Protein Alignment CG5255 and F12

DIOPT Version :10

• Sequence 1: NP_650604.1
• Gene: CG5255 / 42073
• FlyBaseID: FBgn0038485
• Length: 273
• Species: Drosophila melanogaster
• Sequence 2: NP_000496.2
• Gene: F12 / 2161
• HGNCID: 3530
• Length: 615
• Species: Homo sapiens
• Alignment Length: 276
• Identity: 83/276 - (30%)
• Similarity: 122/276 - (44%)
• Gaps: 56/276 - (20%)

  Fly    22 PPQYTKN-----------------RIVGGEEAAAGLAPYQISLQGIGSGAHS-CGGAIIDERWII 68
            ||..|:|                 |:|||..|..|..||..:|.    ..|| |.|::|...|::
Human   348 PPSLTRNGPLSCGQRLRKSLSSMTRVVGGLVALRGAHPYIAALY----WGHSFCAGSLIAPCWVL 408

  Fly    69 TAAHCTRGRQATA-FRVLTGTQDLHQNGS---------KYYYPDRIVEHSNYAPRKYRNDIALLH 123
            |||||.:.|.|.. ..|:.|.:  .:|.|         :.|   |:  |..::|..|::|:|||.
Human   409 TAAHCLQDRPAPEDLTVVLGQE--RRNHSCEPCQTLAVRSY---RL--HEAFSPVSYQHDLALLR 466

  Fly   124 LNES-----IVFDNATQPVELDHEALVPGSRLL--LTGWGTLSLGGDVPAR-LQSLEVNYVPFEQ 180
            |.|.     .:.....|||.|...|..|....|  :.|||....|.:..|. ||..:|.::..|:
Human   467 LQEDADGSCALLSPYVQPVCLPSGAARPSETTLCQVAGWGHQFEGAEEYASFLQEAQVPFLSLER 531

  Fly   181 CRAAHDNSTRVDIGHVCT-FNDKGRGACHGDSGGPLVHNGK-------LVALVNWGLPCA-KGYP 236
            |.|...:.:.:..|.:|. |.:.|..||.||||||||...:       |..:::||..|. :..|
Human   532 CSAPDVHGSSILPGMLCAGFLEGGTDACQGDSGGPLVCEDQAAERRLTLQGIISWGSGCGDRNKP 596

  Fly   237 DAHASISYYHDFIRTH 252
            ..:..::||..:||.|
Human   597 GVYTDVAYYLAWIREH 612

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5255	NP_650604.1	Tryp_SPc	29..249	CDD:214473	76/247 (31%)
F12	NP_000496.2	FN2	41..88	CDD:128373
		EGF_CA	96..131	CDD:238011
		FN1	133..173	CDD:238018
		EGF	178..206	CDD:394967
		Kringle	217..295	CDD:395005
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	298..359		4/10 (40%)
		Tryp_SPc	373..612	CDD:238113	77/249 (31%)