Protein Alignment CG5246 and Klk14

DIOPT Version :10

• Sequence 1: NP_650603.1
• Gene: CG5246 / 42072
• FlyBaseID: FBgn0038484
• Length: 272
• Species: Drosophila melanogaster
• Sequence 2: NP_777355.1
• Gene: Klk14 / 317653
• MGIID: 2447564
• Length: 250
• Species: Mus musculus
• Alignment Length: 994
• Identity: 184/994 - (18%)
• Similarity: 328/994 - (32%)
• Gaps: 353/994 - (35%)

  Fly    21 KPEQISL-------DVLKGNSKLQFIEINEDVL------TEILELPSWLKIKRAFCTGV----AV 68
            :||.:||       ::...:||    |.:.|..      ||    ||.|.|...:...:    ..
Mouse   113 EPEPLSLPPQLPPRNIFSNDSK----ESHNDPSRGTDRGTE----PSRLSISDTYFQRLQQIDIS 169

  Fly    69 NVPWTKLKTCPIQIFIDEINVDVE------LTNEHKKQAKSNPLGNLGDSSSYGFMNKIIENMSL 127
            |:|....|:.. :.|...:.:|.|      .|..|.|:...|                |.:|::.
Mouse   170 NLPEDHQKSIQ-EYFRASVCLDAEQVQNGNQTLPHFKKLTQN----------------ICKNLNS 217

  Fly   128 YISSVEINFDSDVFGGSFMLQRLSVESRSPGWAQVKDLRQTRITCSETNRTLMFK--QLSWHLLR 190
            .|:....:|::        ||::..:..|||..:::    |::: ::.|.::.|:  ||:..:..
Mouse   218 EIARTLPSFEA--------LQKVLDQPLSPGAGRLR----TQLS-ADANPSVAFRLEQLTKLIQS 269

  Fly   191 IEASAKTSKNE-------QRSKINAPLRLITSGGKIRIA----LKKNVNDGSVIHARIQTILDDI 244
            ||...|.:..|       .|:.:..|:........:.|:    ||.:|..|.|...:.:...:|.
Mouse   270 IEDKTKNAVFEFVGYDGGHRNSLIPPVTFEVKSDSLGISNKMYLKVDVEGGKVYFKKSKDGPEDK 334

  Fly   245 LWVATLPQLRSAISFASYIAKLVKESQKND----VITTSSGNDNPFMKAAGNSATADASTISSAY 305
            .:|            .:.|.:|||..:.::    |:.|..          |.:.:.|
Mouse   335 YFV------------HNKILQLVKSQKMHNRLVLVVETEK----------GKTQSKD-------- 369

  Fly   306 NIFYFDQTSYHLHVKKID-----LHLCDDAHTASDYPPDWDIESGAMQVTLYQVLIDVYPKAHAQ 365
              |.||.|      ||.:     |....:.|:....|.         .:|::.
Mouse   370 --FVFDDT------KKREGFCQLLQQMKNKHSGKPEPD---------MITIFV------------ 405

  Fly   366 SDRSTWMRYSNTNP---IAAWFRNHLSEQFLTLLGNAEGQT---TRTRLERCWPQLIGFFVVLRV 424
               .|| ...|.||   |.:||::           ..:|:|   |..::.
Mouse   406 ---GTW-NMGNANPPQNITSWFQS-----------KGQGKTHDDTANQIP--------------- 440

  Fly   425 HDLTIQCVSDMNTKKDAL----------------TNLFESERHLHSLPSDQQIVHVE---FGAFY 470
            ||:.:     :.|::|.|                ||:...:....:|.|.:.:|..:   ...|.
Mouse   441 HDIYV-----IGTQEDPLGEKEWIETIRGALRDITNISFKQIATQTLWSIRIVVLAKPEHENRFS 500

  Fly   471 HPHSDKLPVPNSAVYFQLGPFTISFDERTMRWCCYVAHALSSAIEDGNLIPENELDIQPPTIKVN 535
            |..||.:...                         :|:||      ||          ...:.|:
Mouse   501 HIFSDSVKTG-------------------------IANAL------GN----------KGAVGVS 524

  Fly   536 LVMPRLVLNLPGPFTDFNFPRRLVTSMSTLSISSSQIDFKENSRFRILSESTDEHSDVKNQLING 600
            .:..|         |.|.|....:||.|...:..:| ::....||..|.:          :.:|.
Mouse   525 FMFNR---------TSFGFVNSHLTSGSEKKLRRNQ-NYVSILRFLNLGD----------KKVNP 569

  Fly   601 LNKFHICTSPVWI-----EID---HGPQTKGFPFLHDVSFNGILA-----IDKDKVNVLVEPAED 652
            .:..|..|...|:     .:|   |..:..... :....:..:||     |:||:..|.:|..|:
Mouse   570 FDITHRFTHLFWLGDLNYRVDLPSHEAENIVMK-IKQQQYKELLAQDQLKIEKDEEKVFLEYVEE 633

  Fly   653 VAVVVDHYQFLQLTRLGDKFTKFLDQLTLDMKHYNTNKPKSDVTVDFLAS----IARIRLYIVLT 713
            .......|:|.:.||                :.|...|.|:..|...|.|    :.| :.|.::.
Mouse   634 EITFAPTYRFERDTR----------------ERYAYTKAKATGTKYNLPSWCDRVLR-KSYPLVH 681

  Fly   714 MGEIASPYD-SAAMSNFNHSFMDRLSDIASTKSITNAHSFSN--VNEIKVINEQPRRTNKTATP- 774
            :  :.:.|. :..:...:||.:....|:..|....:.:..||  ...||::|.......|:.|.
Mouse   682 V--VCNSYGCTNDIMTSDHSPVFATFDVGVTSQFVSKNDLSNDARGAIKILNCVAVLCTKSKTKF 744

  Fly   775 ---------EEFPEFPRGGIDNDTSEVASIATSIEDEAIYDLSEMPSDDPFGIPEY-ADEAITI- 828
                     |:|...|.|  :|...| .||......:.  :|:.:.:|     ||| .|:.|.|
Mouse   745 FIEYHSSCLEKFVRSPDG--ENQEME-GSIKVRFAGQV--ELTPIIAD-----PEYLLDQHILIC 799

  Fly   829 ------DEP------AINDRTFRHTMAKQANLFMVTLEDLKLAGNVVEETLKIDGQLKNIQLSEK 881
                  ||.      |:......:|.      |.:||.      :..|.|..:.|.   |||.:.
Mouse   800 IKSTDSDESYGEGCVALRSAESSYTE------FSITLT------HHGERTGWLTGA---IQLPKS 849

  Fly   882 LGIVRSEINDMMKKTGSEP 900
            .|....::.|.: |.|.:|
Mouse   850 EGKQTEKLYDFI-KVGDDP 867

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5246	NP_650603.1	Tryp_SPc	42..263	CDD:238113	45/249 (18%)
Klk14	NP_777355.1	Tryp_SPc	24..246	CDD:238113	33/169 (20%)