DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment m-cup and fem-1

DIOPT Version :9

Sequence 1:	NP_650607.1	Gene:	m-cup / 42076	FlyBaseID:	FBgn0038488	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_500824.1	Gene:	fem-1 / 177335	WormBaseID:	WBGene00001411	Length:	656	Species:	Caenorhabditis elegans

Alignment Length:	682	Identity:	177/682 - (25%)
Similarity:	302/682 - (44%)	Gaps:	127/682 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 RDSRRELV---RKQRNGCAPLFIACKRGAVDIAEYLITICEANIEQRGHFEVPEDNSFHYVSPLW 150
            |:.|:.::   ...::|..||.||.:.|..::.|||:.| .|:...||..|...:| .....|||
Worm    32 RNDRQWIIDCFNSDQDGRYPLVIAARNGHANVVEYLLEI-GADPSVRGVVEFDNEN-IQGTPPLW 94

  Fly   151 AAVVSGKLSMVKYLV-RIGCDINATSDSGSTPVRSACYMTHVDIVKFLVENGADIKRPNINGGTC 214
            ||..:|.:.:||.|: :...|:|..:::.|||:|.|||..|:||||:|:|.|||...||.:|.||
Worm    95 AASAAGHIEIVKLLIEKANADVNQATNTRSTPLRGACYDGHLDIVKYLLEKGADPHIPNRHGHTC 159

  Fly   215 LI-----NSVQSVQLCLYLVRKGADINARDIQDKTALHYAIQEHRLDTTKLLIEQGADPYARSRY 274
            |:     |.|..|:   .|::.|.|:|.:..:..||||.|.:...::..|:|::.|: ...:...
Worm   160 LMIASYRNKVGIVE---ELLKTGIDVNKKTERGNTALHDAAESGNVEVVKILLKHGS-VLMKDIQ 220

  Fly   275 GDDALRTACLKGAHHIFDFLKKQLHYTPARL--AEAHELMGSTFLDEHNESRVCILHW------- 330
            |.|.|..|.|.|...:.:.|..|:   |:.:  .:|.:|:|||.||:..::...:..|
Worm   221 GVDPLMGAALSGFLDVLNVLADQM---PSGIHKRDALKLLGSTLLDKKMDAMSAMNCWKQSMEVP 282

  Fly   331 ------RMAHHIRAAYSPYIEKKPQVPLRTAYENAVEFSTLEELDNIATDMDAMRTQSLLICERV 389
                  |:...:...:.|          :..||...|...:.:::.:..:::|.|.|:|:|.||:
Worm   283 LHADDLRLVREMETFFEP----------QEVYEYQREAQNIAQVELLDGNIEAQRMQALVIRERI 337

  Fly   390 LGLTHKDMLFRLTFRGASYADSLQLQRCIDLWRFLLEVRVSNWSILHFETCFAAQAL---VRLML 451
            ||..|.|:.:.|.||||.|.|..|:.||.|||:..||::..:::.|::.|....|:.   ..:.|
Worm   338 LGGAHTDVHYYLRFRGAVYCDMGQMNRCYDLWKHALELQQKHFAPLYYGTITTLQSFHETFSMSL 402

  Fly   452 DLHVQNSSHIRSDARAR-----FVHQDKVLPRFEDVLGVFRTLSESAIVVKHLLL--------LR 503
            :..| |:.|...:.|.|     :|..           ||...|..:|......||        .|
Worm   403 NDFV-NNHHANRNLRVRSSWVKYVFN-----------GVCLELERAAAWTGAPLLEDTECCGKER 455

  Fly   504 PVFRRQQENYDRVMRCLAHLIYLL----INTVHTEAQNK------------LICQAVHEAVVVGN 552
            .....::..|.:::....||:.:|    :.:.|.:..::            ::|..:|
Worm   456 CQHATEESEYKKLVYVAVHLVNVLERLSLPSAHIDDSDEEKEPKADVRRLMIVCHELH------- 513

  Fly   553 LRSASTADTMLHLCASRLNVIKSGYITDDNFADKTVFPNADVIKLLIQCGVDVNTKNEAKSTPLH 617
                  ...:.|....|        |.|.|.|:..: |.|.|::.|::..:|||..::...||:|
Worm   514 ------IPLLHHTLEER--------IPDSNSAELGL-PKAAVLEQLLELDLDVNATDKNNDTPMH 563

  Fly   618 VACQPYNYDNEIVHLLLKCGGDIDQPNR-------ADKRPYDLIASNPTSTIPLLNFVTLQCLAA 675
            :..:...:...:|..||..|..:...||       ..||...|..:| ...:||...:||..|.|
Worm   564 ILLRAREFRKSLVRALLVRGTWLFARNRHGDVVLNVMKRMKALNHAN-FDDLPLGRHITLAGLVA 627

  Fly   676 TAISKHRIPY-------HNQLHRQLEKFVRNH 700
            .|:   |:.|       ..|:..:|.:|...|
Worm   628 NAM---RVKYPKKFVGVEEQMPLELRRFYLAH 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
m-cup	NP_650607.1	ANK repeat	101..175	CDD:293786	26/74 (35%)
		Ank_2	<101..174	CDD:289560	26/73 (36%)
		ANK	147..262	CDD:238125	47/120 (39%)
		Ank_2	149..239	CDD:289560	40/95 (42%)
		ANK repeat	177..208	CDD:293786	17/30 (57%)
		ANK repeat	210..239	CDD:293786	11/33 (33%)
		ANK repeat	241..271	CDD:293786	8/29 (28%)
		Ank_4	244..294	CDD:290365	14/49 (29%)
		ANK	591..>657	CDD:238125	18/72 (25%)
		Ank_2	591..>641	CDD:289560	13/49 (27%)
		ANK repeat	611..641	CDD:293786	7/29 (24%)
fem-1	NP_500824.1	ANK repeat	7..35	CDD:293786	1/2 (50%)
		Ank_2	12..118	CDD:289560	27/87 (31%)
		ANK repeat	47..86	CDD:293786	14/39 (36%)
		Ank	47..77	CDD:278452	11/30 (37%)
		ANK	83..209	CDD:238125	48/129 (37%)
		ANK repeat	92..120	CDD:293786	11/27 (41%)
		Ank_2	93..185	CDD:289560	40/94 (43%)
		ANK repeat	125..153	CDD:293786	16/27 (59%)
		ANK repeat	155..186	CDD:293786	11/33 (33%)
		ANK repeat	188..212	CDD:293786	7/23 (30%)
		Ank_4	189..240	CDD:290365	14/51 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166563
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28929
OrthoDB	1	1.010	-	-		D133963at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24173
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.960