DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment m-cup and Fem1b

DIOPT Version :9

Sequence 1:	NP_650607.1	Gene:	m-cup / 42076	FlyBaseID:	FBgn0038488	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_034323.1	Gene:	Fem1b / 14155	MGIID:	1335087	Length:	627	Species:	Mus musculus

Alignment Length:	637	Identity:	170/637 - (26%)
Similarity:	282/637 - (44%)	Gaps:	85/637 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 QRNG--CAPLFIACKRGAVDIAEYLITICEANIEQRG--HFEVPEDNSFHYV----SPLWAAVVS 155
            |:.|  ..||.||.:.|...:...|:.......:|.|  .|:       .||    :.||.|..:
Mouse    41 QQGGQRSTPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFD-------GYVIDGATALWCAAGA 98

  Fly   156 GKLSMVKYLVRIGCDINATSDSGSTPVRSACYMTHVDIVKFLVENGADIKRPNINGGTCLINSVQ 220
            |...:||.||..|.::|.|:.:.|||:|:||:...:||||:||||.|:|...|....|||:.:..
Mouse    99 GHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAY 163

  Fly   221 S--VQLCLYLVRKGADINARDIQDKTALHYAIQEHRLDTTKLLIEQGADPYARSRYGDDALRTAC 283
            .  ..:..||:.:.||.||:.....||||:|.:...:|..|.||:..| ....:.:|...|:.|.
Mouse   164 KGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRA-AIVVNGHGMTPLKVAA 227

  Fly   284 LKGAHHIFDFLKKQLHYTPARLAEAHELMGSTFLDEHNESRVCILHWRMAHHIRAAY-------S 341
            ......:.:.|............||.||:|::|.::.....:    .:..|::..|.       .
Mouse   228 ESCKADVVELLLSHADCDRRSRIEALELLGASFANDRENYDI----MKTYHYLYLAMLERFQDGD 288

  Fly   342 PYIEKKPQVPLRTAYENAVEFSTLEELDNIATDMDAMRTQSLLICERVLGLTHKDMLFRLTFRGA 406
            ..:||:...|:. ||.|..|....:||:.|..|.||:..:.|::.||:||..:.|:...:.:|||
Mouse   289 NILEKEVLPPIH-AYGNRTECRNPQELEAIRQDRDALHMEGLIVRERILGADNIDVSHPIIYRGA 352

  Fly   407 SYADSLQLQRCIDLWRFLLEVRVSNWSILHFETCFAAQALVRLMLDLHVQNSSHIRSDARA---R 468
            .|||:::.::||.||...|.:|.......|.:....||...:::         |:....:|   .
Mouse   353 VYADNMEFEQCIKLWLHALHLRQKGNRNTHKDLLRFAQVFSQMI---------HLNEAVKAPDIE 408

  Fly   469 FVHQDKVLPRFEDVLGVFRTLSESAIVVKHLLLLRPVFRRQQENYDRVMRCLAHLIYLLINTVHT 533
            .|.:..|| ..|..:...:.:|::.:            ....:||:..:....:|:.:...|..:
Mouse   409 CVLRCSVL-EIEQSMNRVKNISDADV------------HSAMDNYECNLYTFLYLVCISTKTQCS 460

  Fly   534 EAQ----NKLICQAVHEAVVVGNLRSASTAD--TMLHLCASRLNVIKSGYITDD-NFADKTVFPN 591
            |..    ||.|...:|        ....|.:  ::|||      .:.|....|| :..|...|||
Mouse   461 EEDQCRINKQIYNLIH--------LDPRTREGFSLLHL------AVNSNTPVDDFHTNDVCSFPN 511

  Fly   592 ADVIKLLIQCGVDVNTKNEAKSTPLHVACQPYNYD-------NEIVHLLLKCGGDIDQPNRADKR 649
            |.|.|||:.||.:||..:...::.||:..| ||..       :.|:..|::.|...|..|:.:|.
Mouse   512 ALVTKLLLDCGAEVNAVDNEGNSALHIIVQ-YNRPISDFLTLHSIIISLVEAGAHTDMTNKQNKT 575

  Fly   650 PYDLIASNPTSTIPLLNF-VTLQCLAATAISKHRIPYHNQLHRQLEKFVRNH 700
            |.|...:..:..:..... ::|:||||.|:..:.|.|.:|:.|.||:||..|
Mouse   576 PLDKSTTGVSEILLKTQMKMSLKCLAARAVRANDINYQDQIPRTLEEFVGFH 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
m-cup	NP_650607.1	ANK repeat	101..175	CDD:293786	22/81 (27%)
		Ank_2	<101..174	CDD:289560	22/80 (28%)
		ANK	147..262	CDD:238125	44/116 (38%)
		Ank_2	149..239	CDD:289560	37/91 (41%)
		ANK repeat	177..208	CDD:293786	16/30 (53%)
		ANK repeat	210..239	CDD:293786	9/30 (30%)
		ANK repeat	241..271	CDD:293786	10/29 (34%)
		Ank_4	244..294	CDD:290365	13/49 (27%)
		ANK	591..>657	CDD:238125	23/72 (32%)
		Ank_2	591..>641	CDD:289560	18/56 (32%)
		ANK repeat	611..641	CDD:293786	8/36 (22%)
Fem1b	NP_034323.1	Ank_2	11..117	CDD:315466	23/82 (28%)
		ANK 1	45..74		6/28 (21%)
		ANK repeat	48..85	CDD:293786	9/43 (21%)
		ANK	87..207	CDD:238125	44/119 (37%)
		ANK repeat	87..118	CDD:293786	10/30 (33%)
		ANK 2	87..116		9/28 (32%)
		Ank_2	101..>366	CDD:330894	82/270 (30%)
		ANK repeat	120..151	CDD:293786	16/30 (53%)
		ANK 3	120..149		16/28 (57%)
		ANK repeat	153..183	CDD:293786	8/29 (28%)
		ANK 4	153..182		7/28 (25%)
		ANK 5	186..215		10/29 (34%)
		ANK repeat	186..211	CDD:293786	9/24 (38%)
		ANK 6	218..248		4/29 (14%)
		ANK repeat	218..247	CDD:293786	4/28 (14%)
		TPR	344..377		12/32 (38%)
		ANK	478..>577	CDD:238125	31/105 (30%)
		ANK repeat	483..529	CDD:293786	19/51 (37%)
		ANK 7	483..527		18/49 (37%)
		ANK repeat	531..570	CDD:293786	9/39 (23%)
		ANK 8	531..568		8/37 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0508
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810