Protein Alignment CG5246 and Cela3b

DIOPT Version :10

• Sequence 1: NP_650603.1
• Gene: CG5246 / 42072
• FlyBaseID: FBgn0038484
• Length: 272
• Species: Drosophila melanogaster
• Sequence 2: NP_080695.1
• Gene: Cela3b / 67868
• MGIID: 1915118
• Length: 269
• Species: Mus musculus
• Alignment Length: 1144
• Identity: 191/1144 - (16%)
• Similarity: 353/1144 - (30%)
• Gaps: 450/1144 - (39%)

  Fly    72 WTKLKTCPIQIFIDEINVDVELTNEHKKQAKSNPLGNLGDSSSYGFMNKIIENMSLYISSVEINF 136
            :|::...|:::|                 ..|:||.:...|.....:.:  .|:.:...:.|:..
Mouse    77 FTEIVMSPVRLF-----------------KPSDPLSSAPLSDHQEPLTE--SNIEISTRAHEVET 122

  Fly   137 DSDVFGGSFMLQRLSVE----SRSPGWAQVKD-LRQTRITCSETNRTLMFKQLSWHLLRIEASAK 196
            :||.|....:.:|.|.|    :.:|...:|.. |....::.|:.::.:        |..|:..:.
Mouse   123 ESDPFRNGLIPKRPSSEKVQCNTAPKRHRVSPRLNFCTVSTSDNHKAV--------LDDIQMPSD 179

  Fly   197 TSKNEQRSKINAPLRLITSGGKIRIALKKNVNDGSVIHA-------RIQTILDDILWVATLPQLR 254
            .:.||: ::||.|      ..:.:..|:....|.|...|       |:...:|:.|:..:..:|.
Mouse   180 VASNEE-NQINCP------STQSQAVLQDETRDTSPCKAQTPFHRSRLNLSIDEPLYSTSATRLS 237

  Fly   255 SAISFASYIAKLVKESQKNDVITTSSGNDNPFMKAAGNSATA----------------------- 296
            |.|:..:....::.........:..||..:..:|:..||.|:
Mouse   238 SEINVHTDAKVVLHPLSAKKCESCGSGKRSTLLKSESNSRTSKTCLNKPDPGAPSFSTSSDFDMK 302

  Fly   297 ----------------------DASTISSAYNIFYFDQTSYHLHVKKIDLHL----CDDAHTASD 335
                                  ...|:|::..:..|:..|     |.:|:.:    .:::...:|
Mouse   303 DKETSTAYSRMATRKSPRKKLFSGFTVSASGELANFETRS-----KTLDVEMKESRSENSKECAD 362

  Fly   336 Y------PP---------------------DWDIESGAMQ------------------VTLYQVL 355
            |      ||                     |..|:|...:                  :||....
Mouse   363 YLSGISDPPKNTSLPQKNAKRCREAPQTKKDLQIKSDCDRMNAGEGRSVRNKNLKDDNITLEVKK 427

  Fly   356 IDVYPKAHAQSDRSTWMRYSNTNPI--AAW-----------FRNHL-------SEQFLTLLGNAE 400
            :|   ..:.| ||......|...|:  :.|           .||.:       .||.::.|
Mouse   428 LD---GTYVQ-DRKKTKSVSTAQPLKDSYWPVDTFHSEDVDRRNSVEASEEVRQEQIVSRL---- 484

  Fly   401 GQTTRTRLERCWPQLIGFFVVLRVHDLTIQCVSDMN-TKKDALTN-------LFE---------S 448
                |..| :|.|.|..    :.|::.| ..||..| |:.|:..|       |.|         :
Mouse   485 ----RKNL-KCKPSLSS----INVNNAT-DTVSPQNGTQNDSTINGSLEHVLLKEPHKTIEPPKT 539

  Fly   449 ERHLHS-------------------------------------LPSDQQIVHVEFGAFYHPHSDK 476
            .|||.|                                     |||:|.....:..:.:.|....
Mouse   540 RRHLRSSTDVSQKRNLRIPKRKDYSMSSVVDPAGPRKPSKRKLLPSEQSTAKEQGASHFGPRVVI 604

  Fly   477 LPVPNSAVYFQLGPFT-----ISFDERTMRWCCYVAHALSSAI--EDGNLIPENELDIQPPT--- 531
            .|:       .|.|.|     ....:|..|...:| ...:.||  ||....||.:.:..|..
Mouse   605 KPL-------LLSPKTKHRKPTKNVKRPSRKDGFV-QTKNGAIRGEDDTGSPEKQTEDVPVVSST 661

  Fly   532 ------IKVNLVMPRLVLNLPG-PFTDFNFPRRLVTSMSTLSISSSQIDFKENSRFRILSESTDE 589
                  :|.:...|    .:|. .|.|::.||......||.|.|...:...........|:.|..
Mouse   662 GSGSIHLKRSYSCP----EIPSIEFNDYHLPRCHTHDSSTTSRSRKSLPAPLPIHHHSPSKRTRR 722

  Fly   590 HSDVKNQLINGLNKFHICT-------SPVWIEIDHGPQTKGFPFLHDVSFNGILAIDKDKVNVLV 647
            |:              :|:       :|:.:..:..|.::|.|......::
Mouse   723 HT--------------VCSVEIEREIAPLCLRKEVYPTSRGSPLSPSSPYS-------------- 759

  Fly   648 EPAEDVAVVVDHYQFLQLTRLGDKFTKFLDQLTLDMKHYNTNKPKSDVTV--DFLASIARIRLYI 710
             |:..:.|:...:....|.        ||.:.:...:.:.:|.....::.  .|:||
Mouse   760 -PSTSLTVLASCFLSSPLA--------FLSKSSSQGRSHASNASSGSISAASSFVAS-------- 807

  Fly   711 VLTMGEIASPYDSAAMSNFNHSFMDRLSDIASTKSITNAHSFSNVNEIKVINEQPRRTNKTATPE 775
                   :||           ||...|     |.::|:.|:|:..:.:             .||.
Mouse   808 -------SSP-----------SFSSPL-----TSTLTSCHAFTGQSSV-------------VTPS 836

  Fly   776 EFPEFPRGGIDNDTSEVASI--ATSIEDEAIYDLSEMPSDDPFGIPEYADEAITIDEPAINDRTF 838
              ||.|...:    |.::|:  .:|:|.:.::.:.             .:|||..:|
Mouse   837 --PETPSASV----SSLSSVFSQSSLETDNVHQME-------------CEEAIAEEE-------- 874

  Fly   839 RHTMAKQANLFMVTLEDLKLAGNVVEE------TLKID------GQLKNIQLSEKLGIVRSEIND 891
                  :.:.|     |.||:.::.||      .:|.|      |::.:|::.:|:...::.:..
Mouse   875 ------ERSDF-----DFKLSASISEEKALSDSEIKTDTKGGQRGKVSSIRICKKIPKPQNNLTP 928

  Fly   892 M--------MKKTGS-EPLDLSK---LPPTYAAAFSFLAPANEK-VSHVTVDVNQLKATIDDEII 943
            |        .||..| |.:..:|   .||.......|..|.|.: .|...|...:||..::   .
Mouse   929 MGLPKVIRIKKKDFSLEEIYTNKNFSKPPDGRLETIFEVPLNRRDGSQAVVGPKKLKRFVE---F 990

  Fly   944 AHLGAFAKDDVITENRLRLAVLVHDSCIQIVDKKKKKPL 982
            ..||                          |.:|.||||
Mouse   991 PELG--------------------------VARKPKKPL 1003

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5246	NP_650603.1	Tryp_SPc	42..263	CDD:238113	36/202 (18%)
Cela3b	NP_080695.1	Tryp_SPc	28..265	CDD:238113	37/221 (17%)