Protein Alignment CG5246 and PLAT

DIOPT Version :10

• Sequence 1: NP_650603.1
• Gene: CG5246 / 42072
• FlyBaseID: FBgn0038484
• Length: 272
• Species: Drosophila melanogaster
• Sequence 2: NP_000921.1
• Gene: PLAT / 5327
• HGNCID: 9051
• Length: 562
• Species: Homo sapiens
• Alignment Length: 270
• Identity: 79/270 - (29%)
• Similarity: 117/270 - (43%)
• Gaps: 56/270 - (20%)

  Fly    37 KPETRVIGGVDSPTGFAPYQVSIMNTFGEH--------VCGGSIIAPQWILTAAHCME--WPIQY 91
            :|:.|:.||:.:.....|:|.:|   |.:|        :|||.:|:..|||:||||.:  :|..:
Human   306 QPQFRIKGGLFADIASHPWQAAI---FAKHRRSPGERFLCGGILISSCWILSAAHCFQERFPPHH 367

  Fly    92 LKIVTGTVDYTRPGAE---YLVDGSKIHCSHDKPAYHNDIALIHTAKPIVYDDLTQPIKLASKGS 153
            |.::.|......||.|   :.|:...:|...|...|.|||||:...        :...:.|.:.|
Human   368 LTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLK--------SDSSRCAQESS 424

  Fly   154 ------LPKVGDKL------TLTGWGSTKTWGR-YSTQLQKIDLNYIDHDNCQS-----RVRNAN 200
                  ||....:|      .|:|:|..:.... ||.:|::..:.......|.|     |....|
Human   425 VVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQHLLNRTVTDN 489

  Fly   201 WLSEGHVCTFTQEG------EGSCHGDSGGPLV---DANQTLVGVVNWGEACA-IGYPDVFGSVA 255
            .|..|.    |:.|      ..:|.||||||||   |...||||:::||..|. ...|.|:..|.
Human   490 MLCAGD----TRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQKDVPGVYTKVT 550

  Fly   256 YYHDWIEQMM 265
            .|.|||...|
Human   551 NYLDWIRDNM 560

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5246	NP_650603.1	Tryp_SPc	42..263	CDD:238113	76/261 (29%)
PLAT	NP_000921.1	FN1	41..83	CDD:214494
		Important for binding to annexin A2	42..52
		EGF	86..117	CDD:394967
		KR	125..209	CDD:238056
		Kringle	215..296	CDD:395005
		Tryp_SPc	313..559	CDD:238113	76/260 (29%)