DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment m-cup and FEM1A

DIOPT Version :9

Sequence 1:	NP_650607.1	Gene:	m-cup / 42076	FlyBaseID:	FBgn0038488	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_061178.1	Gene:	FEM1A / 55527	HGNCID:	16934	Length:	669	Species:	Homo sapiens

Alignment Length:	695	Identity:	207/695 - (29%)
Similarity:	326/695 - (46%)	Gaps:	116/695 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 LLSRHLRHELEKLPRDSRRELVRKQRNGCAPLFIACKRGAVDIAEYLITICEANIEQRG--HFEV 137
            |||...|.||:        ||..:...|..||.||.:.|.:|:.|||:..|.|::|..|  ||
Human    22 LLSGRSREELD--------ELTGEVAGGGTPLLIAARYGHLDVVEYLVDRCGASVEAGGSVHF-- 76

  Fly   138 PEDNSFHYVSPLWAAVVSGKLSMVKYLVRIGCDINATSDSGSTPVRSACYMTHVDIVKFLV-ENG 201
             :..:.....|||||..:|.|.:|:.|:|.|..:|.|:.:.|||:|:||:..|:::|::|| |:.
Human    77 -DGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAACFDGHLEVVRYLVGEHQ 140

  Fly   202 ADIKRPNINGGTCLINSVQS--VQLCLYLVRKGADINARDIQDKTALHYAIQEHRLDTTKLLIEQ 264
            ||::..|.:|.|||:.|...  .::..||:.:||.:|.|..:..||||...:...|:..:||:..
Human   141 ADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKGNTALHDCAESGSLEILQLLLGC 205

  Fly   265 GADPYARSRYGDDALRTACLKGAHHIFDFL------KKQLHYTPAR------------------- 304
            .| ...|..||...|..|.:.|..:|.::|      ::|:....|:
Human   206 KA-RMERDGYGMTPLLAASVTGHTNIVEYLIQEQPGQEQVAGGEAQPGLPQEDPSTSQGCAQPQG 269

  Fly   305 ---------------------------LAEAHELMGSTFLDEHNESRVCILHWRMAHHIRAAYSP 342
                                       ..||.||:|:|::|:..:....:.|||.|..:|.....
Human   270 APCCSSSPEEPLNGESYESCCPTSREAAVEALELLGATYVDKKRDLLGALKHWRRAMELRHQGGE 334

  Fly   343 YIEKKPQVPLRTAYENAVEFSTLEELDNIATDMDAMRTQSLLICERVLGLTHKDMLFRLTFRGAS 407
            |:.|.....|..||:.:.|.:|.|||:.:.||.|.||.|:|||.||:||.:|.|..:.:.:|||.
Human   335 YLPKPEPPQLVLAYDYSREVNTTEELEALITDPDEMRMQALLIRERILGPSHPDTSYYIRYRGAV 399

  Fly   408 YADSLQLQRCIDLWRFLLEVRVSNWSILHFETCFAAQALVRLMLDLHVQNSSHIRSDARARFVHQ 472
            ||||...:|||.||::.|:::.||...|...|..:..:...|.        |::..|..|:....
Human   400 YADSGNFERCIRLWKYALDMQQSNLEPLSPMTASSFLSFAELF--------SYVLQDRAAKGSLG 456

  Fly   473 DKVLPRFEDVLGVFRTLSESAIVVKHLLLLRPVFRRQQENYDRVMRCLAHLIYLLINTVHTEAQN 537
            .::  .|.|::||   |::....|:..|.| |........:.:.:..:.||:|||.....|.:|.
Human   457 TQI--GFADLMGV---LTKGVREVERALQL-PREPGDSAQFTKALAIILHLLYLLEKVECTPSQE 515

  Fly   538 KLICQAVHEAVVVGNLRSASTADTMLHLCASRLNVIKSGYITDDNFADKTV----------FPNA 592
            .|..|.|:.                |..||.|   .|:|:.......||..          ||:.
Human   516 HLKHQTVYR----------------LLKCAPR---GKNGFTPLHMAVDKDTTNVGRYPVGRFPSL 561

  Fly   593 DVIKLLIQCGVDVNTKNEAKSTPLHVACQPYNYDNEIVHLLLKCGGDIDQPNRADKRPYDLIASN 657
            .|:|:|:.||.|.::::...:||||:|.|  |....|::.|::.|..:|..|...|..|:|:...
Human   562 HVVKVLLDCGADPDSRDFDNNTPLHIAAQ--NNCPAIMNALIEAGAHMDATNAFKKTAYELLDEK 624

  Fly   658 --PTSTIPLLNFVTLQCLAATAISKHRIPYHNQLHRQLEKFVRNH 700
              ...|:...|:||||||||.|:.|::|||...:...||.|:..|
Human   625 LLARGTMQPFNYVTLQCLAARALDKNKIPYKGFIPEDLEAFIELH 669

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
m-cup	NP_650607.1	ANK repeat	101..175	CDD:293786	28/75 (37%)
		Ank_2	<101..174	CDD:289560	28/74 (38%)
		ANK	147..262	CDD:238125	44/117 (38%)
		Ank_2	149..239	CDD:289560	36/92 (39%)
		ANK repeat	177..208	CDD:293786	13/31 (42%)
		ANK repeat	210..239	CDD:293786	10/30 (33%)
		ANK repeat	241..271	CDD:293786	8/29 (28%)
		Ank_4	244..294	CDD:290365	15/49 (31%)
		ANK	591..>657	CDD:238125	21/65 (32%)
		Ank_2	591..>641	CDD:289560	16/49 (33%)
		ANK repeat	611..641	CDD:293786	10/29 (34%)
FEM1A	NP_061178.1	ANK 1	2..31		4/8 (50%)
		ANK repeat	40..72	CDD:293786	13/31 (42%)
		ANK 2	40..70		12/29 (41%)
		Ank_4	41..103	CDD:290365	24/64 (38%)
		ANK	43..70	CDD:197603	11/26 (42%)
		ANK	82..203	CDD:238125	44/120 (37%)
		ANK repeat	82..113	CDD:293786	12/30 (40%)
		ANK 3	82..111		11/28 (39%)
		Ank_2	87..179	CDD:289560	36/91 (40%)
		ANK repeat	115..147	CDD:293786	13/31 (42%)
		ANK 4	115..145		13/29 (45%)
		ANK repeat	149..179	CDD:293786	10/29 (34%)
		ANK 5	149..178		9/28 (32%)
		ANK	177..>236	CDD:238125	18/59 (31%)
		ANK repeat	182..211	CDD:293786	8/29 (28%)
		ANK 6	182..211		8/29 (28%)
		Ank_4	183..235	CDD:290365	15/52 (29%)
		ANK 7	214..243		7/28 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	240..278		2/37 (5%)
		TPR 1	298..332		12/33 (36%)
		TPR 2	390..423		13/32 (41%)
		ANK	515..617	CDD:238125	32/122 (26%)
		Ank_5	531..588	CDD:290568	17/59 (29%)
		ANK repeat	534..578	CDD:293786	11/43 (26%)
		ANK 8	534..576		11/41 (27%)
		Ank_5	567..620	CDD:290568	18/54 (33%)
		ANK repeat	580..611	CDD:293786	11/32 (34%)
		ANK 9	580..609		10/30 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0508
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D133963at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24173
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920