DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment m-cup and FEM1C

DIOPT Version :9

Sequence 1:	NP_650607.1	Gene:	m-cup / 42076	FlyBaseID:	FBgn0038488	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_064562.1	Gene:	FEM1C / 56929	HGNCID:	16933	Length:	617	Species:	Homo sapiens

Alignment Length:	657	Identity:	206/657 - (31%)
Similarity:	320/657 - (48%)	Gaps:	99/657 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 LEKLPRDSRRE----LVRKQRNGCAPLFIACKRGAVDIAEYLITICEANIEQRGHFEVPEDNSFH 144
            |.||.....:|    |:.::.||..||.:|.:.|.:|:.|:|:..|.|:||..|.... :..:..
Human    19 LTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNF-DGETIE 82

  Fly   145 YVSPLWAAVVSGKLSMVKYLVRIGCDINATSDSGSTPVRSACYMTHVDIVKFLVENGADIKRPNI 209
            ...|||||..:|.|.:|:.|:..|..:|.|:.:.|||:|:||:..|::|||:|||:.||::..|.
Human    83 GAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNR 147

  Fly   210 NGGTCLINSVQS--VQLCLYLVRKGADINARDIQDKTALHYAIQEHRLDTTKLLIEQGADPYARS 272
            :|.|||:.|...  .::..||:.||||:|.:.::..||||...:...||..|:|:...| ...:.
Human   148 HGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCA-KMEKD 211

  Fly   273 RYGDDALRTACLKGAHHIFDFLKKQLHYTPARLAEAHELMGSTFLDEHNESRVCILHWRMAHHIR 337
            .||...|.:|.:.|..:|.|||......:......|.||:|:||:|:..:....:.:|:.|.::|
Human   212 GYGMTPLLSASVTGHTNIVDFLTHHAQTSKTERINALELLGATFVDKKRDLLGALKYWKKAMNMR 276

  Fly   338 AAYSPYIEKKPQVP--LRTAYENAVEFSTLEELDNIATDMDAMRTQSLLICERVLGLTHKDMLFR 400
            .:....|..|| ||  |..||:.|.|.::.|||:.:..|.|.||.|:|||.||:||.:|.|..:.
Human   277 YSDRTNIISKP-VPQTLIMAYDYAKEVNSAEELEGLIADPDEMRMQALLIRERILGPSHPDTSYY 340

  Fly   401 LTFRGASYADSLQLQRCIDLWRFLLEVRVSNW---------SILHFETCFAAQALVRLMLDLHVQ 456
            :.:|||.||||...:|||:||::.|:::.||.         |:|.|...|:
Human   341 IRYRGAVYADSGNFKRCINLWKYALDMQQSNLDPLSPMTASSLLSFAELFS-------------- 391

  Fly   457 NSSHIRSDARARFVHQDK------VLPRFEDVLGVFRTLSESAIVVKHLLLLRPVFRRQQENYD- 514
                        |:.||:      ....|:|::|         |:.|.:|.:....::.|...|
Human   392 ------------FMLQDRAKGLLGTTVTFDDLMG---------ILCKSVLEIERAIKQTQCPADP 435

  Fly   515 ----RVMRCLAHLIYLLINTVHTEAQNKLICQAVHEAVVVGNLRSASTADTMLHL-------CAS 568
                :.:..:.|||.||.....|..|:....|.::..:.: :.|..:.. :.|||       |..
Human   436 LQLNKALSIILHLICLLEKVPCTLEQDHFKKQTIYRFLKL-HPRGKNNF-SPLHLAVDKNTTCVG 498

  Fly   569 RLNVIKSGYITDDNFADKTVFPNADVIKLLIQCGVDVNTKNEAKSTPLHVACQPYNYDNEIVHLL 633
            |..|.|              ||:..|..:||:||.|||.::...::|||:|.  .|...:|::||
Human   499 RYPVCK--------------FPSLQVTAILIECGADVNVRDSDDNSPLHIAA--LNNHPDIMNLL 547

  Fly   634 LKCGGDIDQPNRADKRPYDL-----IASNPTSTIPLLNFVTLQCLAATAISKHRIPYHNQLHRQL 693
            :|.|...|..|...:...||     ||.|   .|..:|..|||||||..|..|||.|...:..:|
Human   548 IKSGAHFDATNLHKQTASDLLDEKEIAKN---LIQPINHTTLQCLAARVIVNHRIYYKGHIPEKL 609

  Fly   694 EKFVRNH 700
            |.||..|
Human   610 ETFVSLH 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
m-cup	NP_650607.1	ANK repeat	101..175	CDD:293786	25/73 (34%)
		Ank_2	<101..174	CDD:289560	25/72 (35%)
		ANK	147..262	CDD:238125	47/116 (41%)
		Ank_2	149..239	CDD:289560	39/91 (43%)
		ANK repeat	177..208	CDD:293786	15/30 (50%)
		ANK repeat	210..239	CDD:293786	12/30 (40%)
		ANK repeat	241..271	CDD:293786	9/29 (31%)
		Ank_4	244..294	CDD:290365	16/49 (33%)
		ANK	591..>657	CDD:238125	24/70 (34%)
		Ank_2	591..>641	CDD:289560	18/49 (37%)
		ANK repeat	611..641	CDD:293786	10/29 (34%)
FEM1C	NP_064562.1	ANK 1	2..31		4/11 (36%)
		Ank_2	10..110	CDD:403870	29/91 (32%)
		ANK repeat	40..75	CDD:293786	14/34 (41%)
		ANK 2	40..70		12/29 (41%)
		ANK repeat	82..113	CDD:293786	11/30 (37%)
		ANK 3	82..111		10/28 (36%)
		Ank_2	87..178	CDD:403870	39/90 (43%)
		ANK 4	115..144		15/28 (54%)
		ANK repeat	118..146	CDD:293786	14/27 (52%)
		ANK repeat	148..179	CDD:293786	12/30 (40%)
		ANK 5	148..177		11/28 (39%)
		Ank_2	153..236	CDD:403870	27/83 (33%)
		PHA02876	<164..>568	CDD:165207	131/458 (29%)
		ANK 6	181..210		9/29 (31%)
		ANK repeat	181..209	CDD:293786	9/28 (32%)
		ANK 7	213..242		9/28 (32%)
		TPR 1	245..279		10/33 (30%)
		TPR 2	338..371		13/32 (41%)
		ANKYR	<462..599	CDD:223738	47/157 (30%)
		ANK repeat	481..525	CDD:293786	17/58 (29%)
		ANK 8	481..523		16/56 (29%)
		ANK repeat	527..558	CDD:293786	11/32 (34%)
		ANK 9	527..556		10/30 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0508
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D133963at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24173
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920