Protein Alignment CG5246 and TMPRSS12

DIOPT Version :10

• Sequence 1: NP_650603.1
• Gene: CG5246 / 42072
• FlyBaseID: FBgn0038484
• Length: 272
• Species: Drosophila melanogaster
• Sequence 2: NP_872365.2
• Gene: TMPRSS12 / 283471
• HGNCID: 28779
• Length: 348
• Species: Homo sapiens
• Alignment Length: 286
• Identity: 83/286 - (29%)
• Similarity: 136/286 - (47%)
• Gaps: 36/286 - (12%)

  Fly    15 QCSAKSVKIHRRHQLNHH--------LGHVKPETRVIGGVDSPTGFAPYQVSIMNTFGE---HVC 68
            |..|...::.||.:...|        |..|...:|:|||.::..|..|:.||:...:|.   |||
Human    43 QAEAVRKRLRRRREGGAHAEDCGTAPLKDVLQGSRIIGGTEAQAGAWPWVVSLQIKYGRVLVHVC 107

  Fly    69 GGSIIAPQWILTAAHCME---WPIQYLKIV-TGTVDYTRPGAEYL-VDGSKIHCSHDKPAYHNDI 128
            ||:::..:|:||||||.:   .|:.:..:: |..:....|..:.: :....||.:....:|.|||
Human   108 GGTLVRERWVLTAAHCTKDASDPLMWTAVIGTNNIHGRYPHTKKIKIKAIIIHPNFILESYVNDI 172

  Fly   129 ALIHTAKPIVYDDLTQPIKLASKGSLP----KVGD---KLTLTGWGSTKTWGRYSTQLQKIDLNY 186
            ||.|..|.:.|:|..|||      .||    ::.|   |..::|||.||..|..:..||..:::|
Human   173 ALFHLKKAVRYNDYIQPI------CLPFDVFQILDGNTKCFISGWGRTKEEGNATNILQDAEVHY 231

  Fly   187 IDHDNCQSRVRNANWLSEGHVCTFTQEGE-GSCHGDSGGPLV----DANQTLV-GVVNWGEACA- 244
            |..:.|.|.......:.....|...::|. .:|.|||||||:    :..:..| |:.::|..|.
Human   232 ISREMCNSERSYGGIIPNTSFCAGDEDGAFDTCRGDSGGPLMCYLPEYKRFFVMGITSYGHGCGR 296

  Fly   245 IGYPDVFGSVAYYHDWIEQMMTDAGT 270
            .|:|.|:...::|..|:.:....|.|
Human   297 RGFPGVYIGPSFYQKWLTEHFFHAST 322

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5246	NP_650603.1	Tryp_SPc	42..263	CDD:238113	73/242 (30%)
TMPRSS12	NP_872365.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	24..46		1/2 (50%)
		Tryp_SPc	78..316	CDD:238113	73/243 (30%)