DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cher and Flnc

DIOPT Version :9

Sequence 1:NP_001262659.2 Gene:cher / 42066 FlyBaseID:FBgn0014141 Length:2577 Species:Drosophila melanogaster
Sequence 2:XP_036008175.1 Gene:Flnc / 68794 MGIID:95557 Length:2747 Species:Mus musculus


Alignment Length:2755 Identity:1240/2755 - (45%)
Similarity:1628/2755 - (59%) Gaps:376/2755 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly   171 DEDMEAERDLAEDAQWKKIQQNTFTRWANEHLKTIDRSINNLETDLSDGLRLIALIEVLSQKRM- 234
            ||....|:||||||.||||||||||||.|||||.:.:.:.:|:.|||||||||||:|||||||| 
Mouse    20 DEMPSTEKDLAEDAPWKKIQQNTFTRWCNEHLKCVGKRLTDLQRDLSDGLRLIALLEVLSQKRMY 84

  Fly   235 PKYNKRPTFRSQKLENVSVALKFLQDEGIKIVNIDSSDIVDCKLKLILGLIWTLILHYSISMPMW 299
            .|::.||.||..|||||||||:||:.|.||:|:|||..|||..||||||||||||||||||||||
Mouse    85 RKFHPRPNFRQMKLENVSVALEFLEREHIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMW 149

  Fly   300 DGEDDKQLNGSGHTPKQRLLNWIHAKIPDLPINNFTNDWTTGKAVGALVDACAPGLCPDWELWDP 364
            :.|||:  :....|||||||.||..|:|.|||.||..||..|||:|||||.||||||||||.|||
Mouse   150 EDEDDE--DARKQTPKQRLLGWIQNKVPQLPITNFNRDWQDGKALGALVDNCAPGLCPDWEAWDP 212

  Fly   365 KDAVQNASEAMGLADDWLNVRQLIKPEELVNPNVDEQSMMTYLSQYPNSKLKTGAPLRPKTNPNS 429
            ...||||.|||..|||||.|.|:|.|||:|:|||||.|:||||||:|.:|||.|||:|.|    .
Mouse   213 NQPVQNAREAMQQADDWLGVPQVIAPEEIVDPNVDEHSVMTYLSQFPKAKLKPGAPVRSK----Q 273

  Fly   430 IPPPRVRAYGPGIEPIGPVVGAPANFTVETFSAGKGSVDVDIQGPNGEIEKADVRFNNDKNLTYT 494
            :.|.:..||||||||.|..|..||:|||:|..||.|.|.|.|:.|.|..|:|.|..||||:.||.
Mouse   274 LNPKKAIAYGPGIEPQGNTVLQPAHFTVQTVDAGVGEVLVYIEDPEGHTEEAKVVPNNDKDRTYA 338

  Fly   495 VSYIPKSEGSHKVAVKFSGRDIPKSPFPVKVEGHAGDASKVKVTGPGIQPNGVTIKKPTFFDILA 559
            |||:||..|.|||.|.|:|::|.:|||.|.|....|||:||...|||::|.|....|||:|||..
Mouse   339 VSYVPKVAGLHKVTVLFAGQNIERSPFEVNVGMALGDANKVSARGPGLEPVGNVANKPTYFDIYT 403

  Fly   560 KDAGRGVPEVIIIDPANHKTSVAAKVRQLENDTWRCEYVTALQGLHSVNVFYAGTPIPNSPFPV- 623
            ..||.|...|:|:||...:.:|...:....::|:||.|...::|.|:|:|.:||.||..||||| 
Mouse   404 AGAGTGDVAVVIVDPQGRRDTVEVALEDKGDNTFRCTYRPVMEGPHTVHVAFAGAPITRSPFPVH 468

  Fly   624 --------------------KVAPLSDARKVRASGRGLQATGVRVGDDADFKIYTEGAGEGEPEV 668
                                :|||..:....||||||||..||||.:.||||::|:|||.||.:|
Mouse   469 VAEVPLPTPTPSVPIVHQAKRVAPPCNPNACRASGRGLQPKGVRVKEVADFKVFTKGAGSGELKV 533

  Fly   669 RVIGPGGMNQNVMQSKVDGNTYECHYYPTKEGRYVIMVTFAGQEVAKSPFEVKVGPKKESSIV-A 732
            .|.||.|..:.|...:.....:||.|||...|:||:.:|:.|..:.:|||||:|.|:..:..| |
Mouse   534 TVKGPKGTEEPVKVREAGDGVFECEYYPVVPGKYVVTITWGGYAIPRSPFEVQVSPEAGAQKVRA 598

  Fly   733 YGPGLSSGVIGYPAAFVVETNG-ETGALGFTVAGPSQAEIECHDNGDGSALVKYHPTAVGEYAVH 796
            :||||.:|.:|..|.||||..| |.|.|||::.|||||:|||.|.||||..|:|.||..||||||
Mouse   599 WGPGLETGQVGKSADFVVEAIGTEVGTLGFSIEGPSQAKIECDDKGDGSCDVRYWPTEPGEYAVH 663

  Fly   797 ILCDNEDIPKSPFIAQILPR-TDFHPELVKASGPGLEKNGVTINQPTSFTVDPSKAGNAPLDVVV 860
            ::||:|||..|||||.|.|. .|..|:.|||.|||||..|..:::|..||:|...||...|.:..
Mouse   664 VICDDEDIRDSPFIAHIQPAPPDCFPDKVKAFGPGLEPTGCIVDRPAEFTIDARAAGKGDLKLYA 728

  Fly   861 QDVFGTKLPVELKNNPDGTKKVTYTPTSGVPHTVEVNYGGVSTPNSPHRVYVGVPVDAAKVQAFG 925
            ||..|..:.:::..|.|||.:.:|.||..:.||:.|::|||:.|.||.||.||......:|:.:|
Mouse   729 QDADGCPIDIKVIPNGDGTFRCSYVPTKPIKHTIIVSWGGVNVPKSPFRVNVGEGSHPERVKVYG 793

  Fly   926 PWLQ-PGVRPNAATHFNVDAREAGDAELKVKI-----IHEETKIEVPCRIIDNEDNTYSVEVIPP 984
            |.:: .|::.|..|:|.||..|||..::.:.|     :....:.::...||.|:::|::|:..||
Mouse   794 PGVEKTGLKANEPTYFTVDCSEAGQGDVSIGIKCAPGVVGPVEADIDFDIIKNDNDTFTVKYTPP 858

  Fly   985 SKGAYT----------------------------------------------------------- 990
            ..|.||                                                           
Mouse   859 GAGHYTIMVLFANQEIPASPFHIKVDPSHDASKVKAEGPGLSRTGVEVGKPTHFTVLTKGAGKAK 923

  Fly   991 ----------------------------------------TTMTYGGQRVPLGEKVV-VEQTVDV 1014
                                                    .|:||||..||....|| |...:|:
Mouse   924 LDVHFAGAAKGEAVRDFEIIDNHDYSYTVKYTAVQQGNMAVTVTYGGDPVPKSPFVVNVAPPLDL 988

  Fly  1015 SKIKVDGLEPTAPLNSLQQFRIITHGL-PKADLAVTITSPSGNRIKAHIIP--TAEGFLVNFTPT 1076
            ||:||.||.....:...|.|.:.|.|. .:..|.|.:||||...|...:.|  .||...|.:.|.
Mouse   989 SKVKVQGLNSKVAVGQEQAFSVNTRGAGGQGQLDVRMTSPSRRPIPCKLEPGGGAEAQAVRYMPP 1053

  Fly  1077 QLGEYLLSICFGGTPITPRPFRLQCLTGSDSNKVQAFGPGLERGIVGQPAEFMIDTRGAGQGGLG 1141
            :.|.|.:.|.:.|.|:...||.::.:...|.:||.|:||||:.|:||.||.|.|||:|||.||||
Mouse  1054 EEGPYKVDITYDGHPVPGSPFAVEGVLPPDPSKVCAYGPGLKGGLVGTPAPFSIDTKGAGTGGLG 1118

  Fly  1142 VTVEGPCEAAINCRDNGDGTCNVAYLPTEAGDYTVNITFNERHITGSPFQPLIVPV--------- 1197
            :||||||||.|.|:|||||:|.|:|||||.|:||:||.|.|.||.||||:..|.||         
Mouse  1119 LTVEGPCEAKIECQDNGDGSCAVSYLPTEPGEYTINILFAEAHIPGSPFKATIQPVFDPSKVRAS 1183

  Fly  1198 -PNLK------------------------------------------------------------ 1201
             |.|:                                                            
Mouse  1184 GPGLERGKAGEAATFTVDCSEAGEAELTIEILSDAGVKAEVLIQNNADGTYHITYSPAFPGTYTI 1248

  Fly  1202 -------------------------NTRVSGIGIQPHGVIMNAATDFMVD---MSKVGSNIDSGK 1238
                                     ..:|||.|::||||:....|:|.||   ::..|.|    .
Mouse  1249 TIKYGGHPIPKFPTRVHVQPAVDTSGIKVSGPGVEPHGVLREVTTEFTVDARSLTATGGN----H 1309

  Fly  1239 LSCAIFDPMGHVLPSKIVQGPTDDIFRIMYTPFEAGRHTIELMYDNIPVPGSPFVVNVKSGCDPA 1303
            ::..:.:|.|....:.:... .|..:|:.||.:|.|.|.:|::||.:.||.|||.|.|..||||.
Mouse  1310 VTARVLNPSGAKTDTYVTDN-GDGTYRVQYTAYEEGVHLVEVLYDEVAVPKSPFRVGVTEGCDPT 1373

  Fly  1304 RCKAYGPGLEKGLTNQKNKFTVETKGAGNGGLSLAIEGPSEAKMTCTDNRDGSCDVDYLATDPGE 1368
            |.:|:|||||.||.|:.|:|||||:|||.|||.|||||||||||:|.||:||||.|:|:...||:
Mouse  1374 RVRAFGPGLEGGLVNKANRFTVETRGAGTGGLGLAIEGPSEAKMSCKDNKDGSCTVEYIPFTPGD 1438

  Fly  1369 YDITIRFADKHIPGSPFRVLVEETVDPSKVKVYGPGIEHGQVRESVPTFFNVDVGEAGPGRIAVK 1433
            ||:.|.|..:.||||||||.|::.|||.|||..|||:..| ||..||..|.||..:||...:.|.
Mouse  1439 YDVNITFGGQPIPGSPFRVPVKDVVDPGKVKCSGPGLGTG-VRARVPQTFTVDCSQAGRAPLQVA 1502

  Fly  1434 LTNSEGI--PVDNLRVEDKGNCIYAVHYVPPKAGSVLTCQVKFSEVEVPCSPFVMTVFPKSEPTK 1496
            :....|:  ||:   |.|.|:..:.|||.|...|. .|..||:::.|||.|||.:.|.|..:.:|
Mouse  1503 VLGPTGVAEPVE---VRDNGDGTHTVHYTPATDGP-YTVAVKYADQEVPRSPFKIKVLPSHDASK 1563

  Fly  1497 VKVKGVN-EKKKTPASLPAEFEIDTKQAGQADINVAIKNPKGKAMQPRLEEVSTGTYVVSFVPDE 1560
            |:..|.. .....|||||.||.||.:.|||..:.|.|.:|:||..:..:.:...|||.||::||.
Mouse  1564 VRASGPGLNASGIPASLPVEFTIDARDAGQGLLTVQILDPEGKPKKANIRDNGDGTYTVSYLPDM 1628

  Fly  1561 CGTYQCSIKYGDKEIEGSPFKLEAFPTGEAKKCKLVEQ----------APKIQTSGSQSHLKVDA 1615
            .|.|..:||||..||..|||::.|.|||:|.||.:...          .|:||. |.::.:.|||
Mouse  1629 SGRYTITIKYGGDEIPYSPFRIHALPTGDASKCLVTVSIGGHGLGACLGPRIQI-GEETVITVDA 1692

  Fly  1616 REAGDGAVTCKITNKAGSEIVDIDVIEK-DGFFDILYALNDPGDYDINVKFGGKDIPNGSFSIKA 1679
            :.||.|.|||.::...|:|: |:||:|. ||.|||.|...:||.|.|.::|||:.|||..|.:.|
Mouse  1693 KAAGKGKVTCTVSTPDGAEL-DVDVVENHDGTFDIYYTAPEPGKYVITIRFGGEHIPNSPFHVLA 1756

  Fly  1680 VESIEQYSHSEYIEEHTTKVVQQTTQSELVNGKSEITYRS----VAFEKL-----------PLPT 1729
            .:.:      .::||....:..:...:.|..|.....:.:    |..|.|           |...
Mouse  1757 CDPL------PHVEEPAEMLQMRQPYAPLRPGTCPTHWATEEPVVPVEPLESMLRPFNLVIPFTV 1815

  Fly  1730 TGGNVTAEVRMPSGKVDKPVIQDNRDGTVSVKYDPREEGSHELVVKYNGEPVQGSPFKFHVDSIT 1794
            ..|.:|.||||||||..:|.|.||:|||::|:|.|.|:|.|::.:||:|..:.|||.:|:||:|.
Mouse  1816 QKGELTGEVRMPSGKTARPNITDNKDGTITVRYAPTEKGLHQMGIKYDGNHIPGSPLQFYVDAIN 1880

  Fly  1795 SGYVTAYGPGLTHGVTGEPANFTISTKGASAGGLTMAVEGPSKADINYHDNKDGTVSVQYLPTAP 1859
            |.:|:||||||:||:..:||.|||.||.|..|||::||||||||:|...||||||.:|.||||||
Mouse  1881 SRHVSAYGPGLSHGMVNKPATFTIVTKDAGEGGLSLAVEGPSKAEITCKDNKDGTCTVSYLPTAP 1945

  Fly  1860 GEYQVSVRFGDKHIKGSPYFAKITGEGRKR-NQISVGSCSEVTMPGDITDDDLRALNASIQAPSG 1923
            |:|.:.|||.||||.|||:.|||||:...| :|::||:.::|::  .||:.||..|.|||:||||
Mouse  1946 GDYSIIVRFDDKHIPGSPFTAKITGDDSMRTSQLNVGTSTDVSL--KITEGDLSQLTASIRAPSG 2008

  Fly  1924 LEEPCFLKRMPTGNIGISFTPREIGEHLVSVKRLGKHINNSPFKVTVCEREVGDAKKVKVSGTGL 1988
            .||||.|||:|..:|||||||:|:|||:|||::.|||:.|||||:.|...|:|||.||:|.|.||
Mouse  2009 NEEPCLLKRLPNRHIGISFTPKEVGEHVVSVRKSGKHVTNSPFKILVGPSEIGDASKVRVWGKGL 2073

  Fly  1989 KEGQTHADNIFSVDTRNAGFGGLSVSIEGPSKAEIQCTDKDDGTLNISYKPTEPGYYIVNLKFAD 2053
            .||||.....|.|||||||:|||.:|||||||.:|.|.|.:|||..::|.|||||.||:|:||||
Mouse  2074 SEGQTFQVAEFIVDTRNAGYGGLGLSIEGPSKVDINCEDMEDGTCKVTYCPTEPGTYIINIKFAD 2138

  Fly  2054 HHVEGSPFTVKVAGEGSNRKREKIQRERDAVPITEIGSQCKLTFKMPG----------------- 2101
            .||.||||||||.|||  |.:|.|.|.|.|..|..|||.|.|..|:||                 
Mouse  2139 KHVPGSPFTVKVTGEG--RMKESITRRRQAPSIATIGSTCDLNLKIPGNWFQMVSAQERLTRTFT 2201

  Fly  2102 ----------------------------------------------------------------- 2101
                                                                             
Mouse  2202 RSSHTYTRTERTEISKTRGGETKREVRVEESTQVGGDPFPAVFGDFLGRERLGSFGSITRQQEGE 2266

  Fly  2102 ITSFDLAACVTSPSNVTEDAEIQEVEDGLYAVHFVPKELGVHTVSVRYSEMHIPGSPFQFTVGPL 2166
            .:|.|:.|.|||||..||.|||.|.||..|:|.|||:|:|.|||:|:|...|:||||||||||||
Mouse  2267 ASSQDMTAQVTSPSGKTEAAEIVEGEDSAYSVRFVPQEMGPHTVTVKYRGQHVPGSPFQFTVGPL 2331

  Fly  2167 RDSGSHLVKAGGSGLERGVVGEAAEFNVWTREAGGGSLAISVEGPSKADIEFKDRKDGSCDVSYK 2231
            .:.|:|.|:|||:||||||.|..|||::||||||.|.|:|:|||||||:|.|:|||||||.|||.
Mouse  2332 GEGGAHKVRAGGTGLERGVAGVPAEFSIWTREAGAGGLSIAVEGPSKAEIAFEDRKDGSCGVSYV 2396

  Fly  2232 VTEPGEYRVGLKFNDRHIPDSPFKVYVSPDAGDAHKLEVQQFPQGNIQADAPYQFMVRKNGAKGE 2296
            |.|||:|.|.:||||.|||||||.|.|:..:.||.:|.|....:..::.:.|..|.|:.|||:|.
Mouse  2397 VQEPGDYEVSIKFNDEHIPDSPFVVPVASLSDDARRLTVTSLQETGLKVNQPASFAVQLNGARGV 2461

  Fly  2297 LDAKIVAPSGTDDDCFIQVIDGEMYSVRFYPRENGIHAIHVKFNGVHIPDSPFRIKVGK--DVAD 2359
            :||::..|||..::|::..:|.:.:::||.|.|||:|:|.|||||.|||.|||:|:||:  ...|
Mouse  2462 IDARVHTPSGAVEECYVSELDSDKHTIRFIPHENGVHSIDVKFNGAHIPGSPFKIRVGEQSQAGD 2526

  Fly  2360 PAAVHASGNGLDEVKTGHKADFIINTCNAGVGTLAVSIDGPSKVAMDCTEVEEGYKVRYTPLLPG 2424
            |..|.|.|.||:...||..::||:||.|||.|.|:|:|||||||.:||.|..||:.|.|||:.||
Mouse  2527 PGLVSAYGPGLEGGTTGVSSEFIVNTQNAGSGALSVTIDGPSKVQLDCRECPEGHVVTYTPMAPG 2591

  Fly  2425 EHYITVKYNN-MHIVGSPFKVNATGDKLA-DEGAQETSTVIVETVQKVAKGGKNTGVHLPTFKSD 2487
            .:.|.:||.. .||||||||...||.:|: .....|||||:||||.|.:.....:...:|.|.||
Mouse  2592 NYLIAIKYGGPQHIVGSPFKAKVTGPRLSGGHSLHETSTVLVETVTKSSSSRGASYSSIPKFSSD 2656

  Fly  2488 ASKVVSKGMGLKKAYIGKQNQFSISATDAGNNILYVGMYGPKGPCEEFHVKHAGHNNYNVQYLVR 2552
            |||||::|.||.:|::|::|.|::..:.||.|::.||::|||.||||.:|||.|:..|||.|.|:
Mouse  2657 ASKVVTRGPGLSQAFVGQKNSFTVDCSKAGTNMMMVGVHGPKTPCEEVYVKHMGNRVYNVTYTVK 2721

  Fly  2553 DRGQYVLLIKWGEEHIPGSPFQIDV 2577
            ::|.|:|::|||:|.:|||||:::|
Mouse  2722 EKGDYILIVKWGDESVPGSPFKVNV 2746

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cherNP_001262659.2 CH_dFLNA-like_rpt1 175..297 CDD:409160 88/122 (72%)
CH_dFLNA-like_rpt2 298..415 CDD:409164 76/116 (66%)
IG_FLMN 432..527 CDD:214720 52/94 (55%)
IG_FLMN 532..627 CDD:214720 40/115 (35%)
IG_FLMN 631..724 CDD:214720 44/92 (48%)
IG_FLMN 728..815 CDD:214720 53/88 (60%)
IG_FLMN 821..913 CDD:214720 38/91 (42%)
IG_FLMN 918..1001 CDD:214720 28/187 (15%)
Filamin 1012..1098 CDD:395505 29/88 (33%)
IG_FLMN 1109..1196 CDD:214720 59/86 (69%)
Filamin 1197..1293 CDD:395505 33/193 (17%)
IG_FLMN 1302..1392 CDD:214720 58/89 (65%)
IG_FLMN 1395..1490 CDD:214720 39/96 (41%)
IG_FLMN 1494..1587 CDD:214720 39/93 (42%)
IG_FLMN 1606..1682 CDD:214720 34/76 (45%)
IG_FLMN <1731..1791 CDD:214720 30/59 (51%)
IG_FLMN 1797..1884 CDD:214720 57/86 (66%)
IG_FLMN 1978..2067 CDD:214720 58/88 (66%)
Filamin <2111..2159 CDD:395505 29/47 (62%)
IG_FLMN 2172..2260 CDD:214720 62/87 (71%)
IG_FLMN 2265..2354 CDD:214720 37/88 (42%)
IG_FLMN 2360..2448 CDD:214720 47/88 (53%)
IG_FLMN 2488..2577 CDD:214720 45/88 (51%)
FlncXP_036008175.1 CH_FLNC_rpt1 23..147 CDD:409159 88/123 (72%)
CH_FLNC_rpt2 151..265 CDD:409163 76/115 (66%)
IG_FLMN 276..372 CDD:214720 52/95 (55%)
IG_FLMN 376..471 CDD:214720 39/94 (41%)
IG_FLMN 496..589 CDD:214720 44/92 (48%)
IG_FLMN 593..683 CDD:214720 53/89 (60%)
IG_FLMN 689..783 CDD:214720 40/93 (43%)
IG_FLMN 786..886 CDD:214720 23/99 (23%)
IG_FLMN 889..985 CDD:214720 10/95 (11%)
IG_FLMN 989..1082 CDD:214720 29/92 (32%)
IG_FLMN 1084..1173 CDD:214720 59/88 (67%)
IG_FLMN 1177..1269 CDD:214720 2/91 (2%)
IG_FLMN 1273..1369 CDD:214720 33/100 (33%)
IG_FLMN 1372..1461 CDD:214720 58/88 (66%)
IG_FLMN 1465..1558 CDD:214720 39/97 (40%)
IG_FLMN 1561..1655 CDD:214720 39/93 (42%)
IG_FLMN 1658..1754 CDD:214720 39/97 (40%)
IG_FLMN <1813..1877 CDD:214720 30/63 (48%)
IG_FLMN 1884..1970 CDD:214720 57/85 (67%)
IG_FLMN 2063..2152 CDD:214720 58/88 (66%)
IG_FLMN <2266..2330 CDD:214720 38/63 (60%)
IG_FLMN 2336..2424 CDD:214720 61/87 (70%)
Filamin 2429..2515 CDD:395505 36/85 (42%)
IG_FLMN 2527..2617 CDD:214720 48/89 (54%)
IG_FLMN 2657..2746 CDD:214720 45/88 (51%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 156 1.000 Domainoid score I4176
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1589 1.000 Inparanoid score I86
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG48636
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001288
OrthoInspector 1 1.000 - - otm43481
orthoMCL 1 0.900 - - OOG6_100805
Panther 1 1.100 - - O PTHR38537
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X791
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
109.970

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