Protein Alignment CG5246 and KLK1

DIOPT Version :10

• Sequence 1: NP_650603.1
• Gene: CG5246 / 42072
• FlyBaseID: FBgn0038484
• Length: 272
• Species: Drosophila melanogaster
• Sequence 2: NP_002248.1
• Gene: KLK1 / 3816
• HGNCID: 6357
• Length: 262
• Species: Homo sapiens
• Alignment Length: 253
• Identity: 69/253 - (27%)
• Similarity: 115/253 - (45%)
• Gaps: 38/253 - (15%)

  Fly    39 ETRVIGGVDSPTGFAPYQVSIMNTFGEHVCGGSIIAPQWILTAAHCME-----W----------- 87
            ::|::||.:......|:|.::.: |....|||.::..||:||||||:.     |
Human    22 QSRIVGGWECEQHSQPWQAALYH-FSTFQCGGILVHRQWVLTAAHCISDNYQLWLGRHNLFDDEN 85

  Fly    88 PIQYLKIVTGTVDYTRPGAEY-LVDGSKIHCSHDKPAYHNDIALIHTAKPIVYDDLTQPIKLAS- 150
            ..|::.:   :..:..||... |::........|   |.:|:.|:...:|.  |.:|..:|:..
Human    86 TAQFVHV---SESFPHPGFNMSLLENHTRQADED---YSHDLMLLRLTEPA--DTITDAVKVVEL 142

  Fly   151 KGSLPKVGDKLTLTGWGSTKTWG-RYSTQLQKIDLNYIDHDNC-QSRVRNAN--WLSEGHVCTFT 211
            ....|:||.....:||||.:... .:...||.:||..:.:|.| ::.|:...  .|..||:
Human   143 PTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKILPNDECKKAHVQKVTDFMLCVGHL---- 203

  Fly   212 QEGEGSCHGDSGGPLVDANQTLVGVVNWGEA-CAI-GYPDVFGSVAYYHDWIEQMMTD 267
            :.|:.:|.|||||||: .:..|.||.:||.. |.. ..|.|...|..|..|||..:.:
Human   204 EGGKDTCVGDSGGPLM-CDGVLQGVTSWGYVPCGTPNKPSVAVRVLSYVKWIEDTIAE 260

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5246	NP_650603.1	Tryp_SPc	42..263	CDD:238113	67/244 (27%)
KLK1	NP_002248.1	Tryp_SPc	25..257	CDD:238113	68/245 (28%)