DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4053 and TMPRSS4

DIOPT Version :9

Sequence 1:	NP_650601.2	Gene:	CG4053 / 42070	FlyBaseID:	FBgn0038482	Length:	265	Species:	Drosophila melanogaster
Sequence 2:	XP_005271670.1	Gene:	TMPRSS4 / 56649	HGNCID:	11878	Length:	494	Species:	Homo sapiens

Alignment Length:	239	Identity:	71/239 - (29%)
Similarity:	114/239 - (47%)	Gaps:	20/239 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 RKLLDNRIVGGQEAEDGVAPYQVSIQTIWKTHICSGVILNEQWILTAGHCALDFS-IEDLRIIVG 91
            :.|...|:||.:||.....|:||||| ..|.|:|.|.||:..|:|||.||....: :.:.::..|
Human   198 KSLKTPRVVGVEEASVDSWPWQVSIQ-YDKQHVCGGSILDPHWVLTAAHCFRKHTDVFNWKVRAG 261

  Fly    92 TNDRLEPGQTLFPDEALVHCL---YDIPYVYNNDIALIHVNESIIFNDRTQIVEL---SREQPPA 150
             :|:|..    ||..|:...:   ::..|..:|||||:.:...:.|:...:.:.|   ..|..||
Human   262 -SDKLGS----FPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVRPICLPFFDEELTPA 321

  Fly   151 GSTVTLTGWG-APESSYPTVQYLQTLNLTIIAHEECRERWDFHDGIDIGHICTFTRE-GEGACSG 213
             :.:.:.||| ..::.......|...::.:|....|.....:...:....:|....| |...|.|
Human   322 -TPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMMCAGIPEGGVDTCQG 385

  Fly   214 DSGGPLMWEG---KLVGLVNWGRAC-GVGMPDMYANTVYYQDWI 253
            |||||||::.   .:||:|:||..| |...|.:|.....|.:||
Human   386 DSGGPLMYQSDQWHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWI 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4053	NP_650601.2	Tryp_SPc	34..253	CDD:214473	68/231 (29%)
CG4053	NP_650601.2	Tryp_SPc	35..256	CDD:238113	69/232 (30%)
TMPRSS4	XP_005271670.1	LDLa	58..92	CDD:238060
		SRCR_2	108..197	CDD:295335
		Tryp_SPc	204..429	CDD:214473	68/231 (29%)
		Tryp_SPc	205..432	CDD:238113	69/232 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147486
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840