DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4053 and PRSS54

DIOPT Version :9

Sequence 1:	NP_650601.2	Gene:	CG4053 / 42070	FlyBaseID:	FBgn0038482	Length:	265	Species:	Drosophila melanogaster
Sequence 2:	NP_001073961.1	Gene:	PRSS54 / 221191	HGNCID:	26336	Length:	395	Species:	Homo sapiens

Alignment Length:	282	Identity:	70/282 - (24%)
Similarity:	118/282 - (41%)	Gaps:	64/282 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VRLSLIWLLLLGTSIDVTRGKRLDNRKLLDNRIVGGQEAEDGVA-----PYQVSIQTIWKTHICS 62
            |.|.|:.||...||..|.:..           :..|.:.::|:.     |:.||:|....||:..
Human    16 VLLVLLGLLYSSTSCGVQKAS-----------VFYGPDPKEGLVSSMEFPWVVSLQDSQYTHLAF 69

  Fly    63 GVILNEQWILTAGHCALDFSIEDLRIIVGTNDRLEPGQ---TLFP-DEALVHCLYDIPYVYNNDI 123
            |.||:|.|:|:......  :.:|:.:|||.:: ::|.:   |.:| :..::|..:|...:.|| |
Human    70 GCILSEFWVLSIASAIQ--NRKDIVVIVGISN-MDPSKIAHTEYPVNTIIIHEDFDNNSMSNN-I 130

  Fly   124 ALIHVNESIIFNDRTQ-IVELSR--EQPPAGSTVTLTGWGAPES---SYPTVQYLQTL------- 175
            ||:..:.::.|.:..| |..|.|  ..||......::||. |.|   ::.|:..|:.:
Human   131 ALLKTDTAMHFGNLVQSICFLGRMLHTPPVLQNCWVSGWN-PTSATGNHMTMSVLRKIFVKDLDM 194

  Fly   176 -NLTIIAHEECRERWDFHDGIDIGHICTFTREGEGACSGDSGGPLM--------WEGKLVGLVNW 231
             .|..:...||...              ...|.:.||.||.|.|:|        |  .|.|::|:
Human   195 CPLYKLQKTECGSH--------------TKEETKTACLGDPGSPMMCQLQQFDLW--VLRGVLNF 243

  Fly   232 GRACGVGMPDMYANTVYYQDWI 253
            |.....|: .:|.....|..||
Human   244 GGETCPGL-FLYTKVEDYSKWI 264

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4053	NP_650601.2	Tryp_SPc	34..253	CDD:214473	60/249 (24%)
CG4053	NP_650601.2	Tryp_SPc	35..256	CDD:238113	62/250 (25%)
PRSS54	NP_001073961.1	Tryp_SPc	52..264	CDD:214473	58/233 (25%)
		Tryp_SPc	52..264	CDD:238113	58/233 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	324..348
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147488
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930