DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment m-cup and FEM1B

DIOPT Version :9

Sequence 1:	NP_650607.1	Gene:	m-cup / 42076	FlyBaseID:	FBgn0038488	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_056137.1	Gene:	FEM1B / 10116	HGNCID:	3649	Length:	627	Species:	Homo sapiens

Alignment Length:	632	Identity:	174/632 - (27%)
Similarity:	282/632 - (44%)	Gaps:	75/632 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 QRNG--CAPLFIACKRGAVDIAEYLITICEANIEQRG--HFEVPEDNSFHYV----SPLWAAVVS 155
            |:.|  ..||.||.:.|...:...|:.......:|.|  .|:       .||    :.||.|..:
Human    41 QQGGQRSTPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFD-------GYVIDGATALWCAAGA 98

  Fly   156 GKLSMVKYLVRIGCDINATSDSGSTPVRSACYMTHVDIVKFLVENGADIKRPNINGGTCLINSVQ 220
            |...:||.||..|.::|.|:.:.|||:|:||:...:||||:||||.|:|...|....|||:.:..
Human    99 GHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAY 163

  Fly   221 S--VQLCLYLVRKGADINARDIQDKTALHYAIQEHRLDTTKLLIEQGADPYARSRYGDDALRTAC 283
            .  ..:..||:.:.||.||:.....||||:|.:...:|..|.||:..| ....:.:|...|:.|.
Human   164 KGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRA-AIVVNGHGMTPLKVAA 227

  Fly   284 LKGAHHIFDFLKKQLHYTPARLAEAHELMGSTFL-DEHNESRVCILHW-RMAHHIRAAYSPYIEK 346
            ......:.:.|............||.||:|::|. |..|...:...|: .:|...|......|.:
Human   228 ESCKADVVELLLSHADCDRRSRIEALELLGASFANDRENYDIIKTYHYLYLAMLERFQDGDNILE 292

  Fly   347 KPQVPLRTAYENAVEFSTLEELDNIATDMDAMRTQSLLICERVLGLTHKDMLFRLTFRGASYADS 411
            |..:|...||.|..|....:||::|..|.||:..:.|::.||:||..:.|:...:.:|||.|||:
Human   293 KEVLPPIHAYGNRTECRNPQELESIRQDRDALHMEGLIVRERILGADNIDVSHPIIYRGAVYADN 357

  Fly   412 LQLQRCIDLWRFLLEVRVSNWSILHFETCFAAQALVRLMLDLHVQNSSHIRSDARA---RFVHQD 473
            ::.::||.||...|.:|.......|.:....||...:::         |:....:|   ..|.:.
Human   358 MEFEQCIKLWLHALHLRQKGNRNTHKDLLRFAQVFSQMI---------HLNETVKAPDIECVLRC 413

  Fly   474 KVLPRFEDVLGVFRTLSESAIVVKHLLLLRPVFRRQQENYDRVMRCLAHLIYLLINTVHTEAQ-- 536
            .|| ..|..:...:.:|::.:            ....:||:..:....:|:.:...|..:|..
Human   414 SVL-EIEQSMNRVKNISDADV------------HNAMDNYECNLYTFLYLVCISTKTQCSEEDQC 465

  Fly   537 --NKLICQAVHEAVVVGNLRSASTAD--TMLHLCASRLNVIKSGYITDD-NFADKTVFPNADVIK 596
              ||.|...:|        ....|.:  |:|||      .:.|....|| :..|...||||.|.|
Human   466 KINKQIYNLIH--------LDPRTREGFTLLHL------AVNSNTPVDDFHTNDVCSFPNALVTK 516

  Fly   597 LLIQCGVDVNTKNEAKSTPLHVACQPYNYD-------NEIVHLLLKCGGDIDQPNRADKRPYDLI 654
            ||:.||.:||..:...::.||:..| ||..       :.|:..|::.|...|..|:.:|.|.|..
Human   517 LLLDCGAEVNAVDNEGNSALHIIVQ-YNRPISDFLTLHSIIISLVEAGAHTDMTNKQNKTPLDKS 580

  Fly   655 ASNPTSTIPLLNF-VTLQCLAATAISKHRIPYHNQLHRQLEKFVRNH 700
            .:..:..:..... ::|:||||.|:..:.|.|.:|:.|.||:||..|
Human   581 TTGVSEILLKTQMKMSLKCLAARAVRANDINYQDQIPRTLEEFVGFH 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
m-cup	NP_650607.1	ANK repeat	101..175	CDD:293786	22/81 (27%)
		Ank_2	<101..174	CDD:289560	22/80 (28%)
		ANK	147..262	CDD:238125	44/116 (38%)
		Ank_2	149..239	CDD:289560	37/91 (41%)
		ANK repeat	177..208	CDD:293786	16/30 (53%)
		ANK repeat	210..239	CDD:293786	9/30 (30%)
		ANK repeat	241..271	CDD:293786	10/29 (34%)
		Ank_4	244..294	CDD:290365	13/49 (27%)
		ANK	591..>657	CDD:238125	23/72 (32%)
		Ank_2	591..>641	CDD:289560	18/56 (32%)
		ANK repeat	611..641	CDD:293786	8/36 (22%)
FEM1B	NP_056137.1	Ank_2	11..117	CDD:403870	23/82 (28%)
		ANK 1	45..74		6/28 (21%)
		ANK repeat	48..85	CDD:293786	9/43 (21%)
		ANK repeat	87..118	CDD:293786	10/30 (33%)
		ANK 2	87..116		9/28 (32%)
		Ank_2	92..183	CDD:403870	36/90 (40%)
		ANK repeat	120..151	CDD:293786	16/30 (53%)
		ANK 3	120..149		16/28 (57%)
		ANK repeat	153..183	CDD:293786	8/29 (28%)
		ANK 4	153..182		7/28 (25%)
		Ank_2	158..247	CDD:403870	21/89 (24%)
		ANK 5	186..215		10/29 (34%)
		ANK repeat	186..211	CDD:293786	9/24 (38%)
		ANK 6	218..248		4/29 (14%)
		ANK repeat	218..247	CDD:293786	4/28 (14%)
		TPR	344..377		12/32 (38%)
		PHA03095	475..>613	CDD:222980	42/152 (28%)
		ANK repeat	483..529	CDD:293786	20/51 (39%)
		ANK 7	483..527		19/49 (39%)
		ANK repeat	531..570	CDD:293786	9/39 (23%)
		ANK 8	531..568		8/37 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0508
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D133963at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820