Protein Alignment CG5246 and KLK6

DIOPT Version :10

• Sequence 1: NP_650603.1
• Gene: CG5246 / 42072
• FlyBaseID: FBgn0038484
• Length: 272
• Species: Drosophila melanogaster
• Sequence 2: NP_002765.1
• Gene: KLK6 / 5653
• HGNCID: 6367
• Length: 244
• Species: Homo sapiens
• Alignment Length: 269
• Identity: 72/269 - (26%)
• Similarity: 123/269 - (45%)
• Gaps: 36/269 - (13%)

  Fly     1 MKCLVLISVLVILSQCSAKSVKIHRRHQLNHHLGHVKPETRVIGGVDSPTGFAPYQVSIMNTFGE 65
            ||.|:::..|:..:....::..:|                   ||....|.. |||.::. |.|.
Human     1 MKKLMVVLSLIAAAWAEEQNKLVH-------------------GGPCDKTSH-PYQAALY-TSGH 44

  Fly    66 HVCGGSIIAPQWILTAAHCMEWPIQYLKIVTGTVDYTRPGA---EYLVDGSKIHCSHDKPAYHND 127
            .:|||.:|.|.|:||||||.:   ..|::..|..:..:..:   :..|..:.||..:|..::..|
Human    45 LLCGGVLIHPLWVLTAAHCKK---PNLQVFLGKHNLRQRESSQEQSSVVRAVIHPDYDAASHDQD 106

  Fly   128 IALIHTAKPIVYDDLTQPIKLASKGSLPKVGDKLTLTGWGSTKTWGRYSTQLQKIDLNYIDHDNC 192
            |.|:..|:|....:|.||:.|....|....  ...:.|||.|.. |.:...:|...::.:..:.|
Human   107 IMLLRLARPAKLSELIQPLPLERDCSANTT--SCHILGWGKTAD-GDFPDTIQCAYIHLVSREEC 168

  Fly   193 QSRVRNANWLSEGHVCTFTQE-GEGSCHGDSGGPLVDANQTLVGVVNWGE-AC-AIGYPDVFGSV 254
            :...  ...:::..:|...:: |:.||.|||||||| ....|.|:|:||. .| :...|.|:.:|
Human   169 EHAY--PGQITQNMLCAGDEKYGKDSCQGDSGGPLV-CGDHLRGLVSWGNIPCGSKEKPGVYTNV 230

  Fly   255 AYYHDWIEQ 263
            ..|.:||::
Human   231 CRYTNWIQK 239

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5246	NP_650603.1	Tryp_SPc	42..263	CDD:238113	67/226 (30%)
KLK6	NP_002765.1	Tryp_SPc	23..237	CDD:214473	66/243 (27%)