DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5265 and Crat

DIOPT Version :9

Sequence 1:	NP_650605.1	Gene:	CG5265 / 42074	FlyBaseID:	FBgn0038486	Length:	643	Species:	Drosophila melanogaster
Sequence 2:	NP_001004085.1	Gene:	Crat / 311849	RGDID:	1303031	Length:	626	Species:	Rattus norvegicus

Alignment Length:	607	Identity:	222/607 - (36%)
Similarity:	360/607 - (59%)	Gaps:	26/607 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 KSDQPNLLKYHVLPLEEILNRFMITVQPLLTPEEFKKQEKITNEFQRKEGA--KLQKLLEETGEQ 105
            |:.|..|.:..|.||::.|:.::..:||:::.||:...:::.:|||...|.  :|||.||...::
  Rat    29 KAHQDALPRLPVPPLQQSLDHYLKALQPIVSEEEWAHTKQLVDEFQTSGGVGERLQKGLERRAKK 93

  Fly   106 EKNWLAHRWLKVAYLQFRSPVTCFSSPGMTFPKQKFESVHEFVDYTSRVIFGLGEFNDLVHAKKI 170
            .:|||:..|||.||||||.||..:||||:..|||.|..:...:.:.:::|.|:.:|..::..:.:
  Rat    94 MENWLSEWWLKTAYLQFRQPVVIYSSPGVLLPKQDFMDLQGQLRFAAKLIEGVLDFKSMIDNETL 158

  Fly   171 PIVKMGKNELDNSQFGKVFGTCRIPRRFTDDIV-----YNPCSDYVVVIYRNHFYQLKIYDKEGK 230
            |:..:|...|..:|:.::..:||:|....|.:|     ..| ..::.|::...|::|.:|..:|.
  Rat   159 PVEFLGGQPLCMNQYYQILSSCRVPGLKQDSVVNFLKSKKP-PTHITVVHNYQFFELDVYHSDGT 222

  Fly   231 LIIAPCLAVQLEEI----MAKEKEPGVPYGILTTDSRDNWAEAYEHLSNTPRNRVALKTIQNAMF 291
            .:.:..:.||||:|    :...||   |.||||::.|::||:||..|.....||.::.:||.::|
  Rat   223 PLTSDQIFVQLEKIWNSSLQSNKE---PVGILTSNHRNSWAKAYSSLIKDKVNRESVNSIQKSIF 284

  Fly   292 TVSLDECTSPKEGRDA--EELILTLIHGKGSKCNSANRWMDKTIQLVVNPNGHVGFTYEHSPAEG 354
            ||.||: ..|:...|.  ..:...::||.|||.||.|||.|||:|.:|..:|..|..|||:.|||
  Rat   285 TVCLDK-QVPRVSDDVYRSHVAGQMLHGGGSKFNSGNRWFDKTLQFIVAEDGSCGMVYEHAAAEG 348

  Fly   355 QPIAMMMDYVVKKMKDDPSYGECGSENFIP---AKKIKFCDVSKCVEQWLIIAQKNVDKLVQDLQ 416
            .||..::|:|::..|..    |......:|   .||::| :::..::..:..|::|:..::|||.
  Rat   349 PPIVALVDHVMEYTKKP----ELVRSPMVPLPMPKKLRF-NITPEIKNDIEKAKQNISIMIQDLD 408

  Fly   417 MKVLKFDCYGKDFIKKQRLGPDSFVQMALQLAFFKLHYEPAAQYESAHLRIFDGGRTETIRSCSN 481
            :.:|.|..:||||.|.|:|.||:|:|:|||||:::::.:..|.||||.||:|..|||:||||.|.
  Rat   409 IMMLVFHHFGKDFPKSQKLSPDAFIQIALQLAYYRIYGQACATYESASLRMFHLGRTDTIRSAST 473

  Fly   482 ESLAFCHAMDDVSASAQERASKIREAVMCHQMYAKLALLGKGVDRHLFGLKLMAVENCLPVPEFF 546
            :||||...|||.....|:|...:|:||..|:.|...|:.|:..||||.||||.|:|:.:.:|:.|
  Rat   474 DSLAFVKGMDDPKVPEQQRVELLRKAVQAHRAYTDRAIRGEAFDRHLLGLKLQAIEDLVSMPDIF 538

  Fly   547 SSPGYVKSTHFRMSTSQVATKYDAFMGYGPSVEDGYACCYNPREHDIILAISAWRHCQATDHQKI 611
            ....|..:.||.:|||||..|.|..|.:||.|.|||..||||.|..|..::||:..|..|:..::
  Rat   539 MDTSYAIAMHFNLSTSQVPAKTDCVMSFGPVVPDGYGICYNPMEAHINFSVSAYNSCAETNAARM 603

  Fly   612 AKALAQSFAEMKDVLETCPASK 633
            |..|.::..:|:.:|:..|.:|
  Rat   604 AHYLEKALLDMRTLLQNHPRAK 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5265	NP_650605.1	Carn_acyltransf	49..623	CDD:279140	216/589 (37%)
Crat	NP_001004085.1	Carn_acyltransf	35..615	CDD:279140	216/589 (37%)
		Coenzyme A binding. /evidence=ECO:0000250\|UniProtKB:P47934	423..430		3/6 (50%)
		Microbody targeting signal. /evidence=ECO:0000255	624..626		1/2 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352999
Domainoid	1	1.000	409	1.000	Domainoid score	I671
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H598
Inparanoid	1	1.050	418	1.000	Inparanoid score	I1748
OMA	1	1.010	-	-		QHG59015
OrthoDB	1	1.010	-	-		D167256at33208
OrthoFinder	1	1.000	-	-		FOG0001049
OrthoInspector	1	1.000	-	-		mtm9104
orthoMCL	1	0.900	-	-		OOG6_102174
Panther	1	1.100	-	-	O	PTHR22589
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X630
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910