOPT Version :9

Sequence 1:	NP_650607.1	Gene:	m-cup / 42076	FlyBaseID:	FBgn0038488	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_192253.1	Gene:	AT4G03440 / 827920	AraportID:	AT4G03440	Length:	751	Species:	Arabidopsis thaliana

Alignment Length:	674	Identity:	132/674 - (19%)
Similarity:	220/674 - (32%)	Gaps:	242/674 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 ECKRSQEDSLLSRHLR-----HELEKLPRDSRRELVRKQRNGCAPLFIACKRGAVDI---AEYLI 122
            |.:||.:|    :|.|     :.::.|...|.|..:|::.:...|     ....:||   .::|.
plant    19 EAQRSTDD----QHKRRCFPVNVIKNLGTLSSRSFLRRRGDEATP-----PTTTIDIESVPKFLT 74

  Fly   123 TICEANIEQRGHFEVPEDNSFHYV---SPLWAAVVSGKL----SMVKYLVRIGCDINATSDSGST 180
            |:...::     :..|.:    ||   |.:.:|:.:|..    .|..|...:.|..|   :.|.:
plant    75 TLRLLDL-----YNHPGE----YVAMNSEISSAMRAGNKEFLEKMESYETPMSCFKN---NKGDS 127

  Fly   181 PVRSACYMTHVDIVKFLVENGADIKRPNINGGTCLINSVQSVQLCLYLVRKGADINARDIQDKTA 245
            .:..|....|:::||.:|.     |.|:               |.|.|          :.:|:..
plant   128 ILHLAAAFGHLELVKSIVS-----KFPS---------------LLLEL----------NFKDQLP 162

  Fly   246 LHYAIQEHRLDTTKLLI--------------EQGADPY-ARSRYGDDALRTACLKGAHHIFDFLK 295
            ||.|.::..|...|.|:              .:..:|| .:.:.||.||.:|.
plant   163 LHVAARDGHLTVVKALVASVTFCSDRLAEEDRERLNPYILKDKNGDTALHSAL------------ 215

  Fly   296 KQLHYTPARLAEAHELMGSTFLDEHNESRVCILHWRMAHHIRAAYSPYIEKKPQVPLRTAYENAV 360
            |.||   .:..|.||             :...:||                     ||.
plant   216 KDLH---EKTKELHE-------------KTKDMHW---------------------LRR------ 237

  Fly   361 EFSTLEELDNIATDMDAMRTQSLLI--CERVLGLTHKDMLFRLTFRGASYADSLQLQRCIDLWRF 423
              |..:.|.|.:|.:  |.|.:.|:  .:.|..|.:||.:..|
plant   238 --SKSKSLSNESTHL--METAACLVNANQDVSFLANKDEISPL---------------------- 276

  Fly   424 LLEVRVSNWSILHFETCFAAQALVRLMLDLHVQNSSHIRSDARARFVHQDKVLPRFEDVLGVFRT 488
            .|.|...|.|            ||..||:.||.|.             |||.......:.| .::
plant   277 YLAVEAGNVS------------LVNAMLNSHVNNV-------------QDKTFNLATQLKG-RKS 315

  Fly   489 LSESAIVVKHLLLLRPVFRRQ----QENYDRVMRCLA-----HLIYLLINTVHTEAQNKLICQ-- 542
            |..:|:..|:..:|..:..:.    :|..::...||:     .....:...:.|...:...|.
plant   316 LVHAALKAKNTDVLDVILGKYPSLVKERDEKGRTCLSVGASVGFYQGICKLLDTSTLSIFDCDDD 380

  Fly   543 ---AVHEAVVVGNLRSAST-----ADTMLHLCASRLNVI----KSGYITDDNFADKTVFPNADVI 595
               .:|:||..|:......     .|::..|.....|:.    |||        ..|:|....:.
plant   381 GSFPIHKAVEKGHENVVKELLKRFPDSVEQLNKEGQNIFHISAKSG--------KSTLFLMEHIN 437

  Fly   596 KLLIQCGVDVNTKNEAK-------STPLHVACQPYNYDNEIVHLLLKCGGD----IDQPNRADKR 649
            |        |:|||...       :||||:|  ..|:..:.|.:|.|....    :|:.|....|
plant   438 K--------VDTKNHLMEEQDMDGNTPLHLA--TINWRPKTVRMLTKFLSIRKKLLDKHNSVGLR 492

  Fly   650 PYDLIASNPTSTIPLLNFVTLQCL 673
            |.|:...|..|.......:||..|
plant   493 PLDIAEINLQSDYVFRERMTLMVL 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
m-cup	NP_650607.1	ANK repeat	101..175	CDD:293786	15/83 (18%)
		Ank_2	<101..174	CDD:289560	15/82 (18%)
		ANK	147..262	CDD:238125	24/118 (20%)
		Ank_2	149..239	CDD:289560	17/93 (18%)
		ANK repeat	177..208	CDD:293786	7/30 (23%)
		ANK repeat	210..239	CDD:293786	3/28 (11%)
		ANK repeat	241..271	CDD:293786	9/44 (20%)
		Ank_4	244..294	CDD:290365	13/64 (20%)
		ANK	591..>657	CDD:238125	19/76 (25%)
		Ank_2	591..>641	CDD:289560	14/60 (23%)
		ANK repeat	611..641	CDD:293786	9/40 (23%)
AT4G03440	NP_192253.1	ANK	121..292	CDD:238125	54/296 (18%)
		Ank_4	125..179	CDD:290365	17/83 (20%)
		ANK repeat	125..155	CDD:293786	10/49 (20%)
		ANK repeat	157..204	CDD:293786	9/46 (20%)
		Ank_2	163..301	CDD:289560	46/243 (19%)
		ANK	269..401	CDD:238125	31/179 (17%)
		ANK repeat	274..301	CDD:293786	12/73 (16%)
		Ank_2	276..406	CDD:289560	29/177 (16%)
		ANK	342..472	CDD:238125	29/147 (20%)
		ANK repeat	347..378	CDD:293786	3/30 (10%)
		ANK repeat	380..412	CDD:293786	5/31 (16%)
		Ank_5	400..460	CDD:290568	17/75 (23%)
		ANK repeat	414..450	CDD:293786	11/51 (22%)
		PGG	548..655	CDD:290670
		PotE	<557..714	CDD:223605
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	77	1.000	Inparanoid score	I2399
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X100
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.050