Protein Alignment CG4053 and F12

DIOPT Version :10

• Sequence 1: NP_650601.2
• Gene: CG4053 / 42070
• FlyBaseID: FBgn0038482
• Length: 265
• Species: Drosophila melanogaster
• Sequence 2: NP_000496.2
• Gene: F12 / 2161
• HGNCID: 3530
• Length: 615
• Species: Homo sapiens
• Alignment Length: 263
• Identity: 88/263 - (33%)
• Similarity: 123/263 - (46%)
• Gaps: 42/263 - (15%)

  Fly    22 GKRLDNRKLLDN--RIVGGQEAEDGVAPYQVSIQTIWKTHICSGVILNEQWILTAGHCALDF-SI 83
            |:||  ||.|.:  |:|||..|..|..||..::  .|....|:|.::...|:|||.||..|. :.
Human   360 GQRL--RKSLSSMTRVVGGLVALRGAHPYIAAL--YWGHSFCAGSLIAPCWVLTAAHCLQDRPAP 420

  Fly    84 EDLRIIVG---TNDRLEPGQTLFPDEALVHCLYDIPYVYNNDIALIHVNES-----IIFNDRTQI 140
            |||.:::|   .|...||.|||......:|..:. |..|.:|:||:.:.|.     .:.:...|.
Human   421 EDLTVVLGQERRNHSCEPCQTLAVRSYRLHEAFS-PVSYQHDLALLRLQEDADGSCALLSPYVQP 484

  Fly   141 VELSREQPPAG----STVTL---TGWGAP-ESSYPTVQYLQTLNLTIIAHEECRERWDFHDGIDI 197
            |.|     |:|    |..||   .|||.. |.:.....:||...:..::.|.|... |.| |..|
Human   485 VCL-----PSGAARPSETTLCQVAGWGHQFEGAEEYASFLQEAQVPFLSLERCSAP-DVH-GSSI 542

  Fly   198 --GHICT-FTREGEGACSGDSGGPLMWEGK-------LVGLVNWGRACG-VGMPDMYANTVYYQD 251
              |.:|. |...|..||.|||||||:.|.:       |.|:::||..|| ...|.:|.:..||..
Human   543 LPGMLCAGFLEGGTDACQGDSGGPLVCEDQAAERRLTLQGIISWGSGCGDRNKPGVYTDVAYYLA 607

  Fly   252 WIR 254
            |||
Human   608 WIR 610

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4053	NP_650601.2	Tryp_SPc	35..256	CDD:238113	81/248 (33%)
F12	NP_000496.2	FN2	41..88	CDD:128373
		EGF_CA	96..131	CDD:238011
		FN1	133..173	CDD:238018
		EGF	178..206	CDD:394967
		Kringle	217..295	CDD:395005
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	298..359
		Tryp_SPc	373..612	CDD:238113	81/248 (33%)