Protein Alignment CG5265 and CPT1A

DIOPT Version :10

• Sequence 1: NP_650605.1
• Gene: CG5265 / 42074
• FlyBaseID: FBgn0038486
• Length: 643
• Species: Drosophila melanogaster
• Sequence 2: NP_001867.2
• Gene: CPT1A / 1374
• HGNCID: 2328
• Length: 773
• Species: Homo sapiens
• Alignment Length: 675
• Identity: 185/675 - (27%)
• Similarity: 311/675 - (46%)
• Gaps: 100/675 - (14%)

  Fly     3 FRDNGKV-----LWNFARISALQQTRYTFGKKMPIASYSTAKDKPKSDQPNLLKYHVLPLEEILN 62
            |.::||:     :|       :...:...|:|..:.|:.|          :|.:..|..:::.:|
Human   137 FTEHGKMSRATKIW-------MGMVKIFSGRKPMLYSFQT----------SLPRLPVPAVKDTVN 184

  Fly    63 RFMITVQPLLTPEEFKKQEKITNEFQRKEGAKLQKLLEETGEQEKNWLAHRWLKVAYLQFRSPVT 127
            |::.:|:||:..|:||:...:..:|....|.:||..|:.......|:::..|.:..||:.|.|:.
Human   185 RYLQSVRPLMKEEDFKRMTALAQDFAVGLGPRLQWYLKLKSWWATNYVSDWWEEYIYLRGRGPLM 249

  Fly   128 CFSS----------PGMTFPKQKFESVHEFVDYTSRVIFGLGEFNDLVHAKKIPIVKMGKN-ELD 181
            ..|:          |......:...::|..:.|..::        |....|  ||..:|.. .|.
Human   250 VNSNYYAMDLLYILPTHIQAARAGNAIHAILLYRRKL--------DREEIK--PIRLLGSTIPLC 304

  Fly   182 NSQFGKVFGTCRIPRRFTDDIVYNPCSDYVVVIYRNHFYQLKIYDKEGKLIIAPCLAVQLEEIM- 245
            ::|:.::|.|.|||...||.|.:...|.::||.:|..::::.:| .:|:|:....:..|::.|:
Human   305 SAQWERMFNTSRIPGEETDTIQHMRDSKHIVVYHRGRYFKVWLY-HDGRLLKPREMEQQMQRILD 368

  Fly   246 -AKEKEPG-VPYGILTTDSRDNWAEAYEHLSNTPRNRVALKTIQNAMFTVSLDECTSPKEGRDAE 308
             ..|.:|| .....||...|..||...:......:|:.:|..::.|.|.|:|||   .:||..:|
Human   369 NTSEPQPGEARLAALTAGDRVPWARCRQAYFGRGKNKQSLDAVEKAAFFVTLDE---TEEGYRSE 430

  Fly   309 E-------LILTLIHGKGSKCNSANRWMDKTIQLVVNPNGHVGFTYEHSPAEGQPIAMMMDYVVK 366
            :       ...:|:||   :|  .:||.||:...||..||.:|...|||.|:...:|.:.:||:.
Human   431 DPDTSMDSYAKSLLHG---RC--YDRWFDKSFTFVVFKNGKMGLNAEHSWADAPIVAHLWEYVMS 490

  Fly   367 KMKDDPSYGECG------SENFIPAKKIKFCDVSKCVEQWLIIAQKN-VDKLVQDLQMKVLKFDC 424
            .......|.|.|      :.|.....::::....:|.|  :|....| .:.|..|:......|..
Human   491 IDSLQLGYAEDGHCKGDINPNIPYPTRLQWDIPGECQE--VIETSLNTANLLANDVDFHSFPFVA 553

  Fly   425 YGKDFIKKQRLGPDSFVQMALQLAFFKLHYEPAAQYESAHLRIFDGGRTETIRSCSNESLAFCHA 489
            :||..|||.|..||:|||:|||||.:|...:....||::..|:|..|||||:|||:.||..|..|
Human   554 FGKGIIKKCRTSPDAFVQLALQLAHYKDMGKFCLTYEASMTRLFREGRTETVRSCTTESCDFVRA 618

  Fly   490 MDDVSASAQERASKIREAVMCHQMYAKLALLGKGVDRHLFGL----KLMAVENCLPVPEFFSSPG 550
            |.|.:.:.::|....:.|...||...:||:.|.|:|||||.|    |.:|||:.. :.|..|.|
Human   619 MVDPAQTVEQRLKLFKLASEKHQHMYRLAMTGSGIDRHLFCLYVVSKYLAVESPF-LKEVLSEP- 681

  Fly   551 YVKSTHFRMSTSQVATKYDAFM-------------GYGPSVEDGYACCY-NPREHDIILAISAWR 601
                  :|:||||...:.....             |:||..:|||...| ...|:.|...||:..
Human   682 ------WRLSTSQTPQQQVELFDLENNPEYVSSGGGFGPVADDGYGVSYILVGENLINFHISSKF 740

  Fly   602 HCQATDHQKIAKALAQSFAEMKDVL 626
            .|..||..:..:.|.::   |.|::
Human   741 SCPETDSHRFGRHLKEA---MTDII 762

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5265	NP_650605.1	Carn_acyltransf	54..617	CDD:459926	174/608 (29%)
CPT1A	NP_001867.2	CPT_N	1..47	CDD:465132
		Carn_acyltransf	174..756	CDD:459926	174/610 (29%)