DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment m-cup and fem1c

DIOPT Version :9

Sequence 1:	NP_650607.1	Gene:	m-cup / 42076	FlyBaseID:	FBgn0038488	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_937788.2	Gene:	fem1c / 378965	ZFINID:	ZDB-GENE-031008-3	Length:	618	Species:	Danio rerio

Alignment Length:	662	Identity:	205/662 - (30%)
Similarity:	320/662 - (48%)	Gaps:	108/662 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 LEK-LPRDSRRE---LVRKQRNGCAPLFIACKRGAVDIAEYLITICEANIEQRGHF----EVPED 140
            |:| |...|.||   |:.::.||..||.:|.:.|.:::.|:|:..|.|.:|..|..    ||.|.
Zfish    19 LQKLLENKSDREVLKLMAEKTNGATPLLMASRYGHLELVEFLMECCCAPVELGGSVNFDGEVIEG 83

  Fly   141 NSFHYVSPLWAAVVSGKLSMVKYLVRIGCDINATSDSGSTPVRSACYMTHVDIVKFLVENGADIK 205
                 ..|||||..:|.|.:|:.|:..|..:|.|:.:.|||:|:||:..|:|||::|||:.||::
Zfish    84 -----APPLWAASAAGHLKVVQSLLGHGASVNNTTLTNSTPLRAACFDGHLDIVRYLVEHQADLE 143

  Fly   206 RPNINGGTCLINSVQS--VQLCLYLVRKGADINARDIQDKTALHYAIQEHRLDTTKLLIEQGADP 268
            ..|.:|.|||:.|...  .::..:|:.||||:|.|.::..||||...:...|:..|:|::.||.
Zfish   144 VANRHGHTCLMISCYKGHREIAQFLLEKGADVNRRSVKGNTALHDCAESGSLEIMKMLLKFGAS- 207

  Fly   269 YARSRYGDDALRTACLKGAHHIFDFLKKQLHYTPARLAEAHELMGSTFLDEHNESRVCILHWRMA 333
            ..:..||...|.:|.:.|..:|.|||........|....|.||:|:||:|:..:....:.:|:.|
Zfish   208 MEKDGYGMTPLLSASVTGHTNIVDFLTAHPQTGLAERISALELLGATFVDKKRDLLGALQYWKRA 272

  Fly   334 HHIRAAYSPYIEKKPQVPLRTAYENAVEFSTLEELDNIATDMDAMRTQSLLICERVLGLTHKDML 398
            ..:|.:.:..:.::..:....||:.:.|.||.||||.:..|.|.||.|:|||.||:||..|.|..
Zfish   273 MELRHSEADCMRREEPLEPEPAYDCSREVSTAEELDGLIADPDDMRMQALLIRERILGPAHPDTS 337

  Fly   399 FRLTFRGASYADSLQLQRCIDLWRFLLEVRVSNW---------SILHFETCFAAQALVRLMLDLH 454
            :.:.:|||.||||...:|||.||::.|:::.||.         |:|.|...|:
Zfish   338 YYIRYRGAVYADSGNFERCIRLWKYALDMQQSNLEPLSPMTASSLLSFAELFS------------ 390

  Fly   455 VQNSSHIRSDARARFVHQDKVLPRFEDVLGV---FRTLSESAIVVKHLLLLRPVFRRQQENYD-- 514
                          |:.||    |.:.:||.   |:.|.|  |:.:.:|.:....::.:.:.|
Zfish   391 --------------FMLQD----RAKGLLGAGVSFQQLME--ILCRSVLEIERAVKQPRPSPDPD 435

  Fly   515 -----RVMRCLAHLIYLLINTVHTEAQNKLIC---QAVHEAVVVGNLRSASTAD----TMLHL-- 565
                 :::..:.|||.||         .||.|   |..|:...:..........    :.|||
Zfish   436 PAQLSKLLSIILHLICLL---------EKLPCSPEQDQHKKETIYRFLKLQACGRNGFSPLHLAV 491

  Fly   566 -----CASRLNVIKSGYITDDNFADKTVFPNADVIKLLIQCGVDVNTKNEAKSTPLHVACQPYNY 625
                 |..|..|.|              ||:..|..:|::||.|||:::...::|||||..  |.
Zfish   492 DHNTTCVGRYPVCK--------------FPSLQVASVLLECGADVNSRDLDDNSPLHVAAS--NN 540

  Fly   626 DNEIVHLLLKCGGDIDQPNRADKRPYDLI--ASNPTSTIPLLNFVTLQCLAATAISKHRIPYHNQ 688
            ..:|:.||:..|...|..|...:...||:  .....|.|..:|..|||||||.||.:||:.|...
Zfish   541 HPDIMKLLISGGTHFDSTNALQQTACDLLDHTQLAKSLIQPINHTTLQCLAARAIIRHRLVYRGS 605

  Fly   689 LHRQLEKFVRNH 700
            :..:||.||..|
Zfish   606 IPERLEAFVLLH 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
m-cup	NP_650607.1	ANK repeat	101..175	CDD:293786	26/77 (34%)
		Ank_2	<101..174	CDD:289560	26/76 (34%)
		ANK	147..262	CDD:238125	46/116 (40%)
		Ank_2	149..239	CDD:289560	38/91 (42%)
		ANK repeat	177..208	CDD:293786	15/30 (50%)
		ANK repeat	210..239	CDD:293786	11/30 (37%)
		ANK repeat	241..271	CDD:293786	9/29 (31%)
		Ank_4	244..294	CDD:290365	16/49 (33%)
		ANK	591..>657	CDD:238125	21/67 (31%)
		Ank_2	591..>641	CDD:289560	17/49 (35%)
		ANK repeat	611..641	CDD:293786	10/29 (34%)
fem1c	NP_937788.2	Ank_2	<2..62	CDD:289560	15/42 (36%)
		ANK 1	2..31		5/11 (45%)
		Ank_2	<40..112	CDD:289560	26/76 (34%)
		ANK repeat	40..75	CDD:293786	12/34 (35%)
		ANK 2	40..70		10/29 (34%)
		ANK	82..202	CDD:238125	47/124 (38%)
		ANK repeat	82..113	CDD:293786	12/35 (34%)
		ANK 3	82..111		11/33 (33%)
		Ank_2	87..178	CDD:289560	38/90 (42%)
		ANK 4	115..144		15/28 (54%)
		ANK repeat	118..146	CDD:293786	14/27 (52%)
		ANK repeat	148..179	CDD:293786	11/30 (37%)
		ANK 5	148..177		10/28 (36%)
		ANK	176..>236	CDD:238125	20/60 (33%)
		ANK 6	181..210		9/29 (31%)
		ANK repeat	181..209	CDD:293786	9/28 (32%)
		Ank_4	182..233	CDD:290365	16/51 (31%)
		ANK 7	213..243		9/29 (31%)
		TPR 1	245..279		10/33 (30%)
		TPR 2	337..370		13/32 (41%)
		ANK	481..>580	CDD:238125	31/114 (27%)
		ANK repeat	482..526	CDD:293786	16/57 (28%)
		ANK 8	482..524		15/55 (27%)
		Ank_4	483..549	CDD:290365	24/81 (30%)
		ANK 9	528..557		10/30 (33%)
		ANK repeat	528..552	CDD:293786	9/25 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D133963at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24173
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.020