Protein Alignment CG5265 and CHAT

DIOPT Version :9

• Sequence 1: NP_650605.1
• Gene: CG5265 / 42074
• FlyBaseID: FBgn0038486
• Length: 643
• Species: Drosophila melanogaster
• Sequence 2: NP_065574.4
• Gene: CHAT / 1103
• HGNCID: 1912
• Length: 748
• Species: Homo sapiens
• Alignment Length: 632
• Identity: 206/632 - (32%)
• Similarity: 322/632 - (50%)
• Gaps: 40/632 - (6%)

  Fly    38 AKDKPKSDQPNLLKYHVLPLEEILNRFMITVQPLLTPEEFKKQEKITNEFQRKE--GAKLQKLLE 100
            |...|.|::..|.|..|.||::.|..::..::.|::.|:|:|.:.|..:|....  |..||:.|.
Human   120 AAKTPSSEESGLPKLPVPPLQQTLATYLQCMRHLVSEEQFRKSQAIVQQFGAPGGLGETLQQKLL 184

  Fly   101 ETGEQEKNWLAHRWLKVAYLQFRSPVTCFSSPGMTFPKQKFESVHEFVDYTSRVIFGLGEFNDLV 165
            |..|:..||::..||...||..|..:...|||.:.|.:|.|....:.:.:.:.:|.|:..:..|:
Human   185 ERQEKTANWVSEYWLNDMYLNNRLALPVNSSPAVIFARQHFPGTDDQLRFAASLISGVLSYKALL 249

  Fly   166 HAKKIPIVKMGKNELDN-----SQFGKVFGTCRIPRRFTDDIVYN-----PCSDYVVVIYRNHFY 220
            .:..|| ....|.:|..     .|:..:|.:.|:|....|.:|..     |..::|:|...|.|:
Human   250 DSHSIP-TDCAKGQLSGQPLCMKQYYGLFSSYRLPGHTQDTLVAQNSSIMPEPEHVIVACCNQFF 313

  Fly   221 QLKIYD-----KEGKLIIAPCLAVQLEEIM---AKEKEPGVPYGILTTDSRDNWAEAYEHLSNTP 277
            .|.:..     .||.|.      .||.:|:   :.|.|...|.|:||:|.|..||||...|....
Human   314 VLDVVINFRRLSEGDLF------TQLRKIVKMASNEDERLPPIGLLTSDGRSEWAEARTVLVKDS 372

  Fly   278 RNRVALKTIQNAMFTVSLDECTSPKEGRDAEELILTLIHGKGSKCNSANRWMDKTIQLVVNPNGH 342
            .||.:|..|:..:..|.|| .....|..|... .|.|:||.|...|.||||.||::|.||..:|.
Human   373 TNRDSLDMIERCICLVCLD-APGGVELSDTHR-ALQLLHGGGYSKNGANRWYDKSLQFVVGRDGT 435

  Fly   343 VGFTYEHSPAEGQPIAMMMDYVVKKM-KDDPSYGECGSENFIPA-KKIKFCDVSKC---VEQWLI 402
            .|...||||.:|..:....::::|.: :.........|.:.:|| :::::    ||   ::..|.
Human   436 CGVVCEHSPFDGIVLVQCTEHLLKHVTQSSRKLIRADSVSELPAPRRLRW----KCSPEIQGHLA 496

  Fly   403 IAQKNVDKLVQDLQMKVLKFDCYGKDFIKKQRLGPDSFVQMALQLAFFKLHYEPAAQYESAHLRI 467
            .:.:.:.::|::|...|.|||.|||.|||||:..||:|:|:||||||::||......||||.:|.
Human   497 SSAEKLQRIVKNLDFIVYKFDNYGKTFIKKQKCSPDAFIQVALQLAFYRLHRRLVPTYESASIRR 561

  Fly   468 FDGGRTETIRSCSNESLAFCHAMDDVSAS--AQERASKIREAVMCHQMYAKLALLGKGVDRHLFG 530
            |..||.:.|||.:.|:|||..|:.|..|:  |.|:...:::|:.....|..:|:.|..:|.||..
Human   562 FQEGRVDNIRSATPEALAFVRAVTDHKAAVPASEKLLLLKDAIRAQTAYTVMAITGMAIDNHLLA 626

  Fly   531 LKLMAVENCLPVPEFFSSPGYVKSTHFRMSTSQVATKYDAFMGYGPSVEDGYACCYNPREHDIIL 595
            |:.:|...|..:||.|....|:.|..|.:|||||.|..:.|..|||.|.:||..||||:...|:.
Human   627 LRELARAMCKELPEMFMDETYLMSNRFVLSTSQVPTTTEMFCCYGPVVPNGYGACYNPQPETILF 691

  Fly   596 AISAWRHCQATDHQKIAKALAQSFAEMKDVLETCPASKDKPPELKCK 642
            .||::..|:.|...|.|||:.:|..:|:|:....|.::.||...|.|
Human   692 CISSFHSCKETSSSKFAKAVEESLIDMRDLCSLLPPTESKPLATKEK 738

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5265	NP_650605.1	Carn_acyltransf	49..623	CDD:279140	196/600 (33%)
CHAT	NP_065574.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..89
		PHA03247	<27..138	CDD:223021	6/17 (35%)
		Carn_acyltransf	131..719	CDD:395612	196/600 (33%)
		Coenzyme A binding	520..532		7/11 (64%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	727..748		4/12 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3717
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D167256at33208
OrthoFinder	1	1.000	-	-		FOG0001049
OrthoInspector	1	1.000	-	-		mtm8625
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X630
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.820