DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cher and flnb

DIOPT Version :9

Sequence 1:NP_001262659.2 Gene:cher / 42066 FlyBaseID:FBgn0014141 Length:2577 Species:Drosophila melanogaster
Sequence 2:XP_021330210.1 Gene:flnb / 563023 ZFINID:ZDB-GENE-041026-1 Length:2239 Species:Danio rerio


Alignment Length:2672 Identity:802/2672 - (30%)
Similarity:1185/2672 - (44%) Gaps:720/2672 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   179 DLAEDAQWKKIQQNTFTRWANEHLKTIDRSINNLETDLSDGLRLIALIEVLSQKRM-PKYNKRPT 242
            :||:||.|||||:||||||.||||::::..|::|:|||||||.||:|:||||.||| .||:.|||
Zfish    14 NLADDAPWKKIQKNTFTRWCNEHLRSVNMRISDLKTDLSDGLVLISLLEVLSHKRMFRKYHTRPT 78

  Fly   243 FRSQKLENVSVALKFLQDEGIKIVNIDSSDIVDCKLKLILGLIWTLILHYSISMPMWDGEDDKQL 307
            ||..||:||||||:||..|.:|:|:|||..|||..|||||||:||||.|||||.|:|  ||:...
Zfish    79 FRQLKLDNVSVALEFLDHEKVKLVSIDSKAIVDGNLKLILGLVWTLIQHYSISTPVW--EDEAND 141

  Fly   308 NGSGHTPKQRLLNWIHAKIPDLPINNFTNDWTTGKAVGALVDACAPGLCPDWELWDPKDAVQNAS 372
            :.|..||:.|||.||..|:|:|||.||:.||..|||:|||||..|||||||||.||....|.|..
Zfish   142 SVSKLTPEMRLLGWIQNKVPELPITNFSQDWQDGKALGALVDGLAPGLCPDWESWDSVHRVSNTK 206

  Fly   373 EAMGLADDWLNVRQLIKPEELVNPNVDEQSMMTYLSQYPNSKLKTGAPLRPKTNPNSIPPPRVRA 437
            |||..|||||.|.|||.|||:::|.|||||:|||||.:|.::||.||||:||    .:|.|:.  
Zfish   207 EAMQQADDWLGVPQLIAPEEILDPAVDEQSVMTYLSLFPKARLKPGAPLKPK----KVPKPKA-- 265

  Fly   438 YGPGIEPIGPVVGAPANFTVETFSAGKGSVDVDIQGPNGEIEKADVRFNNDKNLTYTVSYIPKSE 502
                                                                             
Zfish   266 ----------------------------------------------------------------- 265

  Fly   503 GSHKVAVKFSGRDIPKSPFPVKVEGHAGDASKVKVTGPGIQPNGVTIKKPTFFDILAKDAGRGVP 567
                                                                             
Zfish   266 ----------------------------------------------------------------- 265

  Fly   568 EVIIIDPANHKTSVAAKVRQLENDTWRCEYVTALQGLHSVNVFYAGTPIPNSPFPVKVAPLSDAR 632
                                       |                                     
Zfish   266 ---------------------------C------------------------------------- 266

  Fly   633 KVRASGRGLQATGVRVGDDADFKIYTEGAGEGEPEVRVIGPGGMNQNVMQSKVDGNTYECHYYPT 697
              ||:|||||:.|:||...|:||:.|..||.|..:|.:..|.|...:|.|.::....:...|.|:
Zfish   267 --RATGRGLQSKGIRVEQLAEFKVDTCRAGPGNLDVHIRDPSGREVSVTQKELFKGVFGFQYTPS 329

  Fly   698 KEGRYVIMVTFAGQEVAKSPFEVKVGPKK-ESSIVAYGPGLSSGVIGYPAAFVVETNG-ETGALG 760
            .||.:.:.:|:.||.::||||:|.|||:. ...|..:||||..|.:|.||.|:||:.| ::|.||
Zfish   330 AEGDHTVDITWVGQHISKSPFKVNVGPEAGPQKIRVWGPGLEGGTVGSPAQFMVESVGADSGMLG 394

  Fly   761 FTVAGPSQAEIECHDNGDGSALVKYHPTAVGEYAVHILCDNEDIPKSPFIAQILPRT-DFHPELV 824
            |.:.|||||:|.|.|:.|||.||::.||..||||||::||:|:|..|||:|.|.|:: .|||:.|
Zfish   395 FAIEGPSQAKIACDDHNDGSCLVRFWPTEAGEYAVHVMCDDEEIQDSPFMASIRPKSKGFHPDKV 459

  Fly   825 KASGPGLEKNGVTINQPTSFTVDPSKAGNAPLDVVVQDVFGTKLPVELKNNPDGTKKVTYTPTSG 889
            |..|||:.:.|..||....|.||..:||...|.|..|...|..:.|.:.:...|....:|||:|.
Zfish   460 KVEGPGVSQTGCVINLQNEFIVDTRQAGEGELAVFAQRADGECVDVTISSEQSGVFVCSYTPSSL 524

  Fly   890 VPHTVEVNYGGVSTPNS---------------------------------------PHRVYVG-- 913
            ..||:.|.:|||..|.|                                       |..|:.|  
Zfish   525 SKHTIAVTWGGVMVPGSPFIVTPRRIKITPCSPVWFKPDGSEMCYSDEELDLDEDFPENVHPGGR 589

  Fly   914 ------------VPVDAAKVQAFGPWLQPGVRPNAATHFNVDAREAGDAELKVKIIHEETKIEVP 966
                        .|.||.||.|.||.|..||....| .|.:|...||...|.|::   :...||.
Zfish   590 GELVMNVFSPSNTPADATKVNAHGPGLTEGVVGEQA-EFIIDTSRAGSGRLAVRV---DGPSEVT 650

  Fly   967 CRIIDNEDNTYSVEVIPPSKGAYTTTMTYGGQRV---PLGEKVVVEQTVDVSKIKVDGLEPTAPL 1028
            .:.:|::|.|.:|..:|...|.|...:.:....:   |.|..  :...||.||:.|        .
Zfish   651 LQCLDDQDGTCTVLYLPTEHGMYQINVLFDNSHIPGSPFGAN--IHHPVDPSKVLV--------T 705

  Fly  1029 NSLQQFRIITHG---------LPKADLAVTITSPSGNRIKAHIIPTAEG-FLVNFTPTQLGEYLL 1083
            ||..|..|:...         :...||:|...|.||..::..:....:| :.|.:.|...|.|.|
Zfish   706 NSALQHGIVGESCIVNIDCAKVGSEDLSVQAVSDSGVVVETEVKENDDGTYTVVYVPRTGGVYTL 770

  Fly  1084 SICFGGTPITPRPFRLQ---------------CLTG---SDSNKVQAFGPGLERGIVGQPAEFMI 1130
            .:.:||..:......::               .:.|   :|:::|.|.|.||::|::|.|..|.:
Zfish   771 LLKYGGKVLPVHKVMVEQKVYKSHVKVSRRGGVVVGERETDASQVVASGLGLQKGLIGHPNMFCL 835

  Fly  1131 DTRGAGQGGLGVTVEGPCEAAINCRDNGDGTCNVAYLPTEAGDYTVNITFNERHITGSPFQPLIV 1195
            :|| :....||||||||.:..:.|:|.|.|...|.|.||..|:|.::||..|..|.||||   :|
Zfish   836 NTR-SPVDDLGVTVEGPSDCQVTCKDGGQGVYGVEYTPTVPGEYKISITSGENSIPGSPF---VV 896

  Fly  1196 PVPNLKNTRVSGIGIQPHGVIM--NAATDFMVDMSKVGSNIDSGKLSCAIFDPMGHVLPSKIVQG 1258
            .|.::.||..||..:|. |:.:  ||.|...: :...||.:.....:..:.|....:.|..:...
Zfish   897 SVDDVSNTAGSGDCLQA-GICISSNAVTSQEI-VKHNGSRMHRASPASLVKDRKPLLDPQSLYGS 959

  Fly  1259 PTDDIFRIMYTPFEAGRHTIELMYDNIPVPGSPFVVNVKSGCDPARCKAYGPGLEKGLTNQKNK- 1322
            .:.:.|:.:  | :.||..                 .:.|..|........||::.|:..:..: 
Zfish   960 SSPNQFQAL--P-KYGRDK-----------------ELSSAHDLNMTDIIAPGIKGGICGKTPQG 1004

  Fly  1323 FTVETKGAGNGGLSLAIEGPSEAK--MTCTDNRDGSCDVDYLATDPGEYDITIRFADKHIPGSPF 1385
            ||:....:|....::|:..|..:|  :..||||||||...||.|..|.:.:.::|.::......|
Zfish  1005 FTISCSSSGESPNAVAVVRPDGSKEFLELTDNRDGSCSGVYLPTMDGCHSLIVQFPNEESFNRQF 1069

  Fly  1386 RVLVEETVDPSKVKVYGPGIEHGQVRESVPTFFNVDVGEAGPGRIAVKLTNSEGIPVDNLRVEDK 1450
            :||.  |.:.::|.|.|||:..|...:...||. :|...:......|.:....||. :.:.|.|.
Zfish  1070 QVLA--TDELAEVNVSGPGLTSGMCAQCPQTFI-IDCTSSRKTLQFVTMMTPNGIS-EIMEVRDN 1130

  Fly  1451 GNCIYAVHYVPPKAGSVLTCQVKFSEVEVPCSPFVMTVFPKSEPTKVKVKGVNEK-KKTP----- 1509
            |:|.|:|.|.|...| :.:..||:::.:..||||...|.|        |.||:.| .:||     
Zfish  1131 GDCTYSVSYTPAMEG-LYSLMVKYTDDDSFCSPFKFQVLP--------VPGVDYKHPETPVFESG 1186

  Fly  1510 ------ASLPAEFEIDTKQAGQADINVAIKNPKGKAMQPRLEEVSTGTYVVSFVPDECGTYQCSI 1568
                  .:.|..|.:|....|:....||:..|.||......::...|:|:|.:.....|::...:
Zfish  1187 FKADVCVNTPQAFIVDGSSIGEPPETVALLTPDGKIKLLSSKDNGDGSYLVEYSASAEGSHSIMV 1251

  Fly  1569 KYGDKEIEGSPFKLEAFPTGEAKKCKLV--------------EQAPKIQTSGSQSHLKVDAREAG 1619
            ||.:.:...|..:..|.|...|:|.|.:              .:.|...|:|.:...:.:|:..|
Zfish  1252 KYTNDDCFRSIHRFNAIPPHSARKDKDIGNKKENSSQEGNVHSKPPHTFTNGCRGEPEANAKANG 1316

  Fly  1620 DGAVTCKITNK------------AGSEIVDIDVIEKDGFFDI------------------LYALN 1654
            ...|...:.|:            :|.:.|......|:.|..:                  |:.::
Zfish  1317 SIKVADIMDNRDKKCEMPCTPKMSGCKSVMDKYNSKEAFRSLQTDPTVNTEQSVCAQSPQLFRIS 1381

  Fly  1655 -----DPGDYDINVKFGG-------KDIPNGSFSIKAVESIE-------QY-------------- 1686
                 .|.|..:.::..|       |:.|:|::|:|...:.|       :|              
Zfish  1382 CSKSGKPPDCVLMIRPDGETELTEVKENPDGTYSVKYCPTNEGLHSLMVKYVDDDSFYNPLRFHV 1446

  Fly  1687 -----SHSEYI-----------EEHTTKVVQQTTQS-------------------ELVNGK---S 1713
                 ||.:::           ||..:..:.||..:                   |::|.:   |
Zfish  1447 LPHADSHDKHVINTTEACSRQLEERVSAQIPQTFTTCCNTNEASGTEMLKADDHVEVLNNENTTS 1511

  Fly  1714 EITY-------RSVAFEK--------------------------------------------LPL 1727
            |.|:       |:...|.                                            ||.
Zfish  1512 ETTHTPEPSAVRNATLEDFQRHQPPSSHTSSGYRGFQNKVEGRNAIPPAAINQAGFISCDIVLPG 1576

  Fly  1728 PTTGGNVTAEVRMPSGKVDKPVIQDNRDGTVSVKYDPREEGSHELVVKYNGEPVQGSPFKFHVDS 1792
            ..:.|.:|.||..||||..:|.:.||:||||.:|:||.|||.|::::|.....:...|.:::.:|
Zfish  1577 DLSEGEITGEVITPSGKRAQPDMIDNKDGTVVMKFDPSEEGLHQILIKSAENDIPELPLQYYANS 1641

  Fly  1793 ITSGYVTAYGPGLTHGVTGEPANFTISTKGASAGGLTMAVEGPSKADINYHDNKDGTVSVQYLPT 1857
            :.:....|||.||..|:..|.|.|||..:.:::..|.:.:||||:||::..||:|||.||.||||
Zfish  1642 LANRSPVAYGRGLVCGIANETATFTICQEDSASSELDITIEGPSEADVHCLDNEDGTCSVSYLPT 1706

  Fly  1858 APGEYQVSVRFGDKHIKGSPYFAKITGEGRKRNQISVGSCSEVTMPGDITDDDLRALNASIQAPS 1922
            .||:|::.|:..|..|.|||:.||||....:::::.:||..:.|:  |||::|:..|:|||.:|:
Zfish  1707 EPGDYEIQVQHNDVPIPGSPFKAKITDGHMRKSEVKLGSAVDFTL--DITEEDISQLSASIMSPT 1769

  Fly  1923 GLEEPCFLKRMPTGNIGISFTPREIGEHLVSVKRLGKHINNSPFKVTVCEREVGDAKKVKVSGTG 1987
            |.:.||.||.....::|:||.|||.||||||:.:.|:|::|||..:::.:.|:|||.|||..|.|
Zfish  1770 GNDVPCLLKTQADSHLGVSFIPREAGEHLVSIMKDGEHVSNSPISLSISQAEIGDASKVKAFGPG 1834

  Fly  1988 LKEGQTHADNIFSVDTRNAGFGGLSVSIEGPSKAEIQCTD-KDDGTLNISYKPTEPGYYIVNLKF 2051
            |..|.|...:.|.|||.:||:|||:|.||||||.::...: ::|||.||||.|.:||.|.:::||
Zfish  1835 LHTGHTFCKSEFVVDTWDAGYGGLTVVIEGPSKVDVHTEELENDGTCNISYCPIKPGSYKISIKF 1899

  Fly  2052 ADHHVEGSPFTVKVAGEGSNRKREKIQRERDAVPITEIGSQCKLTFKMPGITSFDLAACVTSPSN 2116
            :|.|:.|||||..|..:|  ..||.|...:.|.|...|||:|.|.||:|.:....::|.|..||.
Zfish  1900 SDEHIPGSPFTAVVKDQG--LMRENITYNQKAAPTASIGSECSLAFKLPDVDPGTMSAHVYEPSG 1962

  Fly  2117 VTEDAEI-QEVEDGLYAVHFVPKELGVHTVSVRYSEMHIPGSPFQFTVGPLRDSGSHLVKAGGSG 2180
            ...:|.| ......:|.|.|:.||:||:.||::.....|.|.|.|:|||||...||..|:..|..
Zfish  1963 SFGEAVILPRTGRDIYVVSFLAKEMGVYNVSIQNKGQTISGCPLQYTVGPLGRGGSEKVQVWGQS 2027

  Fly  2181 LERGVVGEAAEFNVWTREAGGGSLAISVEGPSKADIEFKDRKDGSCDVSYKVTEPGEYRVGLKFN 2245
            |:..:....|:||:|:||||.|:|::|||||.:.::.|.::.||||.|:|...:||:|.|.:.||
Zfish  2028 LQTALATVPADFNIWSREAGAGALSVSVEGPGEIELHFDEQMDGSCIVTYTAQQPGDYEVSVMFN 2092

  Fly  2246 DRHIPDSPFKVYVSPDAGDAHKLEVQQFPQGNIQADAPYQFMVRKNGAKGELDAKIVAPSGTDDD 2310
            :.|:..|||.|                                           .::|.:.|   
Zfish  2093 EDHVSQSPFLV-------------------------------------------SVIAATDT--- 2111

  Fly  2311 CFIQVIDGEMYSVRFYPRENGIHAIHVKFNGVHIPDSPFRIKVGKDVADPAAVHASGNGLDEVKT 2375
                                                         .|:|...:            
Zfish  2112 ---------------------------------------------AVSDQTQL------------ 2119

  Fly  2376 GHKADFIINTCNAGVGTLAVSIDGPSKVAMDCTEVEEGYKVRYTPLLPGEHYITVKYNNMHIVGS 2440
                      ||   |....|:.||                                        
Zfish  2120 ----------CN---GHGEASLSGP---------------------------------------- 2131

  Fly  2441 PFKVNATGDKLADEGAQETSTVIVETVQKVAKGGKNTGVHLPTFKSDASKVVSKGMGLKKAYIGK 2505
              ::|.|.|..|:                            |...||||||:..|.||.|.::|:
Zfish  2132 --QINTTSDSSAE----------------------------PVLLSDASKVICHGPGLSKGFLGR 2166

  Fly  2506 QNQFSISATDAGNNILYVGMYGPKGPCEEFHVKHAGHNNYNVQYLVRDRGQYVLLIKWGEEHIPG 2570
            :|.|.:..:.||.|:|:|||:||..|||...:.|.|...|.:.|.|::||:|||.:|||:|||||
Zfish  2167 KNTFYVDCSKAGRNLLFVGMHGPTVPCERVSIIHMGQCQYRINYAVKERGKYVLAVKWGDEHIPG 2231

  Fly  2571 SPFQIDV 2577
            |||.|.|
Zfish  2232 SPFYISV 2238

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cherNP_001262659.2 CH_dFLNA-like_rpt1 175..297 CDD:409160 80/118 (68%)
CH_dFLNA-like_rpt2 298..415 CDD:409164 68/116 (59%)
IG_FLMN 432..527 CDD:214720 1/94 (1%)
IG_FLMN 532..627 CDD:214720 1/94 (1%)
IG_FLMN 631..724 CDD:214720 35/92 (38%)
IG_FLMN 728..815 CDD:214720 47/87 (54%)
IG_FLMN 821..913 CDD:214720 34/130 (26%)
IG_FLMN 918..1001 CDD:214720 25/85 (29%)
Filamin 1012..1098 CDD:395505 23/95 (24%)
IG_FLMN 1109..1196 CDD:214720 37/86 (43%)
Filamin 1197..1293 CDD:395505 18/97 (19%)
IG_FLMN 1302..1392 CDD:214720 25/92 (27%)
IG_FLMN 1395..1490 CDD:214720 28/94 (30%)
IG_FLMN 1494..1587 CDD:214720 23/104 (22%)
IG_FLMN 1606..1682 CDD:214720 18/117 (15%)
IG_FLMN <1731..1791 CDD:214720 24/59 (41%)
IG_FLMN 1797..1884 CDD:214720 41/86 (48%)
IG_FLMN 1978..2067 CDD:214720 46/89 (52%)
Filamin <2111..2159 CDD:395505 16/48 (33%)
IG_FLMN 2172..2260 CDD:214720 36/87 (41%)
IG_FLMN 2265..2354 CDD:214720 2/88 (2%)
IG_FLMN 2360..2448 CDD:214720 7/87 (8%)
IG_FLMN 2488..2577 CDD:214720 45/88 (51%)
flnbXP_021330210.1 SAC6 21..>248 CDD:227401 145/228 (64%)
IG_FLMN 265..356 CDD:214720 36/288 (13%)
IG_FLMN 360..443 CDD:214720 43/82 (52%)
IG_FLMN 456..545 CDD:214720 32/88 (36%)
IG_FLMN 606..689 CDD:214720 25/86 (29%)
IG_FLMN 699..780 CDD:214720 21/88 (24%)
IG_FLMN 812..900 CDD:214720 39/91 (43%)
Filamin 991..1063 CDD:332480 22/71 (31%)
IG_FLMN 1078..1169 CDD:214720 28/93 (30%)
Filamin 1193..1253 CDD:332480 13/59 (22%)
Filamin 1375..1448 CDD:332480 11/72 (15%)
Filamin <1580..1631 CDD:332480 23/50 (46%)
IG_FLMN 1648..1734 CDD:214720 42/85 (49%)
IG_FLMN 1742..1820 CDD:214720 34/79 (43%)
IG_FLMN 1825..1915 CDD:214720 46/89 (52%)
IG_FLMN 2019..2108 CDD:214720 36/131 (27%)
IG_FLMN 2149..2238 CDD:214720 45/88 (51%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 158 1.000 Domainoid score I4073
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D24684at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100805
Panther 1 1.100 - - O PTHR38537
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X791
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
65.920

Return to query results.
Submit another query.