Protein Alignment CG5246 and KLK8

DIOPT Version :10

• Sequence 1: NP_650603.1
• Gene: CG5246 / 42072
• FlyBaseID: FBgn0038484
• Length: 272
• Species: Drosophila melanogaster
• Sequence 2: NP_653088.1
• Gene: KLK8 / 11202
• HGNCID: 6369
• Length: 305
• Species: Homo sapiens
• Alignment Length: 266
• Identity: 79/266 - (29%)
• Similarity: 124/266 - (46%)
• Gaps: 41/266 - (15%)

  Fly    25 RRHQLNHHLGHVK-PETRVIGGVDSPTGFAPYQVSIMNTFGEH-VCGGSIIAPQWILTAAHCMEW 87
            |.:.|....||.: .|.:|:||.:......|:|.::..  |:. :|||.::...|:||||||.:
Human    60 RSNPLPPAAGHSRAQEDKVLGGHECQPHSQPWQAALFQ--GQQLLCGGVLVGGNWVLTAAHCKK- 121

  Fly    88 PIQYLKIVTGTVDYT-----RPGAEYLVDGSKIH-C--SHDKPAYHNDIALIHTAKPIVYDDLTQ 144
            |    |......|::     .|..|..|..|..| |  |.|...:::|:.|:............:
Human   122 P----KYTVRLGDHSLQNKDGPEQEIPVVQSIPHPCYNSSDVEDHNHDLMLLQLRDQASLGSKVK 182

  Fly   145 PIKLASKGSLPKVGDKLTLTGWGSTKTWGRYSTQLQKIDLNYIDHDNC-------QSRVRNA--N 200
            ||.||...:.|  |.|.|::||| |.|..|.         |:.|..||       |.:..:|  .
Human   183 PISLADHCTQP--GQKCTVSGWG-TVTSPRE---------NFPDTLNCAEVKIFPQKKCEDAYPG 235

  Fly   201 WLSEGHVCTFTQEGEGSCHGDSGGPLVDANQTLVGVVNWG-EACA-IGYPDVFGSVAYYHDWIEQ 263
            .:::|.||..:.:|..:|.|||||||| .:..|.|:.:|| :.|. ...|.|:.::..|.|||::
Human   236 QITDGMVCAGSSKGADTCQGDSGGPLV-CDGALQGITSWGSDPCGRSDKPGVYTNICRYLDWIKK 299

  Fly   264 MMTDAG 269
            ::...|
Human   300 IIGSKG 305

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5246	NP_650603.1	Tryp_SPc	42..263	CDD:238113	73/240 (30%)
KLK8	NP_653088.1	Tryp_SPc	77..297	CDD:214473	71/239 (30%)