Protein Alignment CG5246 and TMPRSS5

DIOPT Version :10

• Sequence 1: NP_650603.1
• Gene: CG5246 / 42072
• FlyBaseID: FBgn0038484
• Length: 272
• Species: Drosophila melanogaster
• Sequence 2: NP_110397.2
• Gene: TMPRSS5 / 80975
• HGNCID: 14908
• Length: 457
• Species: Homo sapiens
• Alignment Length: 273
• Identity: 82/273 - (30%)
• Similarity: 124/273 - (45%)
• Gaps: 42/273 - (15%)

  Fly    14 SQCSAKSVKIHRRHQLNHHLGHVKPETRVIGGVDSPTGFAPYQVSIMNTFGEHVCGGSIIAPQWI 78
            |:|.|:.:                 .:|::||.....|..|:|.|:...| .|.||||::||:|:
Human   207 SECGARPL-----------------ASRIVGGQSVAPGRWPWQASVALGF-RHTCGGSVLAPRWV 253

  Fly    79 LTAAHCM---------EWPIQYLKIVTGTVDYT--RPGAEYLVDGSKIHCSHDKPAYHNDIALIH 132
            :||||||         .|     ::..|.|.::  ||....||:....|..:....:..|:||:.
Human   254 VTAAHCMHSFRLARLSSW-----RVHAGLVSHSAVRPHQGALVERIIPHPLYSAQNHDYDVALLR 313

  Fly   133 TAKPIVYDDLTQPIKLASKGS-LPKVGDKLTLTGWGSTKTWGRYST-QLQKIDLNYIDHDNCQSR 195
            ....:.:.|....:.|.:|.. .|| |.:..::|||.|.....||: .||...:.......|.|.
Human   314 LQTALNFSDTVGAVCLPAKEQHFPK-GSRCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQLCNSS 377

  Fly   196 VRNANWLSEGHVCTFTQEGEG-SCHGDSGGPLV--DANQ-TLVGVVNWGEACA-IGYPDVFGSVA 255
            ...:..|:...:|....:|.. :|.||||||||  |.:. .|||||:||..|| ..:|.|:..||
Human   378 CVYSGALTPRMLCAGYLDGRADACQGDSGGPLVCPDGDTWRLVGVVSWGRGCAEPNHPGVYAKVA 442

  Fly   256 YYHDWIEQMMTDA 268
            .:.|||.....|:
Human   443 EFLDWIHDTAQDS 455

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5246	NP_650603.1	Tryp_SPc	42..263	CDD:238113	77/238 (32%)
TMPRSS5	NP_110397.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21
		SRCR_2	116..213	CDD:464747	3/5 (60%)
		Tryp_SPc	217..448	CDD:214473	76/237 (32%)