DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment m-cup and LOC110440003

DIOPT Version :9

Sequence 1:	NP_650607.1	Gene:	m-cup / 42076	FlyBaseID:	FBgn0038488	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	XP_021334017.1	Gene:	LOC110440003 / 110440003	-ID:	-	Length:	289	Species:	Danio rerio

Alignment Length:	280	Identity:	83/280 - (29%)
Similarity:	132/280 - (47%)	Gaps:	40/280 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 LEKLPRDSRRELVRKQRNGCAPLFIACKRGAVDIAEYLITICEANIEQRGHFEVPEDNSFHYVSP 148
            :.|.| :.|..|..::..|..||.||.:.|.:.:..:|:..|.||:|..|.... :..:.....|
Zfish    24 INKSP-EERAALAEERTEGGTPLLIAARYGHLPVVHFLLERCGANVELGGSVNF-DGETIEGAPP 86

  Fly   149 LWAAVVSGKLSMVKYLVRIGCDINATSDSGSTPVRSACYMTHVDIVKFLVENGADIKRPNINGGT 213
            ||||..:|.|.:||.|:..|..:|.|:.:.|||:|:||:..|::||::|||:.||::..|.:|.|
Zfish    87 LWAASAAGHLPVVKALLEHGASVNNTTLTNSTPLRAACFDGHLEIVRYLVEHQADLEVANRHGHT 151

  Fly   214 CLINSVQS--VQLCLYLVRKGADINARDIQDKTALHYAIQEHRLDTTKLL---IEQGADPYARSR 273
            ||:.|...  .::..:|:.||||:|.|.::....|...|    :.|.||:   ::......|.|.
Zfish   152 CLMISCYKGHREIAQFLLEKGADVNRRSVKGGVLLLSLI----IYTCKLITAHLQTHHCTPASSS 212

  Fly   274 YGDDALRTACLKGAH---HIFDFLKKQLHYTPARLA-------EAHELMGSTFLDEHNESRVCI- 327
            ....:|.|..|..||   |         |.|||..:       .||       |..|:.:...|
Zfish   213 PASTSLHTCILITAHLQTH---------HCTPASTSLHTCKHITAH-------LHPHHCTPASIP 261

  Fly   328 --LHWRMAHHIRAAYSPYIE 345
              :|.:.:||...:...|.|
Zfish   262 KCVHAQYSHHTLCSVDNYPE 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
m-cup	NP_650607.1	ANK repeat	101..175	CDD:293786	24/73 (33%)
		Ank_2	<101..174	CDD:289560	24/72 (33%)
		ANK	147..262	CDD:238125	45/119 (38%)
		Ank_2	149..239	CDD:289560	38/91 (42%)
		ANK repeat	177..208	CDD:293786	14/30 (47%)
		ANK repeat	210..239	CDD:293786	11/30 (37%)
		ANK repeat	241..271	CDD:293786	5/32 (16%)
		Ank_4	244..294	CDD:290365	13/55 (24%)
		ANK	591..>657	CDD:238125
		Ank_2	591..>641	CDD:289560
		ANK repeat	611..641	CDD:293786
LOC110440003	XP_021334017.1	Ank_2	<6..68	CDD:330894	13/44 (30%)
		ANK	40..169	CDD:238125	45/129 (35%)
		ANK repeat	40..75	CDD:293786	12/34 (35%)
		ANK repeat	82..113	CDD:293786	12/30 (40%)
		ANK repeat	115..146	CDD:293786	14/30 (47%)
		ANK repeat	148..178	CDD:293786	11/29 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D133963at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010