DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment m-cup and Fem1c

DIOPT Version :9

Sequence 1:	NP_650607.1	Gene:	m-cup / 42076	FlyBaseID:	FBgn0038488	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_775599.1	Gene:	Fem1c / 240263	MGIID:	2444737	Length:	617	Species:	Mus musculus

Alignment Length:	660	Identity:	207/660 - (31%)
Similarity:	322/660 - (48%)	Gaps:	98/660 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 LRHELEKLPRDSRRE---LVRKQRNGCAPLFIACKRGAVDIAEYLITICEANIEQRGHFEVPEDN 141
            ||...:.|...|:.|   |:.::.||..||.:|.:.|.:|:.|:|:..|.|:||..|.... :..
Mouse    16 LRLLTKLLASKSKAEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNF-DGE 79

  Fly   142 SFHYVSPLWAAVVSGKLSMVKYLVRIGCDINATSDSGSTPVRSACYMTHVDIVKFLVENGADIKR 206
            :.....|||||..:|.|.:|:.|:..|..:|.|:.:.|||:|:||:..|::|||:|||:.||::.
Mouse    80 TIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEV 144

  Fly   207 PNINGGTCLINSVQS--VQLCLYLVRKGADINARDIQDKTALHYAIQEHRLDTTKLLIEQGADPY 269
            .|.:|.|||:.|...  .::..||:.||||:|.:.::..||||...:...||..|:|:...| ..
Mouse   145 SNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCA-KM 208

  Fly   270 ARSRYGDDALRTACLKGAHHIFDFLKKQLHYTPARLAEAHELMGSTFLDEHNESRVCILHWRMAH 334
            .:..||...|.:|.:.|..:|.|||......:......|.||:|:||:|:..:....:.:|:.|.
Mouse   209 EKDGYGMTPLLSASVTGHTNIVDFLTHHAQTSKTERINALELLGATFVDKKRDLLGALKYWKKAM 273

  Fly   335 HIRAAYSPYIEKKPQVP--LRTAYENAVEFSTLEELDNIATDMDAMRTQSLLICERVLGLTHKDM 397
            ::|.:....|..|| ||  |..||:.|.|.::.|||:.:..|.|.||.|:|||.||:||.:|.|.
Mouse   274 NMRYSDRTNIISKP-VPQTLIMAYDYAKEVNSAEELEGLIADPDEMRMQALLIRERILGPSHPDT 337

  Fly   398 LFRLTFRGASYADSLQLQRCIDLWRFLLEVRVSNW---------SILHFETCFAAQALVRLMLDL 453
            .:.:.:|||.||||...:|||:||::.|:::.||.         |:|.|...|:
Mouse   338 SYYIRYRGAVYADSGNFKRCINLWKYALDMQQSNLDPLSPMTASSLLSFAELFS----------- 391

  Fly   454 HVQNSSHIRSDARARFVHQDK------VLPRFEDVLGVFRTLSESAIVVKHLLLLRPVFRRQQEN 512
                           |:.||:      ....|:|::|         |:.|.:|.:....::.|..
Mouse   392 ---------------FMLQDRAKGLLGTTVTFDDLMG---------ILCKSVLEIERAIKQTQCP 432

  Fly   513 YD-----RVMRCLAHLIYLLINTVHTEAQNKLICQAVHEAVVVGNLRSASTADTMLHL------- 565
            .|     :.:..:.|||.||.....|..|:....|.::..:.: :.|..:.. :.|||
Mouse   433 ADPLQLNKALSIILHLICLLEKVPCTVEQDHFKKQTIYRFLKL-HPRGKNNF-SPLHLAVDKNTT 495

  Fly   566 CASRLNVIKSGYITDDNFADKTVFPNADVIKLLIQCGVDVNTKNEAKSTPLHVACQPYNYDNEIV 630
            |..|..|.|              ||:..|..:||:||.|||.::...::|||:|.  .|...:|:
Mouse   496 CVGRYPVCK--------------FPSLQVTAILIECGADVNVRDSDDNSPLHIAA--LNNHPDIM 544

  Fly   631 HLLLKCGGDIDQPNRADKRPYDL-----IASNPTSTIPLLNFVTLQCLAATAISKHRIPYHNQLH 690
            :||:|.|...|..|...:...||     ||.|   .|..:|..|||||||..|..|||.|...:.
Mouse   545 NLLIKSGAHFDATNLHKQTASDLLDEKEIAKN---LIQPINHTTLQCLAARVIVNHRIYYKGNIP 606

  Fly   691 RQLEKFVRNH 700
            .:||.||..|
Mouse   607 EKLETFVSLH 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
m-cup	NP_650607.1	ANK repeat	101..175	CDD:293786	25/73 (34%)
		Ank_2	<101..174	CDD:289560	25/72 (35%)
		ANK	147..262	CDD:238125	47/116 (41%)
		Ank_2	149..239	CDD:289560	39/91 (43%)
		ANK repeat	177..208	CDD:293786	15/30 (50%)
		ANK repeat	210..239	CDD:293786	12/30 (40%)
		ANK repeat	241..271	CDD:293786	9/29 (31%)
		Ank_4	244..294	CDD:290365	16/49 (33%)
		ANK	591..>657	CDD:238125	24/70 (34%)
		Ank_2	591..>641	CDD:289560	18/49 (37%)
		ANK repeat	611..641	CDD:293786	10/29 (34%)
Fem1c	NP_775599.1	ANK 1	2..31		4/14 (29%)
		Ank_2	10..112	CDD:289560	31/96 (32%)
		ANK repeat	40..75	CDD:293786	14/34 (41%)
		ANK 2	40..70		12/29 (41%)
		ANK	73..202	CDD:238125	47/129 (36%)
		ANK repeat	82..113	CDD:293786	11/30 (37%)
		ANK 3	82..111		10/28 (36%)
		Ank_2	87..178	CDD:289560	39/90 (43%)
		ANK 4	115..144		15/28 (54%)
		ANK repeat	118..146	CDD:293786	14/27 (52%)
		ANK repeat	148..179	CDD:293786	12/30 (40%)
		ANK 5	148..177		11/28 (39%)
		ANK	176..>236	CDD:238125	19/60 (32%)
		ANK 6	181..210		9/29 (31%)
		ANK repeat	181..209	CDD:293786	9/28 (32%)
		Ank_4	182..233	CDD:290365	16/51 (31%)
		ANK 7	213..242		9/28 (32%)
		TPR 1	245..279		10/33 (30%)
		TPR 2	338..371		13/32 (41%)
		ANK	<478..578	CDD:238125	35/119 (29%)
		ANK repeat	481..525	CDD:293786	17/58 (29%)
		ANK 8	481..523		16/56 (29%)
		Ank_4	482..548	CDD:290365	24/82 (29%)
		ANK repeat	527..558	CDD:293786	11/32 (34%)
		ANK 9	527..556		10/30 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0508
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D133963at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24173
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920