DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5265 and Crat

DIOPT Version :9

Sequence 1:	NP_650605.1	Gene:	CG5265 / 42074	FlyBaseID:	FBgn0038486	Length:	643	Species:	Drosophila melanogaster
Sequence 2:	XP_006497708.1	Gene:	Crat / 12908	MGIID:	109501	Length:	631	Species:	Mus musculus

Alignment Length:	612	Identity:	219/612 - (35%)
Similarity:	360/612 - (58%)	Gaps:	31/612 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 KSDQPNLLKYHVLPLEEILNRFMITVQPLLTPEEFKKQEKITNEFQRKEGA--KLQKLLEETGEQ 105
            |:.|..|.:..|.||::.|:.::..:||:::.||:...:::.:|||...|.  :|||.||...::
Mouse    29 KAHQDALPRLPVPPLQQSLDYYLKALQPIVSEEEWAHTKQLVDEFQTSGGVGERLQKGLERRAKK 93

  Fly   106 EKNWLAHRWLKVAYLQFRSPVTCFSSPGMTFPKQKFESVHEFVDYTSRVIFGLGEFNDLVHAKKI 170
            .:|||:..|||.||||||.||..:||||:..|||.|..:...:.:.:::|.|:.:|..::..:.:
Mouse    94 MENWLSEWWLKTAYLQFRQPVVIYSSPGVILPKQDFVDLQGQLRFAAKLIEGVLDFKSMIDNETL 158

  Fly   171 PIVKMGKNELDNSQFGKVFGTCRIPRRFTDDIV-----YNPCSDYVVVIYRNHFYQLKIYDKEGK 230
            |:..:|...|..:|:.::..:||:|....|.:|     ..| ..::.|::...|::|.:|..:|.
Mouse   159 PVEFLGGQPLCMNQYYQILSSCRVPGPKQDSVVNFLKSKRP-PTHITVVHNYQFFELDVYHSDGT 222

  Fly   231 LIIAPCLAVQLEEI----MAKEKEPGVPYGILTTDSRDNWAEAYEHLSNTPRNRVALKTIQNAMF 291
            .:.:..:.||||:|    :...||   |.||||::.|:.||:||.:|.....||.::.:||.::|
Mouse   223 PLTSDQIFVQLEKIWNSSLQSNKE---PVGILTSNHRNTWAKAYNNLIKDKVNRESVNSIQKSIF 284

  Fly   292 TVSLDECTSPKEGRDA--EELILTLIHGKGSKCNSANRWMDKTIQLVVNPNGHVGFTYEHSPAEG 354
            ||.||: ..|:...|.  ..:...::||.|||.||.|||.|||:|.:|..:|..|..|||:.|||
Mouse   285 TVCLDK-QVPRVSDDVYRNHVAGQMLHGGGSKFNSGNRWFDKTLQFIVAEDGSCGMVYEHAAAEG 348

  Fly   355 QPIAMMMDYVVKKMKDDPSYGECGSENFIP---AKKIKFCDVSKCVEQWLIIAQKNVDKLVQDLQ 416
            .||..::|:|::..|..    |......:|   .||::| :::..::..:..|::|:..::|||.
Mouse   349 PPIVALVDHVMEYTKKP----ELVRSPMVPLPMPKKLRF-NITPEIKNDIEKAKQNLSIMIQDLD 408

  Fly   417 MKVLKFDCYGKDFIKKQRLGPDSFVQMALQLAFFKLHYEPAAQYESAHLRIFDGGRTETIRSCSN 481
            :.:|.|..:||||.|.::|.||:|:|:|||||:::::.:..|.||||.||:|..|||:||||.|.
Mouse   409 IMMLTFHHFGKDFPKSEKLSPDAFIQVALQLAYYRIYGQACATYESASLRMFHLGRTDTIRSASI 473

  Fly   482 ESLAFCHAMDDVSASAQERASKIREAVMCHQMYA-----KLALLGKGVDRHLFGLKLMAVENCLP 541
            :||||...|.|.:...|::...:|:||..|:.|.     ..|:.|:..||||.||||.|:|:.:.
Mouse   474 DSLAFVKGMGDSTVPEQQKVELLRKAVQAHRAYTDRISHPQAIRGEAFDRHLLGLKLQAIEDLVS 538

  Fly   542 VPEFFSSPGYVKSTHFRMSTSQVATKYDAFMGYGPSVEDGYACCYNPREHDIILAISAWRHCQAT 606
            :|:.|....|..:.||.:|||||..|.|..|.:||.|.|||..||||.|..|..::||:..|..|
Mouse   539 MPDIFMDTSYAIAMHFNLSTSQVPAKTDCVMFFGPVVPDGYGICYNPMEAHINFSVSAYNSCAET 603

  Fly   607 DHQKIAKALAQSFAEMKDVLETCPASK 633
            :..::|..|.::..:|:.:|:..|.:|
Mouse   604 NAARMAHYLEKALLDMRTLLQNHPRAK 630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5265	NP_650605.1	Carn_acyltransf	49..623	CDD:279140	213/594 (36%)
Crat	XP_006497708.1	Carn_acyltransf	35..620	CDD:376382	213/594 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849377
Domainoid	1	1.000	398	1.000	Domainoid score	I746
eggNOG	1	0.900	-	-		E1_KOG3717
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H598
Inparanoid	1	1.050	408	1.000	Inparanoid score	I1860
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59015
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001049
OrthoInspector	1	1.000	-	-		otm43021
orthoMCL	1	0.900	-	-		OOG6_102174
Panther	1	1.100	-	-	O	PTHR22589
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X630
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.760