DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment m-cup and LONRF2

DIOPT Version :9

Sequence 1:NP_650607.1 Gene:m-cup / 42076 FlyBaseID:FBgn0038488 Length:702 Species:Drosophila melanogaster
Sequence 2:NP_940863.3 Gene:LONRF2 / 164832 HGNCID:24788 Length:754 Species:Homo sapiens


Alignment Length:356 Identity:68/356 - (19%)
Similarity:111/356 - (31%) Gaps:134/356 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   381 QSLLICERVLGLTHKDMLF--RLTFRGASYADSLQLQRCIDLWRFLLEVRVSNWSILH--FETCF 441
            :.||.|.|...|.||.:..  .||.          .:||::......:||..| .:|.  .|.||
Human   138 RDLLGCPRCRRLLHKPVTLPCGLTV----------CKRCVEPGPARPQVRRVN-VVLSGLLEKCF 191

  Fly   442 AAQALVRLMLDLHVQNSSHIRSDARA--RFVHQDKVLPRFEDVLGVFRTLSESAIVVKHLLLLRP 504
            .|:..:|           .:...||:  |....:..|.|.:..|       |.|.....|||||.
Human   192 PAECRLR-----------RLAGQARSLQRQQQPEAALLRCDQAL-------ELAPDDNSLLLLRA 238

  Fly   505 VFRRQQENYDRVMR-----C--------------------------LAHLIYLL-----INTVHT 533
            ......:||::.::     |                          |...:|.|     .|:|..
Human   239 ELYLTMKNYEQALQDASAACQNEPLLIKGHQVKAQALSGLGRSKEVLKEFLYCLALNPECNSVKK 303

  Fly   534 EAQNKLICQA-------VHEAVV-------------------------VGNLRSASTADTML-HL 565
            ||| |::|:.       |||.:.                         .|:..::|....|| :.
Human   304 EAQ-KVMCEVLFSATANVHENLTSSIQSRLKAQGHSHMNAQALLEEGDAGSSENSSEKSDMLGNT 367

  Fly   566 CASRLNVIKSGYITDDNFADKTVFPNADVIKLLIQCGVDVNTKNEAKSTPLHVACQPYNYDNEIV 630
            .:|.|..|...:..:|..|.:::.|.|.      ..|:.....::.:..|               
Human   368 NSSVLYFILGLHFEEDKKALESILPTAP------SAGLKRQFPDDVEDAP--------------- 411

  Fly   631 HLLLKCGGDIDQPNRADKRPYDLIASNPTST 661
                    |::.|.:..|:...|..|..:.|
Human   412 --------DLNAPGKIPKKDLSLQRSPNSET 434

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
m-cupNP_650607.1 ANK repeat 101..175 CDD:293786
Ank_2 <101..174 CDD:289560
ANK 147..262 CDD:238125
Ank_2 149..239 CDD:289560
ANK repeat 177..208 CDD:293786
ANK repeat 210..239 CDD:293786
ANK repeat 241..271 CDD:293786
Ank_4 244..294 CDD:290365
ANK 591..>657 CDD:238125 7/65 (11%)
Ank_2 591..>641 CDD:289560 4/49 (8%)
ANK repeat 611..641 CDD:293786 2/29 (7%)
LONRF2NP_940863.3 TPR 1 23..58
TPR_16 27..92 CDD:372602
TPR 2 59..91
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 112..136
RING1-HC_LONFs 143..174 CDD:319427 9/40 (23%)
TPR 3 197..230 9/50 (18%)
TPR repeat 200..225 CDD:276809 6/31 (19%)
TPR repeat 230..260 CDD:276809 8/29 (28%)
TPR 4 231..264 8/32 (25%)
TPR repeat 265..293 CDD:276809 2/27 (7%)
TPR 5 266..298 3/31 (10%)
PEX10 <380..489 CDD:227861 12/84 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 398..439 8/60 (13%)
RING2-HC_LONFs 446..487 CDD:319428
TPR 6 447..483
RING-HC finger (C3HC4-type) 449..486 CDD:319428
LON_substr_bdg 538..738 CDD:366967
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0508
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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