DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cher and GEX2

DIOPT Version :9

Sequence 1:	NP_001262659.2	Gene:	cher / 42066	FlyBaseID:	FBgn0014141	Length:	2577	Species:	Drosophila melanogaster
Sequence 2:	NP_001330856.1	Gene:	GEX2 / 834974	AraportID:	AT5G49150	Length:	1087	Species:	Arabidopsis thaliana

Alignment Length:	1231	Identity:	231/1231 - (18%)
Similarity:	382/1231 - (31%)	Gaps:	406/1231 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   460 FSAGKGSVDVDIQGPNGEIEKADVRFNNDKNLTYTVSYIPKSEGSHKVAVKFSGRDIPKSPFPVK 524
            |:|...|...|..|    |.|....::||||                   ||...:|  |...:|
plant    18 FNAISISQSTDESG----IPKFTFSWSNDKN-------------------KFKSGEI--SEISIK 57

  Fly   525 VEG----HAGDASKVKVTGPGIQPNGVTIKKPTFFDILAKDAGRGVPE-------------VIII 572
            |.|    |...:...:...|.:..|| .:...|:...::.|.|..:..             .|:|
plant    58 VLGNFDNHGNASLGQRAFKPTVTVNG-KLGNSTYISGVSLDLGEDISNWKIYFTPIMVGIFNIVI 121

  Fly   573 DPANHKTSVAAKVRQLEND-TWRCEYVTALQGLHSVNVFYAGTP-----IPNSPFPVKVAPLSDA 631
            |..|.|...::...::|.. .:....|.:..||  .|||.||..     :|...|
plant   122 DEENFKVLDSSLHFEVEAGLMYPSVSVVSWMGL--ANVFEAGMNASILILPKDAF---------- 174

  Fly   632 RKVRASGRGLQATGVRVGDDADFKIYTEGAGEGEPEVRVIGPGGMNQNVMQSK----VDGNTYEC 692
                  |..:..:|.::    :|:         |..:.:|...|....|:.|.    :.......
plant   175 ------GNNISFSGKKM----EFQ---------EFSLSLISENGSFAGVLNSTHIRWIVSGYISI 220

  Fly   693 HYYPTKEGRYVIMVTFAGQEV--AKSPFEVKVGPKKESSIVA-YGPGLSSGVIGYPAAFVVETNG 754
            .:.....|:::::|....|.:  ...|.||..||...|:.|: :...||:..|......::....
plant   221 DFVLVTSGKFLLLVEKESQTLNGGPLPLEVNSGPLDVSNCVSIWKSELSTWQIFSKMEILLHQKD 285

  Fly   755 ETGAL--GFTVAGPSQAEIECHDNGDGSALVKYHPTAVGEYAVHILCDNEDIPKSPFIAQILPRT 817
            ..|.:  ||........|:|               |.:.                      :|..
plant   286 RFGNIVSGFYEFDADVVEVE---------------TGLS----------------------IPVA 313

  Fly   818 DFHPELVKASGPGLEKNGVTINQPTSFTVDPSKAGNAPLDVVVQDVFGTKLPVELKNNPDGTKKV 882
            ||..|.|:   ||::....|:::|.:|.:..|                     ::|:|    |.:
plant   314 DFQFEYVE---PGIQLMSFTLSEPGNFLLTLS---------------------DMKHN----KSI 350

  Fly   883 TYTPTSGVPHTVEVNYGGVSTPNSPHRVYVGVPVDAAKVQAFGPWLQPGVRPNAATHFNVDAREA 947
                 |.:|:.              :.||:|. .|.::....|.              .::|..|
plant   351 -----SSMPYV--------------YTVYIGY-CDGSRSIVNGS--------------GINASIA 381

  Fly   948 GDAELKVKIIHEETKIEVPCRIIDNEDNTYSVEVIPPSKGAYTTTMTYGGQRVP-----LGEKVV 1007
            |                        |...:||.:    |.||       |...|     |..::|
plant   382 G------------------------ESLGFSVYL----KDAY-------GYPSPVQVDRLQVRIV 411

  Fly  1008 VEQTVDVSKIKVDGLEPTAPLNSLQQFRIITHGLPKADLAVT-ITSPSGNRIKAHIIPTAEGFLV 1071
            :|  :| |.|.:..::|...||          |...:..|.| :....|.|...:::..|..|.|
plant   412 LE--ID-SSIILPTIQPREALN----------GTGSSHQAATPLYEKHGGRASGNLVTQASIFDV 463

  Fly  1072 NFTPTQLGEYLLSICFGGTPIT-PRPFRLQCLTGS---DSNKVQAFG----------------PG 1116
            .:||.:.|.|.:.|..|...:. .:||..:...|.   .:..|..|.                .|
plant   464 TYTPKRTGIYRIFISSGNIVLNGGQPFIKEVYAGEVNVAACSVTQFNGKVPKEIKNEIVVLLLDG 528

  Fly  1117 LERGIVGQPAEFMIDTRGAGQGGLGVTVEGPCEAAINCRDNGDGTCNVAYLPTEAGDYTVNITFN 1181
            ....:..||:....:...|..... .|.|        ..||.|||...:||..|.|.|.:.|:|:
plant   529 FYNPVPSQPSRLKFEITSANTSSF-TTWE--------FVDNNDGTYTGSYLAMEVGTYRMCISFD 584

  Fly  1182 ERHITGSPFQPLIVPVPNLKNTRVSGIGIQPHGVIMNAATDFMVDMSKVGSNIDSG-KLSCAIFD 1245
            .:||...||.         .|...:|...:.:...:|...|..:..:.:.::..:| ..|...|.
plant   585 NKHIQPCPFD---------VNVYSNGYFPRAYDDPVNVWEDESISFNPLENDYFAGDNASMLGFS 640

  Fly  1246 PMGHVLPSKIVQGPTDDIFRIMYTPFEAGRHTIELMYDNIPVPGS-------PFVVNVKSGCDPA 1303
            ..||  .|.:..|   ::.|  |||.:........:|....:.|:       .||:..     |.
plant   641 QPGH--GSLLRDG---NLLR--YTPMKNFSGNDSFLYTIADINGNLAAATVYIFVLTA-----PP 693

  Fly  1304 RCKAYGPGLEKGLTNQKNKFTVETKGAGNGGLSLAIEGPSEAKMTCTDNRDGSCDVDYLATD--- 1365
            :..::..||      |..:..:..:..|..||.::.....|..........||..:..:...
plant   694 QFVSFSGGL------QATEDLISPRYGGFSGLEISYSDLLENISVMVQALSGSVILSPMLMQFRP 752

  Fly  1366 PGEYDITIRFADKHIPGSPFRVLVEETVDPSKVKVYGP--------------------------- 1403
            ||...:::...     |...|||:.|    .:|.|..|
plant   753 PGSGKLSVSNG-----GEDRRVLILE----GQVGVINPALQSIQYLGNENFAGVDSLRLSTKNKN 808

  Fly  1404 GIEHGQVRESV-----PTFFNVDVGEAGPGRIAVKLTNSEGIPVDNLRVEDKGNCIYAV------ 1457
            ||.|..|...|     |.|.||      |..|.::...||.:.....|  ||.|  ::|
plant   809 GINHLDVPVFVEPVNDPPFINV------PQYIMLESNGSESLIFHPER--DKFN--FSVGDPDLV 863

  Fly  1458 -------HYVPPKAGSVLTCQVKFSEVEVPCSPFVMTVFPKS--EPTKVKVKGVNEKKKTPASLP 1513
                   |::           |.|| :|| ...|::|..|..  ..|::|.|.:.:.:
plant   864 NFPGGESHFL-----------VTFS-LEV-TDGFLLTNLPSELINSTELKFKNLFQWQ------- 908

  Fly  1514 AEFEIDTKQAGQADINVAIKNPKGKA--------MQPRLEEVSTGTYVVSFVPDECGTYQC 1566
               .|.|..|....:||.....:.:.        ||..|........|::....:.|.|.|
plant   909 ---PIQTYAAISKHVNVKASGIRFRGTIRQCNDLMQQLLHRGGENGAVLTLKLSDMGNYGC 966

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cher	NP_001262659.2	CH_dFLNA-like_rpt1	175..297	CDD:409160
		CH_dFLNA-like_rpt2	298..415	CDD:409164
		IG_FLMN	432..527	CDD:214720	17/66 (26%)
		IG_FLMN	532..627	CDD:214720	22/113 (19%)
		IG_FLMN	631..724	CDD:214720	14/98 (14%)
		IG_FLMN	728..815	CDD:214720	11/89 (12%)
		IG_FLMN	821..913	CDD:214720	15/91 (16%)
		IG_FLMN	918..1001	CDD:214720	11/82 (13%)
		Filamin	1012..1098	CDD:395505	21/87 (24%)
		IG_FLMN	1109..1196	CDD:214720	24/102 (24%)
		Filamin	1197..1293	CDD:395505	17/103 (17%)
		IG_FLMN	1302..1392	CDD:214720	16/92 (17%)
		IG_FLMN	1395..1490	CDD:214720	29/139 (21%)
		IG_FLMN	1494..1587	CDD:214720	15/81 (19%)
		IG_FLMN	1606..1682	CDD:214720
		IG_FLMN	<1731..1791	CDD:214720
		IG_FLMN	1797..1884	CDD:214720
		IG_FLMN	1978..2067	CDD:214720
		Filamin	<2111..2159	CDD:395505
		IG_FLMN	2172..2260	CDD:214720
		IG_FLMN	2265..2354	CDD:214720
		IG_FLMN	2360..2448	CDD:214720
		IG_FLMN	2488..2577	CDD:214720
GEX2	NP_001330856.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR38537
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100