DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5246 and OVCH2

DIOPT Version :9

Sequence 1:	NP_650603.1	Gene:	CG5246 / 42072	FlyBaseID:	FBgn0038484	Length:	272	Species:	Drosophila melanogaster
Sequence 2:	XP_016873148.1	Gene:	OVCH2 / 341277	HGNCID:	29970	Length:	569	Species:	Homo sapiens

Alignment Length:	291	Identity:	84/291 - (28%)
Similarity:	131/291 - (45%)	Gaps:	33/291 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LVLISVLVILSQCSAKSVKIHRRHQLNHHLGHVKP------ETRVIGGVDSPTGFAPYQVSIMNT 62
            |:|:..:|...:..:.::.:.:.......|..|:|      .:|::||.....|..|:|||:...
Human    12 LILLLGIVFFERGKSATLSLPKAPSCGQSLVKVQPWNYFNIFSRILGGSQVEKGSYPWQVSLKQR 76

  Fly    63 FGEHVCGGSIIAPQWILTAAHCM--EWPIQYLKIVTGTVD--YTRPGAEYLVDGSKI---HCSHD 120
             .:|:|||||::|||::|||||:  ...:..|.:..|..|  .|.||.:.|...:.|   |.|..
Human    77 -QKHICGGSIVSPQWVITAAHCIANRNIVSTLNVTAGEYDLSQTDPGEQTLTIETVIIHPHFSTK 140

  Fly   121 KPAYHNDIALIHTAKPIVYDDLTQPIKLASKGSLPKVGDKLTLTGWGSTKTWGRYSTQLQKIDLN 185
            ||..: ||||:..|....:.....||.|.......:.|...|..|||.....|..|..||:::|.
Human   141 KPMDY-DIALLKMAGAFQFGHFVGPICLPELREQFEAGFICTTAGWGRLTEGGVLSQVLQEVNLP 204

  Fly   186 YIDHDNCQSRVRNANWLSEG--HVCT-FTQEGEGSCHGDSGGPLVDANQ----TLVGVVNWGEAC 243
            .:..:.|.:.:........|  .:|| |...|..:|.|||||.|:..|:    ||.||.:||..|
Human   205 ILTWEECVAALLTLKRPISGKTFLCTGFPDGGRDACQGDSGGSLMCRNKKGAWTLAGVTSWGLGC 269

  Fly   244 AIGY-----------PDVFGSVAYYHDWIEQ 263
            ..|:           |.:|..::....||.:
Human   270 GRGWRNNVRKSDQGSPGIFTDISKVLPWIHE 300

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5246	NP_650603.1	Tryp_SPc	41..261	CDD:214473	76/244 (31%)
CG5246	NP_650603.1	Tryp_SPc	42..263	CDD:238113	77/245 (31%)
OVCH2	XP_016873148.1	Tryp_SPc	55..298	CDD:214473	76/244 (31%)
		Tryp_SPc	56..301	CDD:238113	77/247 (31%)
		CUB	320..424	CDD:238001
		CUB	435..546	CDD:238001
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910