Protein Alignment cher and flnbb

DIOPT Version :10

• Sequence 1: NP_001262659.2
• Gene: cher / 42066
• FlyBaseID: FBgn0014141
• Length: 2577
• Species: Drosophila melanogaster
• Sequence 2: XP_021325608.1
• Gene: flnbb / 563023
• ZFINID: ZDB-GENE-041026-1
• Length: 2233
• Species: Danio rerio
• Alignment Length: 2676
• Identity: 801/2676 - (29%)
• Similarity: 1175/2676 - (43%)
• Gaps: 734/2676 - (27%)

  Fly   179 DLAEDAQWKKIQQNTFTRWANEHLKTIDRSINNLETDLSDGLRLIALIEVLSQKRM-PKYNKRPT 242
            :||:||.|||||:||||||.||||::::..|::|:|||||||.||:|:||||.||| .||:.|||
Zfish    14 NLADDAPWKKIQKNTFTRWCNEHLRSVNMRISDLKTDLSDGLVLISLLEVLSHKRMFRKYHTRPT 78

  Fly   243 FRSQKLENVSVALKFLQDEGIKIVNIDSSDIVDCKLKLILGLIWTLILHYSISMPMWDGEDDKQL 307
            ||..||:||||||:||..|.:|:|:|||..|||..|||||||:||||.|||||.|:|  ||:...
Zfish    79 FRQLKLDNVSVALEFLDHEKVKLVSIDSKAIVDGNLKLILGLVWTLIQHYSISTPVW--EDEAND 141

  Fly   308 NGSGHTPKQRLLNWIHAKIPDLPINNFTNDWTTGKAVGALVDACAPGLCPDWELWDPKDAVQNAS 372
            :.|..||:.|||.||..|:|:|||.||:.||..|||:|||||..|||||||||.||....|.|..
Zfish   142 SVSKLTPEMRLLGWIQNKVPELPITNFSQDWQDGKALGALVDGLAPGLCPDWESWDSVHRVSNTK 206

  Fly   373 EAMGLADDWLNVRQLIKPEELVNPNVDEQSMMTYLSQYPNSKLKTGAPLRPKTNPNSIPPPRVRA 437
            |||..|||||.|.|||.|||:::|.|||||:|||||.:|.::||.||||:||    .:|.|:.
Zfish   207 EAMQQADDWLGVPQLIAPEEILDPAVDEQSVMTYLSLFPKARLKPGAPLKPK----KVPKPKA-- 265

  Fly   438 YGPGIEPIGPVVGAPANFTVETFSAGKGSVDVDIQGPNGEIEKADVRFNNDKNLTYTVSYIPKSE 502
                                                                             
Zfish   266 ----------------------------------------------------------------- 265

  Fly   503 GSHKVAVKFSGRDIPKSPFPVKVEGHAGDASKVKVTGPGIQPNGVTIKKPTFFDILAKDAGRGVP 567
                                                                             
Zfish   266 ----------------------------------------------------------------- 265

  Fly   568 EVIIIDPANHKTSVAAKVRQLENDTWRCEYVTALQGLHSVNVFYAGTPIPNSPFPVKVAPLSDAR 632
                                       |
Zfish   266 ---------------------------C------------------------------------- 266

  Fly   633 KVRASGRGLQATGVRVGDDADFKIYTEGAGEGEPEVRVIGPGGMNQNVMQSKVDGNTYECHYYPT 697
              ||:|||||:.|:||...|:||:.|..||.|..:|.:..|.|...:|.|.::....:...|.|:
Zfish   267 --RATGRGLQSKGIRVEQLAEFKVDTCRAGPGNLDVHIRDPSGSEVSVTQKELFKGVFGFQYTPS 329

  Fly   698 KEGRYVIMVTFAGQEVAKSPFEVKVGPKK-ESSIVAYGPGLSSGVIGYPAAFVVETNG-ETGALG 760
            .||.:.:.:|:.||.::||||:|.|||:. ...|..:||||..|.:|.||.|:||:.| ::|.||
Zfish   330 AEGDHTVDITWVGQHISKSPFKVNVGPEAGPQKIRVWGPGLEGGTVGSPAQFMVESVGADSGMLG 394

  Fly   761 FTVAGPSQAEIECHDNGDGSALVKYHPTAVGEYAVHILCDNEDIPKSPFIAQILPRT-DFHPELV 824
            |.:.|||||:|.|.|:.|||..|::.||..||||||::||:|:|..|||:|.|.|:: .|||:.|
Zfish   395 FAIEGPSQAKIACDDHNDGSCQVRFWPTEAGEYAVHVMCDDEEIQDSPFMASIRPKSKGFHPDKV 459

  Fly   825 KASGPGLEKNGVTINQPTSFTVDPSKAGNAPLDVVVQDVFGTKLPVELKNNPDGTKKVTYTPTSG 889
            |..|||:.:.|..||....|.||..:||...|.|..|...|..:.|.:.:...|....:|||:|.
Zfish   460 KVEGPGVSQTGCVINLQNEFIVDTRQAGEGELAVFAQRADGECVDVTISSEQSGVFVCSYTPSSL 524

  Fly   890 VPHTVEVNYGGVSTPNS---------------------------------PHRVYVG-------- 913
            ..||:.|.:|||..|.|                                 |..|:.|
Zfish   525 SKHTIAVTWGGVMVPGSPFIVTPRRIKITPCSPVWFKPDGSEICYSDEDFPENVHPGGRGELVMN 589

  Fly   914 ------VPVDAAKVQAFGPWLQPGVRPNAATHFNVDAREAGDAELKVKIIHEETKIEVPCRIIDN 972
                  :|.||.||.|.||.|..||....| .|.:|...||...|.|::   :...||..:.:|:
Zfish   590 VISPSNMPADATKVNAHGPGLTEGVVGEQA-EFIIDTSRAGSGRLDVRV---DGPSEVTLQCLDD 650

  Fly   973 EDNTYSVEVIPPSKGAYTTTMTYGGQRV---PLGEKVVVEQTVDVSKIKVDGLEPTAPLNSLQQF 1034
            :|.|.:|..:|...|.|...:.:....:   |.|..  :...||.||:.|        .||..|.
Zfish   651 QDGTCTVLYLPTEHGMYQINVLFDNSHIPGSPFGAN--IHHPVDPSKVLV--------TNSALQH 705

  Fly  1035 RIITHGLP-----------KADLAVTITSPSGNRIKAHIIPTAEG-FLVNFTPTQLGEYLLSICF 1087
            .|:  |.|           ..||:|...|.||..::..:....:| :.|.:.|...|.|.|.:.:
Zfish   706 GIV--GEPCIVNIDCAKVGSEDLSVQAISDSGVVVETEVKENEDGTYTVVYVPRTGGVYTLLLKY 768

  Fly  1088 GGTPITPRPFRLQ---------------CLTG---SDSNKVQAFGPGLERGIVGQPAEFMIDTRG 1134
            ||..:......::               .:.|   :|:::|.|.|.||::|::|.|..|.::||
Zfish   769 GGKVLPVHKVMVEQKVYKSHVKVSRRGGVVVGERETDASQVVASGLGLQKGLIGHPNMFCVNTR- 832

  Fly  1135 AGQGGLGVTVEGPCEAAINCRDNGDGTCNVAYLPTEAGDYTVNITFNERHITGSPFQPLIVPVPN 1199
            :....||||||||.:..:.|:|.|.|...|.|.||..|:|.::||..|..|.||||   :|.|.:
Zfish   833 SPVDDLGVTVEGPSDCQVTCKDGGQGVYGVEYTPTVPGEYKISITSGENSIPGSPF---VVSVDD 894

  Fly  1200 LKNTRVSGIGIQPHGVIM--NAATDFMVDMSKVGSNIDSGKLSCAIFDPMGHVLPSKIVQGPTDD 1262
            :.||..||..:|. |:.:  ||.|...: :...||.:.....:..:.|....:.|..:....:.:
Zfish   895 VSNTAGSGDCLQA-GICISSNAVTSQEI-VKHNGSRMHRASPASLVKDRKPVLDPQSLYGSSSPN 957

  Fly  1263 IFRIMYTPFEAGRHTIELMYD----NIPVPGSPFVVNVKSGCDPARCKAYGPGLEKGLTNQKNKF 1323
            .|:.:  |.......:.|.:|    :|..||      :|.|.    |         |.|.|  .|
Zfish   958 QFQAL--PKYGRDKELSLAHDLNMADIIAPG------IKGGI----C---------GKTPQ--GF 999

  Fly  1324 TVETKGAGNGGLSLAIEGPSEAK--MTCTDNRDGSCDVDYLATDPGEYDITIRFADKHIPGSPFR 1386
            |:....:|....::|:..|..:|  :..||||||||...||.|..|.:.:.::|.::......|:
Zfish  1000 TISCSSSGESPNAVAVVRPDGSKEFLELTDNRDGSCSGVYLPTMDGCHSLIVKFPNEESFNRQFQ 1064

  Fly  1387 VLVEETVDPSKVKVYGPGIEHGQVRESVPTFFNVDVGEAGPGRIAVKLTNSEGIPVDNLRVEDKG 1451
            ||  .|.:.::|.|.|||:..|...:...||. :|...:......|.:....||. :.:.|.|.|
Zfish  1065 VL--PTDELAEVNVSGPGLTSGMCAQCPQTFI-IDCTSSRKTLQFVTMMTPNGIS-EIMEVRDNG 1125

  Fly  1452 NCIYAVHYVPPKAGSVLTCQVKFSEVEVPCSPFVMTVFPKSEPTKVKVKGVNEK-KKTP------ 1509
            :|.|:|:|.|...| :.:..||:::.:..||||...|.|        |.||:.| .:||
Zfish  1126 DCTYSVNYTPTMEG-LYSLMVKYTDDDSFCSPFKFQVLP--------VPGVDYKHPETPVFESGF 1181

  Fly  1510 -----ASLPAEFEIDTKQAGQADINVAIKNPKGKAMQPRLEEVSTGTYVVSFVPDECGTYQCSIK 1569
                 .:.|..|.:|....|:....||:..|.||......::...|:|:|.:.....|.:....|
Zfish  1182 KADVCVNTPQAFIVDGSSIGEPPETVALLTPDGKIKLLSSKDNGDGSYLVEYSASAEGPHSIMAK 1246

  Fly  1570 YGDKEIEGSPFKLEAFPTGEAKKCKLV--------------EQAPKIQTSGSQSHLKVDAREAGD 1620
            |.:.:...|..:..|.|....:|.|.:              .:.|...|:|.:  ::.:|....:
Zfish  1247 YTNDDCFRSIHRFNAIPPHTVRKDKDIGNKKENSSQEGNVHSKPPHTFTNGCR--VEPEANAKAN 1309

  Fly  1621 GAVT----------------------CKIT----------------------------------- 1628
            |::.                      ||..
Zfish  1310 GSIKLADILDNRDKKCEMSCTPKMPGCKSVMDKYNSKEAFRSLQTDPTVNTEQSVCAQSPQLFRI 1374

  Fly  1629 --NKAG--------------SEIVDIDVIEKDGFFDILYALNDPGDYDINVKFGGKD-------- 1669
              :|:|              :|:.::.. ..||.:.:.|...:.|.:.:.||:...|
Zfish  1375 SCSKSGKPPDCVLMIRPDGETELTEVKE-NPDGTYSVKYCPTNEGLHSLMVKYVDDDSFYNPLRF 1438

  Fly  1670 --IPNGSFSIKAV-----------------------------------ESIEQYSHSEYI-EEHT 1696
              :|:.....|.|                                   |.::...|.|.: .|:|
Zfish  1439 HVLPHADSHDKHVINTNEACSRQLEERVSAQIPQTFTTCCNTNEASGTEMLKADDHVEVLNNENT 1503

  Fly  1697 TKVVQQTTQSELV--------------NGKSEITYRSVAFEK----------------------- 1724
            |.....|.:...|              :..:...||  .|:.
Zfish  1504 TSATTHTPEPSAVRNATLEDFQRHQPPSSHTSSGYR--GFQNKVEGRNAIPPAAINQAGFISCDI 1566

  Fly  1725 -LPLPTTGGNVTAEVRMPSGKVDKPVIQDNRDGTVSVKYDPREEGSHELVVKYNGEPVQGSPFKF 1788
             ||...:.|.:|.||..||||..:|.:.||:||||.:|:||.|||.|::::|.....:...|.::
Zfish  1567 VLPGDLSEGEITGEVITPSGKRAQPDMIDNKDGTVVMKFDPSEEGLHQILIKSAENDIPELPLQY 1631

  Fly  1789 HVDSITSGYVTAYGPGLTHGVTGEPANFTISTKGASAGGLTMAVEGPSKADINYHDNKDGTVSVQ 1853
            :.:|:.:....|||.||..|:..|.|.|||..:.:::..|.:.:||||:||::..||:|||.||.
Zfish  1632 YANSLANRSPVAYGRGLVCGIANETATFTICQEDSASSELDITIEGPSEADVHCLDNEDGTCSVS 1696

  Fly  1854 YLPTAPGEYQVSVRFGDKHIKGSPYFAKITGEGRKRNQISVGSCSEVTMPGDITDDDLRALNASI 1918
            ||||.||:|::.|:..|..|.|||:.||||....:::::.:||..:.|:  |||::|:..|:|||
Zfish  1697 YLPTEPGDYEIQVQHNDVPIPGSPFKAKITDGHMRKSEVKLGSAVDFTL--DITEEDISQLSASI 1759

  Fly  1919 QAPSGLEEPCFLKRMPTGNIGISFTPREIGEHLVSVKRLGKHINNSPFKVTVCEREVGDAKKVKV 1983
            .:|:|.:.||.||.....::||||.|||.||||||:.:.|:|::|||..:::.:.|:|||.|||.
Zfish  1760 MSPTGNDVPCLLKTQADSHLGISFIPREAGEHLVSIMKDGEHVSNSPISLSISQAEIGDASKVKA 1824

  Fly  1984 SGTGLKEGQTHADNIFSVDTRNAGFGGLSVSIEGPSKAEIQCTD-KDDGTLNISYKPTEPGYYIV 2047
            .|.||..|.|...:.|.|||.:||:|||:|.||||||.::...: ::|||.||||.|.:||.|.:
Zfish  1825 FGPGLHTGHTFCKSEFVVDTWDAGYGGLTVVIEGPSKVDVHTKELENDGTCNISYCPIKPGSYKI 1889

  Fly  2048 NLKFADHHVEGSPFTVKVAGEGSNRKREKIQRERDAVPITEIGSQCKLTFKMPGITSFDLAACVT 2112
            ::||:|.|:.|||||..|..:|  ..||.|...:.|.|...|||:|.|.||:..:....::|.|.
Zfish  1890 SIKFSDEHIPGSPFTAVVKDQG--LMRENITYNQKAAPTASIGSECSLAFKLQDVDPGTMSAHVY 1952

  Fly  2113 SPSNVTEDAEI-QEVEDGLYAVHFVPKELGVHTVSVRYSEMHIPGSPFQFTVGPLRDSGSHLVKA 2176
            .||....:|.| ......:|.|.|:.||:||:.||::.....|.|.|.|:|||||...||..|:.
Zfish  1953 EPSGSFGEAVILPSTGRDIYVVSFLAKEMGVYNVSIQNKGQTISGCPLQYTVGPLGRGGSEKVQV 2017

  Fly  2177 GGSGLERGVVGEAAEFNVWTREAGGGSLAISVEGPSKADIEFKDRKDGSCDVSYKVTEPGEYRVG 2241
            .|..|:..:....|:||:|:||||.|:|::|||||.:.::.|.::.||||.|:|...:||:|.|.
Zfish  2018 WGQSLQTALATVPADFNIWSREAGAGALSVSVEGPGEIELLFDEQMDGSCIVTYTAQQPGDYEVS 2082

  Fly  2242 LKFNDRHIPDSPFKVYVSPDAGDAHKLEVQQFPQGNIQADAPYQFMVRKNGAKGELDAKIVAPSG 2306
            :.|::.|:..|||.|                                           .::|.:.
Zfish  2083 VMFDEDHVSQSPFLV-------------------------------------------SVIAATD 2104

  Fly  2307 TDDDCFIQVIDGEMYSVRFYPRENGIHAIHVKFNGVHIPDSPFRIKVGKDVADPAAVHASGNGLD 2371
            |                                                .|:|...:
Zfish  2105 T------------------------------------------------AVSDQTQL-------- 2113

  Fly  2372 EVKTGHKADFIINTCNAGVGTLAVSIDGPSKVAMDCTEVEEGYKVRYTPLLPGEHYITVKYNNMH 2436
                          ||   |....|:.||
Zfish  2114 --------------CN---GHGEASLSGP------------------------------------ 2125

  Fly  2437 IVGSPFKVNATGDKLADEGAQETSTVIVETVQKVAKGGKNTGVHLPTFKSDASKVVSKGMGLKKA 2501
                  ::|.|.|..|:                            |...||||||:..|.||.|.
Zfish  2126 ------QINTTSDSSAE----------------------------PVLLSDASKVICHGPGLSKG 2156

  Fly  2502 YIGKQNQFSISATDAGNNILYVGMYGPKGPCEEFHVKHAGHNNYNVQYLVRDRGQYVLLIKWGEE 2566
            ::|::|.|.:..:.||.|:|:|||:||..|||...:.|.|...|.:.|.|::||:|||.:|||:|
Zfish  2157 FLGRKNTFYVDCSKAGRNLLFVGMHGPTVPCERVSIIHMGQCQYRINYAVKERGKYVLAVKWGDE 2221

  Fly  2567 HIPGSPFQIDV 2577
            |||||||.|.|
Zfish  2222 HIPGSPFYISV 2232

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cher	NP_001262659.2	CH_dFLNA-like_rpt1	175..297	CDD:409160	80/118 (68%)
		CH_dFLNA-like_rpt2	298..415	CDD:409164	68/116 (59%)
		IG_FLMN	432..527	CDD:214720	1/94 (1%)
		IG_FLMN	532..627	CDD:214720	1/94 (1%)
		IG_FLMN	631..724	CDD:214720	35/92 (38%)
		IG_FLMN	728..815	CDD:214720	46/87 (53%)
		IG_FLMN	821..913	CDD:214720	34/124 (27%)
		IG_FLMN	918..1001	CDD:214720	25/85 (29%)
		Filamin	1012..1098	CDD:395505	25/97 (26%)
		IG_FLMN	1109..1196	CDD:214720	37/86 (43%)
		Filamin	1197..1293	CDD:395505	21/101 (21%)
		IG_FLMN	1302..1392	CDD:214720	26/91 (29%)
		IG_FLMN	1395..1490	CDD:214720	28/94 (30%)
		IG_FLMN	1494..1587	CDD:214720	23/104 (22%)
		IG_FLMN	1606..1682	CDD:214720	18/193 (9%)
		IG_FLMN	<1731..1791	CDD:214720	24/59 (41%)
		IG_FLMN	1797..1884	CDD:214720	41/86 (48%)
		IG_FLMN	1978..2067	CDD:214720	46/89 (52%)
		Filamin	<2111..2159	CDD:395505	16/48 (33%)
		IG_FLMN	2172..2260	CDD:214720	35/87 (40%)
		IG_FLMN	2265..2354	CDD:214720	2/88 (2%)
		IG_FLMN	2360..2448	CDD:214720	7/87 (8%)
		IG_FLMN	2488..2577	CDD:214720	45/88 (51%)
flnbb	XP_021325608.1	CH_SF	14..138	CDD:469584	83/125 (66%)
		CH_SF	137..251	CDD:469584	67/113 (59%)
		IG_FLMN	265..356	CDD:214720	36/288 (13%)
		IG_FLMN	360..443	CDD:214720	42/82 (51%)
		IG_FLMN	456..545	CDD:214720	32/88 (36%)
		IG_FLMN	600..683	CDD:214720	25/86 (29%)
		IG_FLMN	693..774	CDD:214720	23/90 (26%)
		IG_FLMN	806..894	CDD:214720	39/91 (43%)
		IG_FLMN	985..1057	CDD:214720	27/92 (29%)
		IG_FLMN	1072..1163	CDD:214720	28/93 (30%)
		IG_FLMN	1187..1247	CDD:214720	13/59 (22%)
		IG_FLMN	1369..1442	CDD:214720	10/73 (14%)
		IG_FLMN	<1574..1625	CDD:214720	23/50 (46%)
		IG_FLMN	1642..1728	CDD:214720	42/85 (49%)
		IG_FLMN	1736..1814	CDD:214720	35/79 (44%)
		IG_FLMN	1819..1909	CDD:214720	46/89 (52%)
		IG_FLMN	2013..2102	CDD:214720	35/131 (27%)
		IG_FLMN	2143..2232	CDD:214720	45/88 (51%)