DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment m-cup and fem1b

DIOPT Version :9

Sequence 1:	NP_650607.1	Gene:	m-cup / 42076	FlyBaseID:	FBgn0038488	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_001238770.2	Gene:	fem1b / 100488880	XenbaseID:	XB-GENE-999856	Length:	629	Species:	Xenopus tropicalis

Alignment Length:	661	Identity:	187/661 - (28%)
Similarity:	293/661 - (44%)	Gaps:	137/661 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 QRNGCAPLFIACKRGAVDIAEYLITICEANIEQRG--HFEVPEDNSFHYV----SPLWAAVVSGK 157
            ||:  .||.||.:.|...:...|:...:.:::|.|  .|:       .|:    :.||.|..:|.
Frog    47 QRS--TPLIIAARNGHSKVVRLLLEHYKVDVQQTGTVRFD-------GYIIDGATALWCAAGAGH 102

  Fly   158 LSMVKYLVRIGCDINATSDSGSTPVRSACYMTHVDIVKFLVENGADIKRPNINGGTCLINSVQS- 221
            ..:||.||..|.::|.|:.:.|||:|:||:...:|||:|||||.|:|...|....|||:.:...
Frog   103 YEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVRFLVENNANISIANKYDNTCLMIAAYKG 167

  Fly   222 -VQLCLYLVRKGADINARDIQDKTALHYAIQEHRLDTTKLLIEQGADPYARSRYGDDALRTAC-- 283
             ..:..||:.:.||.|||.....||||:|.:...||..:.|::..|...... :|...|:.|.
Frog   168 HTDVVRYLLEQHADPNARAHCGATALHFAAEAGHLDIVRELVKWKAAMVVNG-HGMTPLKVAAES 231

  Fly   284 -------LKGAHHIFDFLKKQLHYTPARLAEAHELMGSTFLDEHNESRVCILHWRMAHHIRAAYS 341
                   |..||...|        |.:|: ||.||:|::|.::..       ::.:....:..|.
Frog   232 CKAEVVELLLAHSDCD--------TKSRI-EALELLGASFANDRE-------NYNLTKTYQYLYL 280

  Fly   342 PYIEK---------KPQVPLRTAYENAVEFSTLEELDNIATDMDAMRTQSLLICERVLGLTHKDM 397
            ..:|:         |..:|...||....|..|.:||..|..:.||:..:.|::.||:||..:.|:
Frog   281 AMLERFRDPSNILHKEVLPPIEAYGMRTECRTPQELGAIIHNTDALHMEGLIVRERILGSDNIDV 345

  Fly   398 LFRLTFRGASYADSLQLQRCIDLWRFLLEVRVSNWSILHFETCFAAQALVRLMLDLHVQNSSHIR 462
            ...:.:|||.|||::|.::||.||...|::|                           |..:
Frog   346 SHPIIYRGAVYADNMQFEQCIKLWLHALQLR---------------------------QKGN--- 380

  Fly   463 SDARARFVHQDKVLPRFEDVLGVFRTLSE--SAIVVKHLL------LLRPVFRRQQ--------- 510
                 |..|:|  |.||..|......|:|  .:..|:|:|      :.|.:.|.|.
Frog   381 -----RNTHKD--LLRFAQVFSQMIHLNEPVKSWDVEHVLECSVLEIERGISRVQNPQEPDAHSA 438

  Fly   511 -ENYDRVMRCLAHLIYLLINTVHTEAQ----NKLICQAVHEAVVVGNLRSASTAD--TMLHLCAS 568
             ||::..:....:|:.:...|..:|.:    ||.|.:.||        ....|.|  |:|||
Frog   439 LENHECNLYTFLYLVCISTKTRCSEEEQPRINKQIYRLVH--------LDPRTRDGCTLLHL--- 492

  Fly   569 RLNVIKSGYITDD-NFADKTVFPNADVIKLLIQCGVDVNTKNEAKSTPLHVACQPYNYD------ 626
               .:.||...|| :..|...||:|.|.||||.||.:||..::..::||||..| ||..
Frog   493 ---AVDSGTPVDDFHTNDVCSFPSAPVAKLLIDCGANVNAVDQMGNSPLHVIVQ-YNRPISDFLT 553

  Fly   627 -NEIVHLLLKCGGDIDQPNRADKRPYDLIASNPTSTIPLLNF-VTLQCLAATAISKHRIPYHNQL 689
             :.|:..|::.|...|..|:..|.|.|...:..:..:..... ::|:||||.|:..|.|.|.||:
Frog   554 LHAIIISLVEAGAHPDMTNKEKKTPLDRSTTGVSEILLKTQMKLSLKCLAARAVRLHNIKYQNQI 618

  Fly   690 HRQLEKFVRNH 700
            .|.||:||..|
Frog   619 PRTLEEFVEFH 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
m-cup	NP_650607.1	ANK repeat	101..175	CDD:293786	20/79 (25%)
		Ank_2	<101..174	CDD:289560	20/78 (26%)
		ANK	147..262	CDD:238125	45/116 (39%)
		Ank_2	149..239	CDD:289560	37/91 (41%)
		ANK repeat	177..208	CDD:293786	16/30 (53%)
		ANK repeat	210..239	CDD:293786	9/30 (30%)
		ANK repeat	241..271	CDD:293786	9/29 (31%)
		Ank_4	244..294	CDD:290365	16/58 (28%)
		ANK	591..>657	CDD:238125	25/72 (35%)
		Ank_2	591..>641	CDD:289560	20/56 (36%)
		ANK repeat	611..641	CDD:293786	10/36 (28%)
fem1b	NP_001238770.2	Ank_2	13..119	CDD:403870	22/80 (28%)
		ANK repeat	50..87	CDD:293786	9/43 (21%)
		ANK repeat	89..120	CDD:293786	10/30 (33%)
		Ank_2	94..185	CDD:403870	36/90 (40%)
		ANK repeat	122..153	CDD:293786	16/30 (53%)
		ANK repeat	155..185	CDD:293786	8/29 (28%)
		Ank_2	160..243	CDD:403870	21/83 (25%)
		ANK repeat	188..213	CDD:293786	8/24 (33%)
		Ank_2	380..>589	CDD:423045	63/233 (27%)
		PHA03095	478..>580	CDD:222980	38/116 (33%)
		ANK repeat	485..531	CDD:293786	22/51 (43%)
		ANK repeat	533..572	CDD:293786	11/39 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D133963at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010