DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cher and DST

DIOPT Version :10

Sequence 1:NP_001262659.2 Gene:cher / 42066 FlyBaseID:FBgn0014141 Length:2577 Species:Drosophila melanogaster
Sequence 2:NP_001361665.1 Gene:DST / 667 HGNCID:1090 Length:7818 Species:Homo sapiens


Alignment Length:1043 Identity:206/1043 - (19%)
Similarity:351/1043 - (33%) Gaps:367/1043 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    88 HYYNNSNSHGRKN--------APNSQQNQQNACVYTTSNSN-----NNNLEHNFSNLHFYAQQ-- 137
            |:.:...:..||.        .|....:.|.|.:...|:.|     :.:...:||:...::|:  
Human   103 HHQSEQETSVRKRRIKKSSRVQPEFYHSVQGASIRRPSSGNASYRCSMSSSADFSDEDDFSQKSG 167

  Fly   138 ---PAAHYDVCHQQTNDYYQPARQEGQQADQYEENFDEDMEAERDLAEDAQWKKIQQNTFTRWAN 199
               ||.      ..|..:..|..:..::..|.....|....|...:|::..  |:|:.|||:|.|
Human   168 SASPAP------GDTLPWNLPKHERSKRKIQGGSVLDPAERAVLRIADERD--KVQKKTFTKWIN 224

  Fly   200 EHLKTIDRSINNLETDLSDGLRLIALIEVLSQKRMPK---------------------------Y 237
            :||..:.:.:|:|..||.||..||:|:||||...:|:                           .
Human   225 QHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPRERDFLKTLRLVSATEACEYEQHEDVEDE 289

  Fly   238 NKRP----TFRSQKLENVSVALKFLQDEGIKIVNIDSSDIVDCKLKLILGLIWTLILHYSISMPM 298
            :|.|    ..|..:|:||.:||.:|:...:|:|||.:.||.|...||.||||||:|||:.||...
Human   290 DKGPREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIH 354

  Fly   299 WDGEDDKQLNGSGHTPKQRLLNWIHAK---IPDLPINNFTNDWTTGKAVGALVDACAPGLCPDWE 360
            ..||.:..      :.|:|||.|....   ...:...|||..|..||...|::....|.|. |..
Human   355 VTGESEDM------SAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLI-DMN 412

  Fly   361 LWDPKDAVQNASEAMGLADDWLNVRQLIKPEELVNPNVDEQSMMTYLSQYPNSKLKTGAPLRPKT 425
            ....:..:.|...|..:|:. :.|.:|:.||::...:.||:|::||:|...::.           
Human   413 TVAVQSNLANLEHAFYVAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAF----------- 465

  Fly   426 NPNSIPPPRVRAYGPGIEPIGPVVGAPANFTVETFSAGKGSVDVDIQGPNGEIEKADVRFNNDKN 490
                   |:|...|.||                      |:.||:::.         :.:.|..|
Human   466 -------PKVPEGGEGI----------------------GANDVEVKW---------IEYQNMVN 492

  Fly   491 LTYTVSYIPKSEGSHKVAVKFSGRDIPKSPFPVK-------------VEGHAGDASKVK------ 536
              |.:.:|     .|.|.. .|.|..|.:|..:|             :.....:.||:|      
Human   493 --YLIQWI-----RHHVTT-MSERTFPNNPVELKALYNQYLQFKETEIPPKETEKSKIKRLYKLL 549

  Fly   537 ---------VTGPGIQPNGVTIKKPTFFDILAKDAGRGVPEVIIIDPANHKTSVAAKVRQLE--- 589
                     ....|..||.:           .|:.|:     :||.....:.::..:|.:||   
Human   550 EIWIEFGRIKLLQGYHPNDI-----------EKEWGK-----LIIAMLEREKALRPEVERLEMLQ 598

  Fly   590 -------NDTWRCEYVTALQGLHSVNVFYAGTPIPNSPFPVKVAPLSDARKVRASGRGLQATGVR 647
                   .|:..||                                   .|:..:|..||:...|
Human   599 QIANRVQRDSVICE-----------------------------------DKLILAGNALQSDSKR 628

  Fly   648 VGDDADFKIYTEGAG---EGEPEVRVIGPGGMNQNV--MQSKVDGNTYECHYYPTKEGRYVIMVT 707
            :.....|:...|.||   |.|..:|        |:|  :|..:||..|:.....           
Human   629 LESGVQFQNEAEIAGYILECENLLR--------QHVIDVQILIDGKYYQADQLV----------- 674

  Fly   708 FAGQEVAKSPFEVKVGPKKESSIVAYGPGLSSGVIGYPAAFVVETNGETGALGFTVAGPSQAEIE 772
               |.|||...|:.....:.||:.:.|.              :.|..:|..:   ::|.:|:   
Human   675 ---QRVAKLRDEIMALRNECSSVYSKGR--------------ILTTEQTKLM---ISGITQS--- 716

  Fly   773 CHDNGDGSALVKYHPTAVGEYAVHILCDNEDIPKSPFIAQILPRTDFHPELVKASGPGLEKNGVT 837
             .::|                                .||.|     ||.|.         :|:|
Human   717 -LNSG--------------------------------FAQTL-----HPSLT---------SGLT 734

  Fly   838 INQPTSFTVDPSKAGNAPLDVVVQDVFGTKLPVELKNNPDGTKKVTYTPTSGVPHTVEVNYGGVS 902
            .:...|.|.....:|       :.....::|          |..||...|.|.|..:..|:....
Human   735 QSLTPSLTSSSMTSG-------LSSGMTSRL----------TPSVTPAYTPGFPSGLVPNFSSGV 782

  Fly   903 TPNSPHRVYVGVPVDAAKVQAFGPWLQPGVRPNAATHFNVDAREAGDA-----ELKVKIIHEETK 962
            .|||...:.:        :|...|.|:..:.....|...::.:...|.     |::|::...|..
Human   783 EPNSLQTLKL--------MQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWG 839

  Fly   963 IEVPC--RIIDNEDNTYSVEVIPPSKGAYTTTMTYGGQRVPLGEKVVVEQTVDVSKIKVDGLEPT 1025
            .::|.  ..::|..|.:                           :.:.|....:.:.|:..::.|
Human   840 SDLPSVESHLENHKNVH---------------------------RAIEEFESSLKEAKISEIQMT 877

  Fly  1026 APL 1028
            |||
Human   878 APL 880

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cherNP_001262659.2 CH_dFLNA-like_rpt1 175..297 CDD:409160 54/152 (36%)
CH_dFLNA-like_rpt2 298..415 CDD:409164 30/119 (25%)
IG_FLMN 432..527 CDD:214720 19/107 (18%)
IG_FLMN 532..627 CDD:214720 16/119 (13%)
IG_FLMN 631..724 CDD:214720 23/97 (24%)
IG_FLMN 728..815 CDD:214720 10/86 (12%)
IG_FLMN 821..913 CDD:214720 18/91 (20%)
IG_FLMN 918..1001 CDD:214720 11/89 (12%)
Filamin 1012..1098 CDD:395505 5/17 (29%)
IG_FLMN 1109..1196 CDD:214720
Filamin 1197..1293 CDD:395505
IG_FLMN 1302..1392 CDD:214720
IG_FLMN 1395..1490 CDD:214720
IG_FLMN 1494..1587 CDD:214720
IG_FLMN 1606..1682 CDD:214720
IG_FLMN <1731..1791 CDD:214720
IG_FLMN 1797..1884 CDD:214720
IG_FLMN 1978..2067 CDD:214720
Filamin <2111..2159 CDD:395505
IG_FLMN 2172..2260 CDD:214720
IG_FLMN 2265..2354 CDD:214720
IG_FLMN 2360..2448 CDD:214720
IG_FLMN 2488..2577 CDD:214720
DSTNP_001361665.1 CH_SF 201..358 CDD:469584 54/158 (34%)
CH_DYST_rpt2 363..466 CDD:409088 28/122 (23%)
SPEC 819..910 CDD:197544 13/89 (15%)
SPEC 912..1094 CDD:238103
SH3_10 1087..1153 CDD:407754
Spectrin_like 1188..1265 CDD:465730
SCP-1 <1205..1480 CDD:114219
SPEC 1405..1569 CDD:413338
PLEC 1763..1794 CDD:197605
Plectin 1872..1909 CDD:459901
Plectin 1986..2024 CDD:459901
Plectin 2062..2100 CDD:459901
SCP-1 3445..4110 CDD:114219
SMC_prok_B <3824..4606 CDD:274008
SPEC 4135..4364 CDD:238103
SPEC 4725..4946 CDD:238103
SPEC 4951..5165 CDD:238103
SPEC 5167..5378 CDD:238103
SPEC 5493..5708 CDD:238103
SPEC 5607..5820 CDD:238103
SPEC 5714..5929 CDD:238103
SPEC 5931..6146 CDD:238103
SPEC 6042..6255 CDD:238103
SPEC 6152..6368 CDD:238103
SPEC 6370..6587 CDD:238103
SPEC 6482..6696 CDD:238103
SPEC 6590..6805 CDD:238103
SPEC 6698..6914 CDD:238103
SPEC 6916..7132 CDD:238103
SPEC 7029..7241 CDD:238103
FRQ1 <7412..7475 CDD:444056
GAS2 7487..7562 CDD:128539
Blue background indicates that the domain is not in the aligned region.

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