Protein Alignment cher and flna

DIOPT Version :10

• Sequence 1: NP_001262659.2
• Gene: cher / 42066
• FlyBaseID: FBgn0014141
• Length: 2577
• Species: Drosophila melanogaster
• Sequence 2: XP_009295045.3
• Gene: flna / 562529
• ZFINID: ZDB-GENE-030131-2145
• Length: 2552
• Species: Danio rerio
• Alignment Length: 2560
• Identity: 1184/2560 - (46%)
• Similarity: 1601/2560 - (62%)
• Gaps: 186/2560 - (7%)

  Fly   171 DEDMEA-ERDLAEDAQWKKIQQNTFTRWANEHLKTIDRSINNLETDLSDGLRLIALIEVLSQKRM 234
            |.||.| |:||||||.||||||||||||.|||||.:::.|.||:||||||||||||:||||||:|
Zfish    26 DADMPATEKDLAEDAPWKKIQQNTFTRWCNEHLKCVNKRIANLQTDLSDGLRLIALLEVLSQKKM 90

  Fly   235 -PKYNKRPTFRSQKLENVSVALKFLQDEGIKIVNIDSSDIVDCKLKLILGLIWTLILHYSISMPM 298
             .|||:|||||..:||||||||:||..|.||:|:|||..|||..|||||||||||||||||||||
Zfish    91 FRKYNQRPTFRQMQLENVSVALEFLDIENIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPM 155

  Fly   299 WDGEDDKQLNGSGHTPKQRLLNWIHAKIPDLPINNFTNDWTTGKAVGALVDACAPGLCPDWELWD 363
            ||.|::.: .....|||||||.||..|:|:|||.||:.||.:|||:|||||:|||||||||:.||
Zfish   156 WDEEEESE-ESKQKTPKQRLLGWIQNKLPELPITNFSRDWQSGKALGALVDSCAPGLCPDWDSWD 219

  Fly   364 PKDAVQNASEAMGLADDWLNVRQLIKPEELVNPNVDEQSMMTYLSQYPNSKLKTGAPLRPKTNPN 428
            ....|.||.|||..|||||.|.|:|.|||:|:|||||.|:||||||:|.:|||.|||||||.||.
Zfish   220 QTKPVDNAREAMQQADDWLGVPQVITPEEIVDPNVDEHSVMTYLSQFPKAKLKPGAPLRPKLNPK 284

  Fly   429 SIPPPRVRAYGPGIEPIGPVVGAPANFTVETFSAGKGSVDVDIQGPNGEIEKADVRFNNDKNLTY 493
                 :.|||||||||.|.||...|.|||||.|||:|.|.|.::.|.|..|:|.|..|||||.||
Zfish   285 -----KARAYGPGIEPTGNVVMKKAVFTVETISAGQGEVLVYVEDPAGHREEAKVTANNDKNRTY 344

  Fly   494 TVSYIPKSEGSHKVAVKFSGRDIPKSPFPVKVEGHAGDASKVKVTGPGIQPNGVTIKKPTFFDIL 558
            :|.|:||..|.|||.|.|:|:.|.||||.|.|....||:|||...|||::|.|....|.|:||:.
Zfish   345 SVFYVPKVTGQHKVTVLFAGQHISKSPFEVDVGMAQGDSSKVTAQGPGLEPAGNIANKTTYFDVY 409

  Fly   559 AKDAGRGVPEVIIIDPANHKTSVAAKVRQLENDTWRCEYVTALQGLHSVNVFYAGTPIPNSPFPV 623
            ...||.|..||:|:||:..|.:|...|....|.::||.|....:|.|.:.:.:||..|..||:.|
Zfish   410 TAGAGVGEVEVVIMDPSGKKDTVECSVEDKGNSSYRCTYKPTQEGQHIIYITFAGGQISKSPYTV 474

  Fly   624 KVAPLSDARKVRASGRGLQATGVRVGDDADFKIYTEGAGEGEPEVRVIGPGGMNQNVMQSKVDGN 688
            .|....:.....|.|||||..|:||.:.|:||:||:|||.|:.:|.:.||.|:.:...:..:...
Zfish   475 NVGEACNPSLCTAKGRGLQPKGLRVKETAEFKVYTKGAGTGDLKVTIKGPKGLEEPCKKKDLGDG 539

  Fly   689 TYECHYYPTKEGRYVIMVTFAGQEVAKSPFEVKVGPKK-ESSIVAYGPGLSSGVIGYPAAFVVET 752
            .|...|||:..|.|:|.:|:.||.:.:||||||:|.:. ...:.|:||||.|||:|..|.||||.
Zfish   540 VYSFDYYPSTPGNYIITITWGGQHIPRSPFEVKIGSEAGPQQVRAWGPGLESGVVGKSADFVVEA 604

  Fly   753 NG-ETGALGFTVAGPSQAEIECHDNGDGSALVKYHPTAVGEYAVHILCDNEDIPKSPFIAQILPR 816
            .| :.|.|||:|.|||.|:|||.|.||||..|:|.||..||||||:||.||||..|||:|:|:|.
Zfish   605 VGDDVGTLGFSVEGPSPAKIECDDKGDGSCDVRYWPTEPGEYAVHVLCKNEDIQLSPFMAEIMPA 669

  Fly   817 --TDFHPELVKASGPGLEKNGVTINQPTSFTVDPSKAGNAPLDVVVQDVFGTKLPVELKNNPDGT 879
              .||:|:.|||.||||:.:|:::.:|..||||....|.|||.:..||..|..:.|::|:|.:||
Zfish   670 PGKDFYPDKVKAYGPGLQSSGLSVGKPAEFTVDAKLGGKAPLKIQAQDRDGNPVDVQVKDNGNGT 734

  Fly   880 KKVTYTPTSGVPHTVEVNYGGVSTPNSPHRVYVGVPVDAAKVQAFGPWL-QPGVRPNAATHFNVD 943
            ...:|||...|.|||.|::|||:.|.||.|:.:|......||:..||.: :.|::....|:|.||
Zfish   735 YSCSYTPRKPVKHTVMVSWGGVNIPESPFRMNIGAGCHPNKVKVSGPGVAKTGLKAYDPTYFTVD 799

  Fly   944 AREAGDAELKVKI-----IHEETKIEVPCRIIDNEDNTYSVEVIPPSKGAYTTTMTYGGQRVPLG 1003
            ..|||..::.:.|     :....:.::...||.|:::|::|:..||..|:||..:.:..|.:|:.
Zfish   800 CAEAGQGDISIGIKCAAGVVGPAEADIDFDIIRNDNDTFTVKYTPPGAGSYTIMVLFADQTIPMT 864

  Fly  1004 E-KVVVEQTVDVSKIKVD-------GLEPTAPL------------------------NSLQQFRI 1036
            . ::.|:.:.|.||:|.:       |:|...|.                        ::::.|.|
Zfish   865 PIRIKVDPSHDASKVKAEGPGLSRSGVELNKPTHFTVNTKAAGKAKLDAQFTGPNKGDAVRDFDI 929

  Fly  1037 I-----------------------THG---LPKADLAVTI------------------------- 1050
            |                       |:|   :||:..||.|
Zfish   930 IDNHDGTHTVKYTPVQQGNMGLNVTYGGDPIPKSPFAVAIAPSLDLSKVKVAGLGSKMTVGKDQE 994

  Fly  1051 ------------------TSPSGNRIKAHIIP--TAEGFLVNFTPTQLGEYLLSICFGGTPITPR 1095
                              |.||...:...:.|  :.|...|.|.|...|.|.:.:.:.|.||...
Zfish   995 ITVKSKGAGGQGKVGAKVTGPSAKSVPCKVEPGLSPETSQVRFIPRDKGPYEVELTYDGAPIPGS 1059

  Fly  1096 PFRLQCLTGSDSNKVQAFGPGLERGIVGQPAEFMIDTRGAGQGGLGVTV--EGPCEAAINCRDNG 1158
            ||.::.:..:|.:||:..||||||..||:|.:|::|...||...|.:.:  :...||.::.:|||
Zfish  1060 PFPIEAIAPTDPSKVRCSGPGLERAKVGEPGQFVVDCTNAGPAELTIEIISDNGTEAEVHIQDNG 1124

  Fly  1159 DGTCNVAYLPTEAGDYTVNITFNERHITGSPFQPLIVPVPNLKNTRVSGIGIQPHGVIMNAATDF 1223
            |||..:.|:|...|.||:.|.:.::.:...|.:..:.|.......:|.|.|::..||...|.|||
Zfish  1125 DGTYTITYVPLYPGAYTLTIRYGDQDVPNFPARLHVEPAVETSGVKVFGPGVEGKGVFREATTDF 1189

  Fly  1224 MVD---MSKVGSNIDSGKLSCAIFDPMGHVLPSKIVQGPTDDIFRIMYTPFEAGRHTIELMYDNI 1285
            .||   ::|.|.|    .:...|.:|.|: ....:::...|..:::.|||:|.|.|::|:.||:.
Zfish  1190 TVDARALTKTGGN----HIKTCINNPSGN-RTEALIRDLGDGTYQVEYTPYEEGTHSVEVAYDSS 1249

  Fly  1286 PVPGSPFVVNVKSGCDPARCKAYGPGLEKGLTNQKNKFTVETKGAGNGGLSLAIEGPSEAKMTCT 1350
            |||.|||.|.|..||||||.:.:||||:.|:||:.|||||||:|||.|||.||:||||||||:||
Zfish  1250 PVPKSPFRVPVTEGCDPARVRVHGPGLQSGITNKPNKFTVETRGAGTGGLGLAMEGPSEAKMSCT 1314

  Fly  1351 DNRDGSCDVDYLATDPGEYDITIRFADKHIPGSPFRVLVEETVDPSKVKVYGPGIEHGQVRESVP 1415
            ||:||||.|:|:..:||.|::.:.:..:.|.||||.|.|.:||||:|||..|.|:.: .||.::|
Zfish  1315 DNKDGSCCVEYIPYEPGTYNLNVTYGGQPITGSPFSVPVHDTVDPTKVKCQGQGLGN-NVRANIP 1378

  Fly  1416 TFFNVDVGEAGPGRIAVKLTNSEGIPVDNLRVEDKGNCIYAVHYVPPKAGSVLTCQVKFSEVEVP 1480
            ..|:||..:||...:.|::...:|: |:...|.|.|:..:.|.|||.:.|. .:..|.:::.|:|
Zfish  1379 QVFSVDASKAGMAPLQVRVQGPKGV-VEPAEVVDNGDQTHTVSYVPTREGP-YSINVLYADEEIP 1441

  Fly  1481 CSPFVMTVFPKSEPTKVKVKGVN-EKKKTPASLPAEFEIDTKQAGQADINVAIKNPKGKAMQPRL 1544
            .||:.:.|.|..:.:||:..|.. .....|||||.||.||.|.||:..:.|.|.:|.||..:..:
Zfish  1442 QSPYKVKVLPTHDASKVRCSGPGLNTTGVPASLPVEFTIDAKDAGEGLLAVQITDPDGKPKKANI 1506

  Fly  1545 EEVSTGTYVVSFVPDECGTYQCSIKYGDKEIEGSPFKLEAFPTGEAKKCKLVEQ----------A 1599
            .:...|||:||:|||..|.|...||||..||..||:::.|.|||:|.||.:...          .
Zfish  1507 RDNQDGTYLVSYVPDMTGRYTILIKYGGDEIPYSPYRIRALPTGDASKCTVTVSIGGHGLGAGVG 1571

  Fly  1600 PKIQTSGSQSHLKVDAREAGDGAVTCKITNKAGSEIVDIDVIE-KDGFFDILYALNDPGDYDINV 1663
            |.||. |.|:.:.|||:.||.|.|||.:....|.| ||:||:| :||.|||.|....||.|.|.|
Zfish  1572 PTIQI-GEQTVITVDAKAAGKGKVTCTVCTPDGGE-VDVDVVENEDGTFDIFYTAPQPGKYVICV 1634

  Fly  1664 KFGGKDIPNGSFSIKAVES------IEQYSHSEYIEEHTTKVVQQ-TTQSEL-VNGKSEITYRSV 1720
            :|||:.|||..|.:.|:|.      ::|..:.:|  .:...:.|. .|..:| :||......|
Zfish  1635 RFGGEHIPNSPFQVTALEGDSPDQLMQQSQNLQY--AYAPNMGQTWATDGQLGMNGLDVAGLR-- 1695

  Fly  1721 AFE-KLPLPTTGGNVTAEVRMPSGKVDKPVIQDNRDGTVSVKYDPREEGSHELVVKYNGEPVQGS 1784
            .|: .:|.....|.:|.:||||||||.||.|.||:||||:|||.|.|.|.||:.:||:|..:.||
Zfish  1696 PFDLVIPFTIQKGEITGDVRMPSGKVAKPDITDNKDGTVTVKYAPTEAGLHEMDIKYDGIHIPGS 1760

  Fly  1785 PFKFHVDSITSGYVTAYGPGLTHGVTGEPANFTISTKGASAGGLTMAVEGPSKADINYHDNKDGT 1849
            |.:|:||.:.||:||||||||.||:..:||.||::||.|..|||::|:||||||||:..||:|||
Zfish  1761 PLQFYVDYVNSGHVTAYGPGLIHGMVNKPAVFTVNTKDAGEGGLSLAIEGPSKADISCTDNQDGT 1825

  Fly  1850 VSVQYLPTAPGEYQVSVRFGDKHIKGSPYFAKITGEGRKR-NQISVGSCSEVTMPGDITDDDLRA 1913
            .:|.|||..||:|.:.|::.||:|.|||:.:||||:...| :.:.|||.:::  |.||.:.||..
Zfish  1826 CTVSYLPVLPGDYNIIVKYNDKNIPGSPFMSKITGDDSMRMSHLKVGSAADI--PLDIGELDLSQ 1888

  Fly  1914 LNASIQAPSGLEEPCFLKRMPTGNIGISFTPREIGEHLVSVKRLGKHINNSPFKVTVCEREVGDA 1978
            |.|::..|||.||||.||.:..|::||||.|:|||||||::|:.|:||.:||..|.:.:.|:|||
Zfish  1889 LTATLTTPSGREEPCLLKMLRNGHVGISFVPKEIGEHLVNIKKNGRHIPSSPISVMINQSEIGDA 1953

  Fly  1979 KKVKVSGTGLKEGQTHADNIFSVDTRNAGFGGLSVSIEGPSKAEIQCTDKDDGTLNISYKPTEPG 2043
            .:|:|:|.||.|.:|.....|.:|||:||:||||:|||||||.:|...|::|||..::|.|||||
Zfish  1954 SRVRVTGQGLSEARTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINTEDQEDGTCKVTYCPTEPG 2018

  Fly  2044 YYIVNLKFADHHVEGSPFTVKVAGEGSNRKREKIQRERDAVPITEIGSQCKLTFKMPGITSFDLA 2108
            .||:|:||||.||.||.|||||.|||  |.:|.|.|:|.|..:..:||||.|:.|:|.|:..|:.
Zfish  2019 NYIINIKFADQHVPGSAFTVKVTGEG--RMKESITRKRRAASVANVGSQCDLSLKIPEISIADMT 2081

  Fly  2109 ACVTSPSNVTEDAEIQEVEDGLYAVHFVPKELGVHTVSVRYSEMHIPGSPFQFTVGPLRDSGSHL 2173
            |.|||||.....|||.|.|:..|.:.|||.|:|||||||:|...|:||||||||||||.:.|:|.
Zfish  2082 AQVTSPSGKVHKAEIMEGENNTYCIRFVPTEMGVHTVSVKYQGQHVPGSPFQFTVGPLGEGGAHK 2146

  Fly  2174 VKAGGSGLERGVVGEAAEFNVWTREAGGGSLAISVEGPSKADIEFKDRKDGSCDVSYKVTEPGEY 2238
            |:|||.||||...|..|||::||||||.|.|:|:|||||||:|.|:||||||..|||.|.|||:|
Zfish  2147 VRAGGPGLERAEAGVPAEFSIWTREAGAGGLSIAVEGPSKAEIAFEDRKDGSSGVSYIVQEPGDY 2211

  Fly  2239 RVGLKFNDRHIPDSPFKVYVSPDAGDAHKLEVQQFPQGNIQADAPYQFMVRKNGAKGELDAKIVA 2303
            .|.:||||.|||||||.|.|:..:.||.:|.|....:..::.:.|..|.|..|||||.:|||:.:
Zfish  2212 EVSIKFNDEHIPDSPFVVPVASPSDDARRLTVASLQESGLKVNQPASFAVSLNGAKGVIDAKVHS 2276

  Fly  2304 PSGTDDDCFIQVIDGEMYSVRFYPRENGIHAIHVKFNGVHIPDSPFRIKVGK--DVADPAAVHAS 2366
            |||..::|.:..||.:.|:|||.|||||::.|.|||||.|||.|||:|:||:  ...||..|.|.
Zfish  2277 PSGALEECCVTEIDEDKYAVRFIPRENGLYLIDVKFNGSHIPGSPFKIRVGETGQAGDPGMVSAY 2341

  Fly  2367 GNGLDEVKTGHKADFIINTCNAGVGTLAVSIDGPSKVAMDCTEVEEGYKVRYTPLLPGEHYITVK 2431
            |.||:...||...:||:||.:||.|.|||:|||||||.|||.|..|||||.|||:.||.:.|::|
Zfish  2342 GAGLEGGTTGSPCEFIVNTSSAGPGALAVTIDGPSKVKMDCQECPEGYKVTYTPMAPGNYLISIK 2406

  Fly  2432 YNN-MHIVGSPFKVNATGDKLAD-EGAQETSTVIVE-------TVQKVAKGGKNTGVHLPTFKSD 2487
            |.. .||||||||...||.:|.: ....|||:|:|:       |.|:.|.|..:         ||
Zfish  2407 YGGPYHIVGSPFKAKITGSRLVNSHSMHETSSVLVDPVTRSMTTSQQAAPGWAS---------SD 2462

  Fly  2488 ASKVVSKGMGLKKAYIGKQNQFSISATDAGNNILYVGMYGPKGPCEEFHVKHAGHNNYNVQYLVR 2552
            ||:||:||:||.|.:||::|.||:..:.||.|:|.||:.|||.||||..|||.|:..|||.|.::
Zfish  2463 ASRVVAKGLGLNKGFIGQKNTFSVDCSKAGRNMLLVGVDGPKVPCEEILVKHLGNRLYNVSYQLK 2527

  Fly  2553 DRGQYVLLIKWGEEHIPGSPFQIDV 2577
            ::|:|:|::|||:|||||||:.|.|
Zfish  2528 EKGEYILVVKWGDEHIPGSPYHITV 2552

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cher	NP_001262659.2	CH_dFLNA-like_rpt1	175..297	CDD:409160	93/123 (76%)
		CH_dFLNA-like_rpt2	298..415	CDD:409164	72/116 (62%)
		IG_FLMN	432..527	CDD:214720	54/94 (57%)
		IG_FLMN	532..627	CDD:214720	36/94 (38%)
		IG_FLMN	631..724	CDD:214720	38/92 (41%)
		IG_FLMN	728..815	CDD:214720	53/87 (61%)
		IG_FLMN	821..913	CDD:214720	41/91 (45%)
		IG_FLMN	918..1001	CDD:214720	24/88 (27%)
		Filamin	1012..1098	CDD:395505	31/187 (17%)
		IG_FLMN	1109..1196	CDD:214720	31/88 (35%)
		Filamin	1197..1293	CDD:395505	32/98 (33%)
		IG_FLMN	1302..1392	CDD:214720	53/89 (60%)
		IG_FLMN	1395..1490	CDD:214720	31/94 (33%)
		IG_FLMN	1494..1587	CDD:214720	39/93 (42%)
		IG_FLMN	1606..1682	CDD:214720	37/76 (49%)
		IG_FLMN	<1731..1791	CDD:214720	34/59 (58%)
		IG_FLMN	1797..1884	CDD:214720	50/86 (58%)
		IG_FLMN	1978..2067	CDD:214720	52/88 (59%)
		Filamin	<2111..2159	CDD:395505	27/47 (57%)
		IG_FLMN	2172..2260	CDD:214720	59/87 (68%)
		IG_FLMN	2265..2354	CDD:214720	42/88 (48%)
		IG_FLMN	2360..2448	CDD:214720	50/88 (57%)
		IG_FLMN	2488..2577	CDD:214720	49/88 (56%)
flna	XP_009295045.3	None