DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5265 and ChAT

DIOPT Version :9

Sequence 1:	NP_650605.1	Gene:	CG5265 / 42074	FlyBaseID:	FBgn0038486	Length:	643	Species:	Drosophila melanogaster
Sequence 2:	NP_477004.5	Gene:	ChAT / 42249	FlyBaseID:	FBgn0000303	Length:	721	Species:	Drosophila melanogaster

Alignment Length:	669	Identity:	205/669 - (30%)
Similarity:	326/669 - (48%)	Gaps:	99/669 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 STAKDKPKSDQPNLL-KYHVLPLEEILNRFMITVQPLLTPEEFKKQEKITNEFQRKE--GAKLQK 97
            |||:...:...|:.| |..|..|:|.:..::..::|:.||.:.::.:::..:|...:  ||:|.:
  Fly    74 STAESVDEFGFPDTLPKVPVPALDETMADYIRALEPITTPAQLERTKELIRQFSAPQGIGARLHQ 138

  Fly    98 LLEETGEQEKNWLAHRWLKVAYLQFRSPVTCFSSPGMTFPKQKFESVHEFVDYTSRVIFGLGEFN 162
            .|.:..|.|.||..:.||...|:..|.|:...|:|||.||.::|::||:...:.:|::.|:....
  Fly   139 YLLDKREAEDNWAYYYWLNEMYMDIRIPLPINSNPGMVFPPRRFKTVHDVAHFAARLLDGILSHR 203

  Fly   163 DLVHAKKIPIVKMGKNE----LDNSQFGKVFGTCRIP------------RRFTDDIVYNPCSDYV 211
            :::.:.::|:.:....|    |..:|:.::.|:||.|            .|..|:      ..:|
  Fly   204 EMLDSGELPLERAASREKNQPLCMAQYYRLLGSCRRPGVKQDSQFLPSRERLNDE------DRHV 262

  Fly   212 VVIYRNHFY--QLKIYDKEGKL--------II-----APCLAVQLEEIMAKEKEPGVPYGILTTD 261
            |||.||..|  .|:..|: |||        |:     ||||..:           .||.|:||.:
  Fly   263 VVICRNQMYCVVLQASDR-GKLSESEIASQILYVLSDAPCLPAK-----------PVPVGLLTAE 315

  Fly   262 SRDNWAEAYEHLSNTPRNRVALKTIQNAMFTVSLDECTSPKEG-------------------RDA 307
            .|..||...|.|....||:..|:.|:.|...:.|||   |..|                   ||.
  Fly   316 PRSTWARDREMLQEDERNQRNLELIETAQVVLCLDE---PLAGNFNARGFTGATPTVHRAGDRDE 377

  Fly   308 EELILTLIHGKGSKCNSANRWMDKTIQLVVNPNGHVGFTYEHSPAEGQPIAMMMDYVVKKMKDDP 372
            ..:...:|||.||:.||.|||.|||:||::..:|..|..||||.:||..:..:::.:.||:::.|
  Fly   378 TNMAHEMIHGGGSEYNSGNRWFDKTMQLIICTDGTWGLCYEHSCSEGIAVVQLLEKIYKKIEEHP 442

  Fly   373 SYGECGSENFIPAKKIKFCDVSKCVEQWLIIAQKNVDKLVQDLQMKVLKFDCYGKDFIKKQRLGP 437
            .......::.:|..:.....|...::.....|.|:|||.:.||...|.::..|||.|||..::.|
  Fly   443 DEDNGLPQHHLPPPERLEWHVGPQLQLRFAQASKSVDKCIDDLDFYVYRYQSYGKTFIKSCQVSP 507

  Fly   438 DSFVQMALQLAFFKLHYEPAAQYESAHLRIFDGGRTETIRSCSNESLAFCHAM------------ 490
            |.::|:|||||.:||:....|.||||..|.|..||.:.||:.|.|:|.:..||
  Fly   508 DVYIQLALQLAHYKLYGRLVATYESASTRRFLHGRVDCIRAASTEALEWAKAMCQGEGANVPLES 572

  Fly   491 --DDVSASAQERAS-----KIREAVMC-----HQMYAKLALLGKGVDRHLFGLKLMAVENCLPVP 543
              :|...|.:.:.|     .:||...|     .::..| .:||.|:|..|.||:..::|....:.
  Fly   573 DREDEEESRKVKFSIYSKDHLRELFRCAVARQTEVMVK-NILGNGIDIPLLGLREASIEVTGEMH 636

  Fly   544 EFFSSPGYVKSTHFRMSTSQVATKYDAFMGYGPSVEDGYACCYNPREHDIILAISAWRHCQATDH 608
            |.|....|:.|..|.:||||||...|:||||||....||.|.|||....|:..:||:..|:.|..
  Fly   637 ELFKDESYIISQCFLLSTSQVACSTDSFMGYGPVTPRGYGCSYNPHPEQIVFCVSAFYSCEDTSA 701

  Fly   609 QKIAKALAQSFAEMKDVLE 627
            .:.||:|..|...|:|:|:
  Fly   702 SRYAKSLQDSLDIMRDLLQ 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5265	NP_650605.1	Carn_acyltransf	49..623	CDD:279140	198/650 (30%)
ChAT	NP_477004.5	Carn_acyltransf	88..716	CDD:279140	198/649 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469035
Domainoid	1	1.000	234	1.000	Domainoid score	I397
eggNOG	1	0.900	-	-		E1_KOG3717
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	235	1.000	Inparanoid score	I707
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D15298at7147
OrthoFinder	1	1.000	-	-		FOG0001049
OrthoInspector	1	1.000	-	-		otm24513
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22589
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X630
	10	9.900