DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cher and flna

DIOPT Version :9

Sequence 1:NP_001262659.2 Gene:cher / 42066 FlyBaseID:FBgn0014141 Length:2577 Species:Drosophila melanogaster
Sequence 2:NP_001361642.1 Gene:flna / 779840 XenbaseID:XB-GENE-6044838 Length:2644 Species:Xenopus tropicalis


Alignment Length:2639 Identity:1227/2639 - (46%)
Similarity:1610/2639 - (61%) Gaps:263/2639 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly   177 ERDLAEDAQWKKIQQNTFTRWANEHLKTIDRSINNLETDLSDGLRLIALIEVLSQKRM-PKYNKR 240
            |:||||||.||||||||||||.|||||.:::.|.||:.||.||||||||:||||||:| .|||:|
 Frog    30 EKDLAEDAPWKKIQQNTFTRWCNEHLKCVNKRIANLQVDLGDGLRLIALLEVLSQKKMYRKYNQR 94

  Fly   241 PTFRSQKLENVSVALKFLQDEGIKIVNIDSSDIVDCKLKLILGLIWTLILHYSISMPMWDGEDDK 305
            ||||..:||||||||:||..|.||:|:|||..|||..|||||||||||||||||||||||.|:|:
 Frog    95 PTFRQMQLENVSVALEFLDRENIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWDEEEDE 159

  Fly   306 QLNGSGHTPKQRLLNWIHAKIPDLPINNFTNDWTTGKAVGALVDACAPGLCPDWELWDPKDAVQN 370
            :  ....|||||||.||..|:|.||:.||:.||.:|:|:|||||:|||||||||:.||....|.|
 Frog   160 E--AKKQTPKQRLLGWIQNKLPHLPVTNFSRDWQSGRALGALVDSCAPGLCPDWDSWDATKPVDN 222

  Fly   371 ASEAMGLADDWLNVRQLIKPEELVNPNVDEQSMMTYLSQYPNSKLKTGAPLRPKTNPNSIPPPRV 435
            |.|||..|||||.:.|:|.|||:|:|||||.|:||||||:|.:|||.|||||||.||.     :.
 Frog   223 AREAMQQADDWLGIPQVITPEEIVDPNVDEHSVMTYLSQFPKAKLKPGAPLRPKLNPK-----KA 282

  Fly   436 RAYGPGIEPIGPVVGAPANFTVETFSAGKGSVDVDIQGPNGEIEKADVRFNNDKNLTYTVSYIPK 500
            |||||||||.|.:|...|.|||||.|||.|.|.|.::.|.|..|:|.|..|||||.|::|.||||
 Frog   283 RAYGPGIEPTGNMVKKRAEFTVETISAGMGEVLVYVEDPAGHREEAKVTANNDKNRTFSVYYIPK 347

  Fly   501 SEGSHKVAVKFSGRDIPKSPFPVKVEGHAGDASKVKVTGPGIQPNGVTIKKPTFFDILAKDAGRG 565
            ..|.|||.|.|:|:.|.||||.|.|:...||||||...|||::|:|....|.|:|:|....||.|
 Frog   348 VTGLHKVTVLFAGQHIAKSPFEVNVDKSHGDASKVTAQGPGLEPSGNIANKTTYFEIFTAGAGVG 412

  Fly   566 VPEVIIIDPANHKTSVAAKVRQLENDTWRCEYVTALQGLHSVNVFYAGTPIPNSPFPVKVAPLSD 630
            ..||.|:||...|.:...::....:.|:||.|...::|::::.:.:||..||.||:.|.:....:
 Frog   413 EIEVTIVDPNGKKDTADVQLEDKGSSTYRCTYKPTMEGVYTIYITFAGVQIPKSPYTVTIGQACN 477

  Fly   631 ARKVRASGRGLQATGVRVGDDADFKIYTEGAGEGEPEVRVIGPGGMNQNVMQSKVDGNTYECHYY 695
            ....||.|||||..||||.:.||||:||:|||.||.:|.|.||.|..:.|.|..:....|...||
 Frog   478 PAACRAVGRGLQPKGVRVKETADFKVYTKGAGSGELKVVVKGPKGTEERVKQKDLGDGVYAFEYY 542

  Fly   696 PTKEGRYVIMVTFAGQEVAKSPFEVKVGPK-KESSIVAYGPGLSSGVIGYPAAFVVETNG-ETGA 758
            |...|.|::.:|:.||.:.:||||||||.: .:..:.|:||||..||:|..|.||||..| :.|.
 Frog   543 PATPGNYIVTITWGGQNIPRSPFEVKVGTECGQQRVRAWGPGLEGGVVGKSADFVVEAIGDDVGT 607

  Fly   759 LGFTVAGPSQAEIECHDNGDGSALVKYHPTAVGEYAVHILCDNEDIPKSPFIAQILPR-TDFHPE 822
            |||:|.|||||:|||.|.||||..|:|.|...||||||:||:||||..|||:|.|.|. .||:||
 Frog   608 LGFSVEGPSQAKIECDDKGDGSCDVRYWPLEPGEYAVHVLCNNEDIKLSPFMADIKPAPKDFYPE 672

  Fly   823 LVKASGPGLEKNGVTINQPTSFTVDPSKAGNAPLDVVVQDVFGTKLPVELKNNPDGTKKVTYTPT 887
            .|||.||||||.|:.||:|..||||....|.|||.|.|||..||.:.|..|:|.:||...:|.|.
 Frog   673 KVKAYGPGLEKTGLAINKPAEFTVDAKLGGKAPLKVSVQDSEGTPVDVTTKDNGNGTYSCSYLPK 737

  Fly   888 SGVPHTVEVNYGGVSTPNSPHRVYVGVPVDAAKVQAFGPWL-QPGVRPNAATHFNVDAREAGDAE 951
            ..:.||..|::|||:.||||.|:.:|......||:.:||.: :.|::.:..|:|.||..|||..:
 Frog   738 KPLKHTAVVSWGGVNIPNSPFRMTIGAGSHPNKVKVYGPGVAKTGLKAHEPTYFTVDCTEAGQGD 802

  Fly   952 ------------------------------------------------------------LKVKI 956
                                                                        :||..
 Frog   803 VSIGIKCAPGVVGPAEADIDFDIIRNDNDTFTVKYTPPGAGSYTIMVLFADQATPMSPFRIKVDP 867

  Fly   957 IHEETKIEV------------------------------------PCR--------IIDNEDNTY 977
            .|:.:|::.                                    |.:        :|||.||||
 Frog   868 SHDASKVKAEGPGLNRSGVEIGKPTHFTVNTKAAGKANLDVQFTGPAKGEAVKDFDVIDNHDNTY 932

  Fly   978 SVEVIPPSKGAYTTTMTYGGQRVPLGEKVV-VEQTVDVSKIKVDGLEPTAPLNSLQQFRIITHGL 1041
            :|:..|..:|.....:||||..:|.....| :..|:|:|||||.||.....:...|:|.:.:.|.
 Frog   933 TVKYTPVQQGNMGVNVTYGGDHIPKSPFTVGIAPTLDLSKIKVSGLGDKVEVGKDQEFTVKSRGA 997

  Fly  1042 -PKADLAVTITSPSGNRIKAHIIP--TAEGFLVNFTPTQLGEYLLSICFGGTPITPRPFRLQCLT 1103
             .:..:|..||.||...:...:.|  :.:...|.|.|.:.|.|.:.:.:.|.||...||.::.:.
 Frog   998 GGQGKVACKITGPSNKSVPCKVEPGLSPDNSTVKFIPREEGPYEVDVTYDGVPIPGSPFPVEAVP 1062

  Fly  1104 GSDSNKVQAFGPGLERGIVGQPAEFMIDTRGAGQGGLGVTVEGPCEAAINCRDNGDGTCNVAYLP 1168
            .::.:||:||||||:.|.||..|.|.|||:||||||||:||||||||.|.|.|||||||:|:|||
 Frog  1063 STNPSKVKAFGPGLKGGSVGSSAPFTIDTKGAGQGGLGLTVEGPCEAKIECLDNGDGTCSVSYLP 1127

  Fly  1169 TEAGDYTVNITFNERHITGSPFQPLIVP------------------------------------- 1196
            ||.|||.:||.|.:.||.||||:..:.|                                     
 Frog  1128 TERGDYNINILFADTHIPGSPFKAKVEPCFDPSKVTCSGPGLEHAQVGEAGKFNVDCSNAGSAEL 1192

  Fly  1197 ----------------------------------------------VPNL------------KNT 1203
                                                          |||.            ...
 Frog  1193 TIEIISDNGMQAEVHIQDNGDGTYTITYIPLYPGVYTITIKYGGQMVPNFPSKLQVKPAIDTSGV 1257

  Fly  1204 RVSGIGIQPHGVIMNAATDFMVD---MSKVGSNIDSGKLSCAIFDPMGHVLPSKIVQGPTDDIFR 1265
            :|.|.|::..||...|.|||.||   ::|.|    ...|...:.:|.|: .....||...|..::
 Frog  1258 KVYGPGVEGKGVFREATTDFNVDARALTKSG----GPHLKTVVSNPSGN-FTEAFVQDNGDGTYK 1317

  Fly  1266 IMYTPFEAGRHTIELMYDNIPVPGSPFVVNVKSGCDPARCKAYGPGLEKGLTNQKNKFTVETKGA 1330
            :.|||:|.|.|:::::||..|.|.|||||.|..||||:|.:.:|||:..|.|||.|||||||:||
 Frog  1318 VEYTPYEEGIHSVDVIYDGSPAPKSPFVVPVTEGCDPSRVRVHGPGIVSGTTNQPNKFTVETRGA 1382

  Fly  1331 GNGGLSLAIEGPSEAKMTCTDNRDGSCDVDYLATDPGEYDITIRFADKHIPGSPFRVLVEETVDP 1395
            |.|||.||:||||||||:||||:||||.|:|:..:||.|::.:.:....:|||||:|.|.:.||.
 Frog  1383 GTGGLGLAVEGPSEAKMSCTDNKDGSCSVEYVPYEPGTYNLNVTYGGHQVPGSPFKVPVSDVVDS 1447

  Fly  1396 SKVKVYGPGIEHGQVRESVPTFFNVDVGEAGPGRIAVKLTNSEGIPVDNLRVEDKGNCIYAVHYV 1460
            ||||..|||:..|.||.:||..|:||..:||...:.||:...:|| |:.:.:.|.||.:..|:||
 Frog  1448 SKVKCTGPGLSPGLVRANVPQSFSVDTSKAGVAPLQVKVQGPKGI-VEPVEIVDNGNGVQTVNYV 1511

  Fly  1461 PPKAGSVLTCQVKFSEVEVPCSPFVMTVFPKSEPTKVKVKGVN-EKKKTPASLPAEFEIDTKQAG 1524
            |.:.|. ....|.:.:.|:|.|||.:.|.|..:.:|||..|.. .....|||||.||.||.|.||
 Frog  1512 PTREGP-YNISVLYGDDEIPHSPFKVRVLPTHDASKVKASGPGLNTTGVPASLPVEFTIDAKDAG 1575

  Fly  1525 QADINVAIKNPKGKAMQPRLEEVSTGTYVVSFVPDECGTYQCSIKYGDKEIEGSPFKLEAFPTGE 1589
            :..:.|.|.:|:||..:..:.:...|||.||:|||..|.|...||||..||..||:::.|.|||:
 Frog  1576 EGLLAVQITDPEGKPKKATIRDNQDGTYTVSYVPDMTGRYTILIKYGGDEIPYSPYRIRALPTGD 1640

  Fly  1590 AKKCKLVEQ----------APKIQTSGSQSHLKVDAREAGDGAVTCKITNKAGSEIVDIDVIE-K 1643
            |.||.:...          .|.||. |.::.:.|||:.||.|.|||.:....|:| ||:||:| :
 Frog  1641 ASKCTVTVSIGGHGLGAGIGPTIQI-GEETVITVDAKAAGKGKVTCTVCTPDGTE-VDVDVVENE 1703

  Fly  1644 DGFFDILYALNDPGDYDINVKFGGKDIPNGSFSIKAVESIEQYSHSEYIEE-----HTTKVVQQT 1703
            ||.|||.|....||.|.|.|:|||:.|||..|.:.|::. ||....:.:::     :....:||.
 Frog  1704 DGTFDIFYTAPQPGKYVICVRFGGEHIPNSPFQVTALDG-EQMMPQQMVQQQLAPPYAYPGMQQP 1767

  Fly  1704 TQSEL----VNGKSEITYRSVAFE-KLPLPTTGGNVTAEVRMPSGKVDKPVIQDNRDGTVSVKYD 1763
            ..::.    |||......|  .|: .:|.....|.:|.|||||||||.||.|.||:||||:|:|.
 Frog  1768 WATDRPVMGVNGLDVAGLR--PFDLVIPFTIKKGEITGEVRMPSGKVAKPDITDNKDGTVTVRYA 1830

  Fly  1764 PREEGSHELVVKYNGEPVQGSPFKFHVDSITSGYVTAYGPGLTHGVTGEPANFTISTKGASAGGL 1828
            |.|.|.||:.:||:|..:.|||.:|:||.:.||:||||||||.||...:||.||::||.|..|||
 Frog  1831 PTEAGLHEMDIKYDGMHIPGSPLQFYVDYVNSGHVTAYGPGLIHGTVNKPAVFTVNTKDAGEGGL 1895

  Fly  1829 TMAVEGPSKADINYHDNKDGTVSVQYLPTAPGEYQVSVRFGDKHIKGSPYFAKITGEGRKR-NQI 1892
            ::|:||||||:|:..||:|||.:|.|||..||:|.:.|::.:|||.|||:.|||||:...| :|:
 Frog  1896 SLAIEGPSKAEISCTDNQDGTCTVSYLPVLPGDYNILVKYNNKHIPGSPFVAKITGDDSMRMSQL 1960

  Fly  1893 SVGSCSEVTMPGDITDDDLRALNASIQAPSGLEEPCFLKRMPTGNIGISFTPREIGEHLVSVKRL 1957
            .|||.:::  |.:|.:.||..|.|::.:|||.||||.|||:..|::||||.|:|.|||:||:|:.
 Frog  1961 KVGSAADI--PLNIVETDLSQLTATVTSPSGREEPCLLKRLRNGHVGISFVPKETGEHIVSIKKN 2023

  Fly  1958 GKHINNSPFKVTVCEREVGDAKKVKVSGTGLKEGQTHADNIFSVDTRNAGFGGLSVSIEGPSKAE 2022
            |.||.|||..|.:.:.|:|||.:|.|||.||.||:|.....|.:|||.||:||||:|||||||.:
 Frog  2024 GIHIPNSPITVMISQSEIGDASRVIVSGQGLTEGRTFEPAEFIIDTREAGYGGLSLSIEGPSKVD 2088

  Fly  2023 IQCTDKDDGTLNISYKPTEPGYYIVNLKFADHHVEGSPFTVKVAGEGSNRKREKIQRERDAVPIT 2087
            |...|.:|||..::|.|||||.||:|:||||.||.||||:|||.|||  |.:|.|.|.|.|..:.
 Frog  2089 INTEDLEDGTCKVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEG--RMKESITRRRTAPSVA 2151

  Fly  2088 EIGSQCKLTFKMPGITSFDLAACVTSPSNVTEDAEIQEVEDGLYAVHFVPKELGVHTVSVRYSEM 2152
            .|||||.|:.|:|.|:..|:.|.|||||....||||.|.|:..|.:.|||.|:|||||||:|...
 Frog  2152 NIGSQCDLSLKIPEISIHDMTAQVTSPSGKIHDAEIMESENNTYCIRFVPSEMGVHTVSVKYKGQ 2216

  Fly  2153 HIPGSPFQFTVGPLRDSGSHLVKAGGSGLERGVVGEAAEFNVWTREAGGGSLAISVEGPSKADIE 2217
            |:||||||||||||.:.|:|.|:|||.||||..||..|||::||||||.|.|:|:|||||||:|.
 Frog  2217 HVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEVGTPAEFSIWTREAGAGGLSIAVEGPSKAEIA 2281

  Fly  2218 FKDRKDGSCDVSYKVTEPGEYRVGLKFNDRHIPDSPFKVYVSPDAGDAHKLEVQQFPQGNIQADA 2282
            |:|||||||.|||.|.|||:|.|.:||||.|||||||.|.|...:.||.:|.|....:..::.:.
 Frog  2282 FEDRKDGSCGVSYIVQEPGDYEVSVKFNDEHIPDSPFVVPVGSTSDDARRLTVSSLQESGLKVNQ 2346

  Fly  2283 PYQFMVRKNGAKGELDAKIVAPSGTDDDCFIQVIDGEMYSVRFYPRENGIHAIHVKFNGVHIPDS 2347
            |..|.|..|||||.||||:.:|||..::|.:..||.:.|:|||.|||||::.:.|||||.|||.|
 Frog  2347 PASFAVSLNGAKGVLDAKVHSPSGALEECCVTEIDEDKYAVRFIPRENGLYIVDVKFNGSHIPGS 2411

  Fly  2348 PFRIKVGK--DVADPAAVHASGNGLDEVKTGHKADFIINTCNAGVGTLAVSIDGPSKVAMDCTEV 2410
            ||:|:||:  ...||..|.|.|.||:...||..|:||:||..||.|.|.|:|||||||.|||.|.
 Frog  2412 PFKIRVGEPGQAGDPGMVSAYGPGLEGGTTGSAAEFIVNTTKAGPGALTVTIDGPSKVKMDCQEC 2476

  Fly  2411 EEGYKVRYTPLLPGEHYITVKYNN-MHIVGSPFKVNATGDKL-ADEGAQETSTVIVETVQKVAKG 2473
            .|||||.|||:.||.:.|::||.. .||||||||...||.:| ......|:|:|.|::|.|....
 Frog  2477 AEGYKVTYTPMAPGSYLISIKYGGPYHIVGSPFKAKVTGPRLVTSHSLHESSSVFVDSVTKSEAF 2541

  Fly  2474 GKNTGVHLPTFKSDASKVVSKGMGLKKAYIGKQNQFSISATDAGNNILYVGMYGPKGPCEEFHVK 2538
            .::...  |...|||||||:||:||.||::|::|.|::..:.||||:|.||::|||.||||..||
 Frog  2542 TQHAAA--PRIASDASKVVAKGLGLNKAFVGQKNSFTVDCSKAGNNMLLVGVHGPKTPCEEIVVK 2604

  Fly  2539 HAGHNNYNVQYLVRDRGQYVLLIKWGEEHIPGSPFQIDV 2577
            |.|:..|||.||::|:|.|:|::|||:|||.|||:.:.|
 Frog  2605 HLGNRLYNVTYLLKDKGDYILVVKWGDEHILGSPYHVSV 2643

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cherNP_001262659.2 CH_dFLNA-like_rpt1 175..297 CDD:409160 90/120 (75%)
CH_dFLNA-like_rpt2 298..415 CDD:409164 70/116 (60%)
IG_FLMN 432..527 CDD:214720 53/94 (56%)
IG_FLMN 532..627 CDD:214720 34/94 (36%)
IG_FLMN 631..724 CDD:214720 45/92 (49%)
IG_FLMN 728..815 CDD:214720 52/87 (60%)
IG_FLMN 821..913 CDD:214720 47/91 (52%)
IG_FLMN 918..1001 CDD:214720 31/187 (17%)
Filamin 1012..1098 CDD:395505 26/88 (30%)
IG_FLMN 1109..1196 CDD:214720 59/86 (69%)
Filamin 1197..1293 CDD:395505 34/110 (31%)
IG_FLMN 1302..1392 CDD:214720 52/89 (58%)
IG_FLMN 1395..1490 CDD:214720 37/94 (39%)
IG_FLMN 1494..1587 CDD:214720 40/93 (43%)
IG_FLMN 1606..1682 CDD:214720 36/76 (47%)
IG_FLMN <1731..1791 CDD:214720 34/59 (58%)
IG_FLMN 1797..1884 CDD:214720 50/86 (58%)
IG_FLMN 1978..2067 CDD:214720 54/88 (61%)
Filamin <2111..2159 CDD:395505 28/47 (60%)
IG_FLMN 2172..2260 CDD:214720 61/87 (70%)
IG_FLMN 2265..2354 CDD:214720 42/88 (48%)
IG_FLMN 2360..2448 CDD:214720 50/88 (57%)
IG_FLMN 2488..2577 CDD:214720 50/88 (57%)
flnaNP_001361642.1 SAC6 39..>265 CDD:227401 155/227 (68%)
IG_FLMN 279..373 CDD:214720 53/98 (54%)
IG_FLMN 379..475 CDD:214720 34/95 (36%)
IG_FLMN 478..570 CDD:214720 44/91 (48%)
IG_FLMN 576..665 CDD:214720 52/88 (59%)
IG_FLMN 671..765 CDD:214720 48/93 (52%)
IG_FLMN 768..868 CDD:214720 14/99 (14%)
IG_FLMN 871..967 CDD:214720 18/95 (19%)
IG_FLMN 971..1063 CDD:214720 26/91 (29%)
IG_FLMN 1066..1155 CDD:214720 59/88 (67%)
IG_FLMN 1159..1251 CDD:214720 3/91 (3%)
IG_FLMN 1255..1351 CDD:214720 35/100 (35%)
IG_FLMN 1354..1443 CDD:214720 52/88 (59%)
IG_FLMN 1448..1541 CDD:214720 37/94 (39%)
IG_FLMN 1544..1638 CDD:214720 40/93 (43%)
IG_FLMN 1664..1742 CDD:214720 37/79 (47%)
IG_FLMN <1794..1858 CDD:214720 34/63 (54%)
IG_FLMN 1865..1951 CDD:214720 50/85 (59%)
IG_FLMN 2044..2133 CDD:214720 54/88 (61%)
IG_FLMN 2235..2323 CDD:214720 60/87 (69%)
IG_FLMN 2329..2420 CDD:214720 44/90 (49%)
IG_FLMN 2426..2516 CDD:214720 51/89 (57%)
IG_FLMN 2554..2643 CDD:214720 50/88 (57%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 156 1.000 Domainoid score I4124
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1620 1.000 Inparanoid score I78
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D24684at33208
OrthoFinder 1 1.000 - - FOG0001288
OrthoInspector 1 1.000 - - otm48636
Panther 1 1.100 - - O PTHR38537
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X791
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
77.160

Return to query results.
Submit another query.