DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cher and flncb

DIOPT Version :9

Sequence 1:NP_001262659.2 Gene:cher / 42066 FlyBaseID:FBgn0014141 Length:2577 Species:Drosophila melanogaster
Sequence 2:XP_009298480.1 Gene:flncb / 570288 ZFINID:ZDB-GENE-041008-175 Length:2773 Species:Danio rerio


Alignment Length:2818 Identity:1258/2818 - (44%)
Similarity:1657/2818 - (58%) Gaps:417/2818 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   129 SNLHFYAQQ-PAAHYDVCHQQTNDYYQPARQEGQQADQYEENFDEDMEA-ERDLAEDAQWKKIQQ 191
            ||..:|.|| |..:|                  |..|..|:. ||:|.| |:||||||.||||||
Zfish     3 SNNTYYDQQLPPQYY------------------QGTDNGEDG-DEEMPATEKDLAEDAPWKKIQQ 48

  Fly   192 NTFTRWANEHLKTIDRSINNLETDLSDGLRLIALIEVLSQKRM-PKYNKRPTFRSQKLENVSVAL 255
            ||||||.|||||.::|.|.:|:.||:|||:||.|:||||||:| .||:.||.||..|||||||||
Zfish    49 NTFTRWCNEHLKCLNRKILDLQKDLTDGLKLIGLLEVLSQKKMYRKYHARPNFRQMKLENVSVAL 113

  Fly   256 KFLQDEGIKIVNIDSSDIVDCKLKLILGLIWTLILHYSISMPMWDGEDDKQLNGSGHTPKQRLLN 320
            :||:.|.||:|:|||..|||..||||||||||||||||||||||:.|||:  :....|||||||.
Zfish   114 EFLEREHIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWEDEDDE--DARKLTPKQRLLG 176

  Fly   321 WIHAKIPDLPINNFTNDWTTGKAVGALVDACAPGLCPDWELWDPKDAVQNASEAMGLADDWLNVR 385
            ||..|:|.|.||||..||..|||:|||||.||||||||||.|||...|:||.|||..|||||.|.
Zfish   177 WIQNKVPQLHINNFHRDWRDGKALGALVDNCAPGLCPDWETWDPSQPVENAREAMQQADDWLGVP 241

  Fly   386 QLIKPEELVNPNVDEQSMMTYLSQYPNSKLKTGAPLRPKTNPNSIPPPRVRAYGPGIEPIGPVVG 450
            |:|.|||:|:|||||.|:||||||:|.:|||.||||||||    :.|.|.:||||||||.|.||.
Zfish   242 QVIAPEEIVDPNVDEHSVMTYLSQFPKAKLKPGAPLRPKT----LHPKRAKAYGPGIEPRGNVVL 302

  Fly   451 APANFTVETFSAGKGSVDVDIQGPNGEIEKADVRFNNDKNLTYTVSYIPKSEGSHKVAVKFSGRD 515
            .||.|.|||..||.|.|.|.|:.|.|..|:|.|..|||:|.:|:|.|:||.||.|||.|.|:|:|
Zfish   303 KPAEFVVETVEAGLGEVLVYIEDPEGHTEEARVIPNNDRNRSYSVVYVPKVEGLHKVKVLFAGQD 367

  Fly   516 IPKSPFPVKVEGHAGDASKVKVTGPGIQPNGVTIKKPTFFDILAKDAGRGVPEVIIIDPANHKTS 580
            |.:|||.|.|....||.:||:..|||::|.|....|||:|||....||.|...|||:|....:.:
Zfish   368 IDRSPFLVNVSKALGDPNKVQARGPGLEPVGNVANKPTYFDIYTAGAGAGDVGVIIVDSQGRRDT 432

  Fly   581 VAAKVRQLENDTWRCEYVTALQGLHSVNVFYAGTPIPNSPF----------------PVKVAPLS 629
            |...:....:..:||.|...|:|.|::.|.:||..||.|||                ||.:.|.|
Zfish   433 VEIILENKGDSVFRCTYGPILEGPHTIYVTFAGQQIPRSPFTVHISEAPPHGRQIGSPVHIIPQS 497

  Fly   630 -------DARKV------------------RASGRGLQATGVRVGDDADFKIYTEGAGEGEPEVR 669
                   .|:||                  ||.|||||..||||.:.||||:||:|||.||..|.
Zfish   498 LRTPPSEKAKKVPPPTPPKPRRPTSNPNACRAIGRGLQPKGVRVKEVADFKVYTKGAGSGELRVH 562

  Fly   670 VIGPGGMNQNVMQSKVDGNTYECHYYPTKEGRYVIMVTFAGQEVAKSPFEVKV----GPKKESSI 730
            |.||.|.::.|....:....|||.|||...|:|:|.||:.|..:.:|||||.:    ||:|   :
Zfish   563 VKGPTGGDEPVKVEDLGDGVYECDYYPIFCGKYIITVTWGGHAIPRSPFEVIISEDAGPQK---V 624

  Fly   731 VAYGPGLSSGVIGYPAAFVVETNG-ETGALGFTVAGPSQAEIECHDNGDGSALVKYHPTAVGEYA 794
            .|:||||.:|::|..|.||||..| |.|.|||::.|||||:|||.|.||||..|.|.||..|:||
Zfish   625 RAWGPGLETGMVGKSADFVVEAIGTEVGTLGFSIEGPSQAKIECDDKGDGSCDVLYWPTEPGDYA 689

  Fly   795 VHILCDNEDIPKSPFIAQILP-RTDFHPELVKASGPGLEKNGVTINQPTSFTVDPSKAGNAPLDV 858
            ||::||:|||..|||:|.||| .:|..||.||..|||||..|..:|:|..||:|...||...|.:
Zfish   690 VHVICDDEDIKDSPFMAHILPAASDVFPEKVKCYGPGLEPTGCIVNKPAEFTIDARGAGRGQLQI 754

  Fly   859 VVQDVFGTKLPVELKNNPDGTKKVTYTPTSGVPHTVEVNYGGVSTPNSPHRVYVGVPVDAAKVQA 923
            ..||..|..:.:::.:|.|.|....|.|...:.||:.:.:|.|:.||||.||.:|.......|:.
Zfish   755 YAQDSEGFPINIQITDNGDSTYFCVYIPIKPIKHTIIITWGEVNVPNSPFRVTIGEGSHPENVKV 819

  Fly   924 FGPWLQ-PGVRPNAATHFNVDAREAGDAELKVKI-----IHEETKIEVPCRIIDNEDNTYSVEVI 982
            .||.:: .|::.|..|:|.||..|||..::.:.|     :....:.::...||.|:::|::|:..
Zfish   820 HGPGVEKTGLKANEPTYFTVDCSEAGQGDVSIGIKCAPGVVGPAEADIDFDIIKNDNDTFTVKYT 884

  Fly   983 PPSKGAYTTTMTYGGQRVPLGE-KVVVEQTVDVSKIKVD-------GLEPTAPLN---------- 1029
            ||..|.||..:.:..|.:|:.. ::.|:.:.|.:|:|.:       |:|...|.:          
Zfish   885 PPGAGRYTIMVLFADQEIPISPFRIKVDPSHDANKVKAEGPGLNKTGVEVGKPTHFTIYTKGAGK 949

  Fly  1030 ----------------------------------SLQQFRI---ITHG---LPKADLAVTITSPS 1054
                                              :|||..:   :.||   :||:...:::..|.
Zfish   950 ATPEVHFTASGRGDAVSDFEIIDNHDYSFTVRYTALQQGNMTISVCHGGDPIPKSPFTISVAPPL 1014

  Fly  1055 G-NRIKAH------IIPTAEGFLVN--------------------------------------FT 1074
            . |::|.|      .:...|.|.||                                      :.
Zfish  1015 DLNKVKVHGLNNKVDVGKDEEFTVNTRGAGGQGKVDVKITSPSRRPIPCKVESGASNEVHTVKYI 1079

  Fly  1075 PTQLGEYLLSICFGGTPITPRPFRLQCLTGSDSNKVQAFGPGLERGIVGQPAEFMIDTRGAGQGG 1139
            |.:.|.|.:.|.:.|.|:...||.::.:...|.:||:|:||||:.||||:||.|.|||:|||.||
Zfish  1080 PPEEGPYKVDISYDGNPVPGSPFTVEGVMPPDPSKVRAYGPGLKGGIVGKPAPFAIDTKGAGTGG 1144

  Fly  1140 LGVTVEGPCEAAINCRDNGDGTCNVAYLPTEAGDYTVNITFNERHITGSPFQPLIVPV------- 1197
            ||:||||||||.|.|:|||||:|:|:|||||.|:|::||.|.:.||.||||:.::..|       
Zfish  1145 LGLTVEGPCEAKIECQDNGDGSCSVSYLPTEPGEYSINILFADAHIPGSPFKAMVQSVFDPSKVT 1209

  Fly  1198 ---PNLKNTRV------------------------------------------------------ 1205
               |.|:..:|                                                      
Zfish  1210 ASGPGLERGKVNEAGSFTVDCSKAGEAELTIEIISDSGAQAEVHVQNNSDGTYSITYIPPFHGMY 1274

  Fly  1206 --------------------------SGI-----GIQPHGVIMNAATDFMVDMSKVGSNIDSGKL 1239
                                      |||     |::|.||:....|.|:|| ::|.:.:....:
Zfish  1275 TITIKYGGHAVPKFPARVQVDPALDTSGIKVYGPGVEPRGVLREVTTHFIVD-TRVHNKMGGNHI 1338

  Fly  1240 SCAIFDPMGHVLPSKIVQGPTDDIFRIMYTPFEAGRHTIELMYDNIPVPGSPFVVNVKSGCDPAR 1304
            ...|.:|.| ......|....|..:|:.||.:|.|.|.||::||::|||.|||.|.|..||||:|
Zfish  1339 KVRIVNPSG-ANTDAYVTDKADGTYRVEYTAYEDGVHLIEVLYDDVPVPKSPFRVAVAEGCDPSR 1402

  Fly  1305 CKAYGPGLEKGLTNQKNKFTVETKGAGNGGLSLAIEGPSEAKMTCTDNRDGSCDVDYLATDPGEY 1369
            .:|||||||:||.|:.|:|||||:|||.|||.|||||||||||:|.||:||||.|:|:...||||
Zfish  1403 VRAYGPGLEEGLVNKPNRFTVETRGAGTGGLGLAIEGPSEAKMSCKDNKDGSCSVEYIPFTPGEY 1467

  Fly  1370 DITIRFADKHIPGSPFRVLVEETVDPSKVKVYGPGIEHGQVRESVPTFFNVDVGEAGPGRIAVKL 1434
            |:.|.|....||||||||.|.|.|||||||..|||:..| ||..||..|.||..:||...:.|.|
Zfish  1468 DVNITFGGLPIPGSPFRVPVRELVDPSKVKCTGPGLGSG-VRAHVPQTFTVDCSKAGLAPLEVLL 1531

  Fly  1435 TNSEGIPVDNLRVEDKGNCIYAVHYVPPKAGSVLTCQVKFSEVEVPCSPFVMTVFPKSEPTKVKV 1499
            ....|: .:.:.:.|.|:..:.|.|.|.|.|....| ||:::.|||.|||.:.|.|..:.:||:.
Zfish  1532 YGPTGM-TEPVNITDNGDGTHTVVYTPAKDGPYTVC-VKYADQEVPRSPFKIKVLPAHDASKVRA 1594

  Fly  1500 KGVN-EKKKTPASLPAEFEIDTKQAGQADINVAIKNPKGKAMQPRLEEVSTGTYVVSFVPDECGT 1563
            .|.. .....|||||.||.||.:.||:..:.|.|.:|:||..:..:.:...|||.||:|||..|.
Zfish  1595 SGPGLNASGVPASLPVEFTIDARDAGEGLLTVQILDPEGKPKKANIRDNRDGTYTVSYVPDMTGR 1659

  Fly  1564 YQCSIKYGDKEIEGSPFKLEAFPTGEAKKCKLVEQ----------APKIQTSGSQSHLKVDAREA 1618
            |..:||||..||..||:::.|.|:|:|.||.:...          .|.||. |.::.:.|||:.|
Zfish  1660 YTITIKYGGDEIPYSPYRIHALPSGDASKCLVTVSIGGHGLGSGLGPTIQI-GEETVITVDAKAA 1723

  Fly  1619 GDGAVTCKITNKAGSEIVDIDVIEK-DGFFDILYALNDPGDYDINVKFGGKDIPNGSFSIKAVES 1682
            |.|.||||::...|:|: |:||:|. ||.|||.|...:||.|.|.::|||:.|||..|.:.|.::
Zfish  1724 GKGKVTCKVSTPDGAEL-DVDVVENADGTFDIYYTAPEPGKYVITIRFGGEHIPNSPFHVVASDT 1787

  Fly  1683 IEQYSHSEYIEEHTTKVVQQTT----QSELVNGKSEITYRSVAFEK---------LPLPTTGGNV 1734
            |      ..|||...|:..|..    |....:..:|....:|...:         :|.....|.:
Zfish  1788 I------PIIEEPCDKLQLQQPYAPYQGYSPHWATEEPVTAVDIIEPVLRPFNLVIPFTVQKGEI 1846

  Fly  1735 TAEVRMPSGKVDKPVIQDNRDGTVSVKYDPREEGSHELVVKYNGEPVQGSPFKFHVDSITSGYVT 1799
            |.||.|||||...|.|.||:||||:|||.|.|:|.||:.:||:|..:.|||.:|:||:|.||:|.
Zfish  1847 TGEVHMPSGKTASPHITDNKDGTVTVKYAPTEKGLHEMDIKYDGNHIPGSPLQFYVDAINSGHVN 1911

  Fly  1800 AYGPGLTHGVTGEPANFTISTKGASAGGLTMAVEGPSKADINYHDNKDGTVSVQYLPTAPGEYQV 1864
            ||||||:||:..:.|.|||.||.|..|||::||||||||:|:..||||||.:|.|||||||:|.:
Zfish  1912 AYGPGLSHGMVNKSATFTIVTKDAGEGGLSLAVEGPSKAEISCKDNKDGTCTVSYLPTAPGDYNI 1976

  Fly  1865 SVRFGDKHIKGSPYFAKITGEGRKR-NQISVGSCSEVTMPGDITDDDLRALNASIQAPSGLEEPC 1928
            .|:|.||||.|||:.|||||:...| :|::||:.::|::  .||:.||.:|:|:|:||||.||||
Zfish  1977 IVKFDDKHIAGSPFTAKITGDDSMRTSQLNVGTATDVSL--KITETDLSSLSATIRAPSGNEEPC 2039

  Fly  1929 FLKRMPTGNIGISFTPREIGEHLVSVKRLGKHINNSPFKVTVCEREVGDAKKVKVSGTGLKEGQT 1993
            .|||:|..:|||||||:|:|||:||||:.|||:.|||||:.|.:.|:|||.||||||.||.||.|
Zfish  2040 LLKRLPNRHIGISFTPKEVGEHVVSVKKNGKHVTNSPFKIMVGQSEIGDASKVKVSGKGLIEGHT 2104

  Fly  1994 HADNIFSVDTRNAGFGGLSVSIEGPSKAEIQCTDKDDGTLNISYKPTEPGYYIVNLKFADHHVEG 2058
            .....|.||||:||:|||.:|||||||.:|.|:|.||||..::|.|||||.||:|:||||.||.|
Zfish  2105 FEVAEFIVDTRSAGYGGLGLSIEGPSKVDINCSDVDDGTCKVTYCPTEPGTYIINIKFADQHVPG 2169

  Fly  2059 SPFTVKVAGEGSNRKREKIQRERDAVPITEIGSQCKLTFKMPG-----------IT--------- 2103
            |||||||.|||  |.:|.|.|:|.|..|..:||.|.|..|:||           :|         
Zfish  2170 SPFTVKVLGEG--RMKESITRKRQAPSIATVGSTCDLNLKIPGNWFQMVSAQERLTRTFTRSSHT 2232

  Fly  2104 ---------------------------------------------------------------SF 2105
                                                                           :.
Zfish  2233 YTRTERTEISKTRAGETKREVRVEESTQVGGDPFRDVFGGFMGRESLGPFNSPQGRQSEGESGTQ 2297

  Fly  2106 DLAACVTSPSNVTEDAEIQEVEDGLYAVHFVPKELGVHTVSVRYSEMHIPGSPFQFTVGPLRDSG 2170
            ::.|.|||||..||||||.|.||..|:|.|||.|:|.|||:|:|...|:||||||||||||.:.|
Zfish  2298 EMTAQVTSPSGNTEDAEIIEGEDSTYSVRFVPHEMGPHTVNVKYRGQHVPGSPFQFTVGPLGEGG 2362

  Fly  2171 SHLVKAGGSGLERGVVGEAAEFNVWTREAGGGSLAISVEGPSKADIEFKDRKDGSCDVSYKVTEP 2235
            :|.|:|||:||:|||.|..|||::||||||.|.|:|:|||||||:|.|:|||||||.|:|.|.||
Zfish  2363 AHKVRAGGTGLDRGVAGVPAEFSIWTREAGAGGLSIAVEGPSKAEISFEDRKDGSCGVAYIVQEP 2427

  Fly  2236 GEYRVGLKFNDRHIPDSPFKVYVSPDAGDAHKLEVQQFPQGNIQADAPYQFMVRKNGAKGELDAK 2300
            |:|.|.:||||.|||||||.|.::..:.||..|.|....:..::.:....|.|:.|||:|.:|||
Zfish  2428 GDYEVSIKFNDEHIPDSPFIVPIASLSDDARLLTVTSLQEMGLKVNQEASFAVQLNGARGAIDAK 2492

  Fly  2301 IVAPSGTDDDCFIQVIDGEMYSVRFYPRENGIHAIHVKFNGVHIPDSPFRIKVGK--DVADPAAV 2363
            :..|||..::|:|..:|.:.:::||.|||||:|:|.|:|||.|||.|||:|:||:  ...||..|
Zfish  2493 VHTPSGAVEECYITELDNDKHAIRFIPRENGVHSIDVRFNGSHIPGSPFKIRVGEPGQAGDPGMV 2557

  Fly  2364 HASGNGLDEVKTGHKADFIINTCNAGVGTLAVSIDGPSKVAMDCTEVEEGYKVRYTPLLPGEHYI 2428
            .|.|.||:...||..:|||:||||||.|.|:|:|||||||.|||.|..|||||.|||:.||.:.|
Zfish  2558 TAFGPGLEGGTTGVPSDFIVNTCNAGSGALSVTIDGPSKVKMDCQECPEGYKVTYTPMAPGSYLI 2622

  Fly  2429 TVKYNN-MHIVGSPFKVNATGDKLA-DEGAQETSTVIVETVQKVAK--GGKNTGVHLPTFKSDAS 2489
            ::||.. .||||||||...:|.:|: .....|||:|:||||.|.:.  |..:|   ||.|.||||
Zfish  2623 SIKYGGPQHIVGSPFKAKVSGARLSGGHSLHETSSVLVETVTKSSSVAGSFST---LPKFSSDAS 2684

  Fly  2490 KVVSKGMGLKKAYIGKQNQFSISATDAGNNILYVGMYGPKGPCEEFHVKHAGHNNYNVQYLVRDR 2554
            ||||:|.||.||:||::|.|::..:.||.|:|.||::|||.||||.:|||.|:..|||.|.|:::
Zfish  2685 KVVSRGAGLSKAFIGQKNTFTVDCSKAGTNMLMVGVHGPKTPCEEVYVKHMGNRMYNVTYTVKEK 2749

  Fly  2555 GQYVLLIKWGEEHIPGSPFQIDV 2577
            |.|:|::|||||.:|||||.:.|
Zfish  2750 GDYILIVKWGEEMVPGSPFHVTV 2772

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cherNP_001262659.2 CH_dFLNA-like_rpt1 175..297 CDD:409160 88/123 (72%)
CH_dFLNA-like_rpt2 298..415 CDD:409164 75/116 (65%)
IG_FLMN 432..527 CDD:214720 54/94 (57%)
IG_FLMN 532..627 CDD:214720 37/110 (34%)
IG_FLMN 631..724 CDD:214720 48/114 (42%)
IG_FLMN 728..815 CDD:214720 50/87 (57%)
IG_FLMN 821..913 CDD:214720 36/91 (40%)
IG_FLMN 918..1001 CDD:214720 24/88 (27%)
Filamin 1012..1098 CDD:395505 28/187 (15%)
IG_FLMN 1109..1196 CDD:214720 57/86 (66%)
Filamin 1197..1293 CDD:395505 36/190 (19%)
IG_FLMN 1302..1392 CDD:214720 60/89 (67%)
IG_FLMN 1395..1490 CDD:214720 38/94 (40%)
IG_FLMN 1494..1587 CDD:214720 38/93 (41%)
IG_FLMN 1606..1682 CDD:214720 35/76 (46%)
IG_FLMN <1731..1791 CDD:214720 32/59 (54%)
IG_FLMN 1797..1884 CDD:214720 55/86 (64%)
IG_FLMN 1978..2067 CDD:214720 59/88 (67%)
Filamin <2111..2159 CDD:395505 30/47 (64%)
IG_FLMN 2172..2260 CDD:214720 59/87 (68%)
IG_FLMN 2265..2354 CDD:214720 38/88 (43%)
IG_FLMN 2360..2448 CDD:214720 52/88 (59%)
IG_FLMN 2488..2577 CDD:214720 50/88 (57%)
flncbXP_009298480.1 SAC6 43..>269 CDD:227401 157/227 (69%)
IG_FLMN 284..380 CDD:214720 54/95 (57%)
IG_FLMN 384..480 CDD:214720 35/95 (37%)
IG_FLMN 524..617 CDD:214720 45/92 (49%)
IG_FLMN 621..711 CDD:214720 53/92 (58%)
IG_FLMN 717..811 CDD:214720 37/93 (40%)
IG_FLMN 814..914 CDD:214720 26/99 (26%)
IG_FLMN 917..1013 CDD:214720 12/95 (13%)
IG_FLMN 1018..1105 CDD:214720 14/86 (16%)
IG_FLMN 1112..1199 CDD:214720 57/86 (66%)
IG_FLMN 1205..1297 CDD:214720 3/91 (3%)
IG_FLMN 1301..1397 CDD:214720 35/97 (36%)
IG_FLMN 1400..1487 CDD:214720 59/86 (69%)
IG_FLMN 1493..1586 CDD:214720 38/95 (40%)
IG_FLMN 1589..1683 CDD:214720 38/93 (41%)
IG_FLMN 1709..1787 CDD:214720 36/79 (46%)
IG_FLMN <1839..1903 CDD:214720 32/63 (51%)
IG_FLMN 1910..1996 CDD:214720 55/85 (65%)
IG_FLMN 2089..2178 CDD:214720 59/88 (67%)
IG_FLMN <2295..2357 CDD:214720 37/61 (61%)
IG_FLMN 2363..2451 CDD:214720 59/87 (68%)
IG_FLMN 2471..2548 CDD:214720 37/76 (49%)
IG_FLMN 2554..2644 CDD:214720 52/89 (58%)
IG_FLMN 2683..2772 CDD:214720 50/88 (57%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 158 1.000 Domainoid score I4073
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1539 1.000 Inparanoid score I95
OMA 1 1.010 - - QHG48636
OrthoDB 1 1.010 - - D24684at33208
OrthoFinder 1 1.000 - - FOG0001288
OrthoInspector 1 1.000 - - otm24394
orthoMCL 1 0.900 - - OOG6_100805
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3976
SonicParanoid 1 1.000 - - X791
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
1110.910

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