DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment m-cup and Fem1a

DIOPT Version :9

Sequence 1:	NP_650607.1	Gene:	m-cup / 42076	FlyBaseID:	FBgn0038488	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_034322.3	Gene:	Fem1a / 14154	MGIID:	1335089	Length:	654	Species:	Mus musculus

Alignment Length:	696	Identity:	212/696 - (30%)
Similarity:	330/696 - (47%)	Gaps:	133/696 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 LLSRHLRHELEKLPRDSRRELVRKQRNGCAPLFIACKRGAVDIAEYLITICEANIEQRG--HFEV 137
            ||:...|.|||        ||:.:...|..||.||.:||.:|:.|||:..|.|::|..|  ||
Mouse    22 LLAGRGREELE--------ELLGEVAGGGTPLLIAARRGHLDVVEYLVDHCGASVEASGSVHF-- 76

  Fly   138 PEDNSFHYVSPLWAAVVSGKLSMVKYLVRIGCDINATSDSGSTPVRSACYMTHVDIVKFLV-ENG 201
             :..:.....|||||..:|.|::|:.|:|.|..:|.|:.:.|||:|:||:..|:|:|::|| |:.
Mouse    77 -DGETIEGAPPLWAASAAGHLAVVRSLLRRGASVNRTTRTNSTPLRAACFDGHLDVVRYLVGEHK 140

  Fly   202 ADIKRPNINGGTCLINSVQS--VQLCLYLVRKGADINARDIQDKTALHYAIQEHRLDTTKLLIEQ 264
            ||::..|.:|.|||:.|...  .::..||:.:||.:|.|..:..||||...:...|:..:||:..
Mouse   141 ADLEVANRHGHTCLMISCYKGHREIARYLLERGAQVNRRSAKGNTALHDCAESGSLEILQLLLGC 205

  Fly   265 GADPYARSRYGDDALRTACLKGAHHIFDFL------KKQLH-----------------YTPAR-- 304
            .| ...|..||...|..|.:.|..:|.::|      .:||.                 .||..
Mouse   206 HA-RMERDGYGMTPLLAASVTGHTNIVEYLIQEQPGHEQLSGTELPGEGSSQVAGNHCSTPEEAE 269

  Fly   305 ------------LAEAHELMGSTFLDEHNESRVCILHWRMAHHIRAAYSPYIEKKPQVPLRTAYE 357
                        ..||.||:|:|::|:..:....:.|||.|..:|.....|:.|.....|..||:
Mouse   270 PYESCCPTSREAAVEALELLGATYVDKKRDLLGALKHWRRAMELRHQGGGYLPKPEPQQLVLAYD 334

  Fly   358 NAVEFSTLEELDNIATDMDAMRTQSLLICERVLGLTHKDMLFRLTFRGASYADSLQLQRCIDLWR 422
            .:.|.:|.:||:.:.||.|.||.|:|||.||:||.:|.|..:.:.:|||.||||...:|||.||:
Mouse   335 YSREVTTPQELEALITDPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFERCIRLWK 399

  Fly   423 FLLEVRVSNW---------SILHFETCFAAQALVRLMLDLHVQNSSHIRSDARARFVHQDK---- 474
            :.|:::.:|.         |.|.|...|:                          :|.||:
Mouse   400 YALDMQQNNLEPLSPMTASSFLSFAELFS--------------------------YVLQDRSAKG 438

  Fly   475 ---VLPRFEDVLGVFRTLSESAIVVKHLLLLRPVFRRQQENYDRVMRCLAHLIYLLINTVHTEAQ 536
               :...|.|::||   ||:....|:..|.| |........:.:.:..:.||:|||.....|.:|
Mouse   439 NLGMQLGFADLMGV---LSKGVREVERALQL-PKEPGDSAQFTKAIAIILHLLYLLEKVECTPSQ 499

  Fly   537 NKLICQAVHEAVVVGNLRSASTADTMLHLCASRLNVIKSGYITDDNFADKT----------VFPN 591
            ..|..|.|:.                |..||.|   .|:|:.......||.          |||:
Mouse   500 EHLKHQTVYR----------------LLKCAPR---GKNGFTPLHMAVDKETTNVGRYRVGVFPS 545

  Fly   592 ADVIKLLIQCGVDVNTKNEAKSTPLHVACQPYNYDNEIVHLLLKCGGDIDQPNRADKRPYDLIAS 656
            ..|:|:|:.||.|.::::...:||||:|.|  |....|:..|::.|..:|..|...|..|:|:.|
Mouse   546 LQVVKVLLDCGADPDSRDFDNNTPLHIAAQ--NNCPAIMDALIEAGAHMDATNAFKKTAYELLDS 608

  Fly   657 N--PTSTIPLLNFVTLQCLAATAISKHRIPYHNQLHRQLEKFVRNH 700
            .  ..||:...|:||||||||.|:.::::||...:..:||.|::.|
Mouse   609 KLLAKSTVQPFNYVTLQCLAARALDRNKVPYKGFIPEELEAFIQLH 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
m-cup	NP_650607.1	ANK repeat	101..175	CDD:293786	29/75 (39%)
		Ank_2	<101..174	CDD:289560	29/74 (39%)
		ANK	147..262	CDD:238125	45/117 (38%)
		Ank_2	149..239	CDD:289560	37/92 (40%)
		ANK repeat	177..208	CDD:293786	14/31 (45%)
		ANK repeat	210..239	CDD:293786	10/30 (33%)
		ANK repeat	241..271	CDD:293786	8/29 (28%)
		Ank_4	244..294	CDD:290365	15/49 (31%)
		ANK	591..>657	CDD:238125	21/65 (32%)
		Ank_2	591..>641	CDD:289560	16/49 (33%)
		ANK repeat	611..641	CDD:293786	10/29 (34%)
Fem1a	NP_034322.3	ANK repeat	2..33	CDD:293786	6/18 (33%)
		ANK 1	2..31		3/8 (38%)
		Ank_2	3..112	CDD:289560	37/100 (37%)
		ANK repeat	40..72	CDD:293786	14/31 (45%)
		ANK 2	40..70		13/29 (45%)
		ANK	43..70	CDD:197603	12/26 (46%)
		ANK	82..203	CDD:238125	45/120 (38%)
		ANK repeat	82..113	CDD:293786	12/30 (40%)
		ANK 3	82..111		11/28 (39%)
		Ank_2	87..179	CDD:289560	37/91 (41%)
		ANK repeat	115..147	CDD:293786	14/31 (45%)
		ANK 4	115..145		14/29 (48%)
		ANK repeat	149..179	CDD:293786	10/29 (34%)
		ANK 5	149..178		9/28 (32%)
		ANK	177..>236	CDD:238125	18/59 (31%)
		ANK repeat	182..211	CDD:293786	8/29 (28%)
		ANK 6	182..211		8/29 (28%)
		Ank_4	183..235	CDD:290365	15/52 (29%)
		ANK 7	214..243		7/28 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	242..265		2/22 (9%)
		TPR 1	283..317		12/33 (36%)
		TPR 2	375..408		13/32 (41%)
		ANK	500..602	CDD:238125	33/122 (27%)
		Ank_5	516..573	CDD:290568	18/59 (31%)
		ANK repeat	519..563	CDD:293786	12/43 (28%)
		ANK 8	519..561		12/41 (29%)
		Ank_5	552..605	CDD:290568	18/54 (33%)
		ANK repeat	565..596	CDD:293786	11/32 (34%)
		ANK 9	565..594		10/30 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I12131
eggNOG	1	0.900	-	-		E2759_KOG0508
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D133963at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24173
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920