DRSC/TRiP Functional Genomics Resources

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Protein Alignment cher and Macf1

DIOPT Version :10

Sequence 1:NP_001262659.2 Gene:cher / 42066 FlyBaseID:FBgn0014141 Length:2577 Species:Drosophila melanogaster
Sequence 2:XP_063144057.1 Gene:Macf1 / 362587 RGDID:1306057 Length:7663 Species:Rattus norvegicus


Alignment Length:2057 Identity:366/2057 - (17%)
Similarity:621/2057 - (30%) Gaps:809/2057 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   894 VEVNYGGVSTPNSPHRVYVGVPVDAAKVQAF-GPWLQPGVRPNAATHFNV----DAREAGDAELK 953
            |.:..||.|.|  |...|:.  ::.|..|.| ..||...::.:..|..|:    .|.:.|..||.
  Rat  1806 VHLATGGFSLP--PSENYIN--LEEAFHQGFIASWLHSELQSHLRTSKNLIDPNTAEKVGLLELM 1866

  Fly   954 VKII-HEETKIE-VPCR------------------------IIDN-------EDNTYSVEVIPPS 985
            .:.| |:|:.:: :|.:                        :||.       |...::..::.|.
  Rat  1867 QRCISHQESGLKLLPVKQLAGGMVSLKSGGKVSIFRAVQEGLIDRQVTVRLLEAQLFAGGIVDPR 1931

  Fly   986 KGAYTTTMTYGGQRVPLGEKVVVEQTVD--------VSKIKVDGLEPTAPLNSLQQFRIITHGLP 1042
            .|...|           .|:.|....:|        :.:::..|:..||....:.....:|:.|.
  Rat  1932 TGHRLT-----------AEEAVRHNLIDQDMACAILIRQLQTGGIIDTATGERMTIDEAVTNNLV 1985

  Fly  1043 KADLAVTITSPSGNRIKAHIIPTAEGFLVNFTPTQLGEYLLSICFGGTPITPRPFRLQCLTGSDS 1107
            .|.:|:.            |:.:...|:....| :.||.|        |||              
  Rat  1986 AAKIALV------------ILESLWSFMGLLLP-ESGEIL--------PIT-------------- 2015

  Fly  1108 NKVQAFGPGLERGIVGQPAEFMIDTRGAGQGGLGVTVEGPCEAAINCRDNGDGTCNVAYLP---- 1168
                   ..||:|||..                        |.|.....|.. .....:||    
  Rat  2016 -------DALEQGIVSN------------------------ELAHKILHNRQ-QIEALFLPTITE 2048

  Fly  1169 -------TEAGDYTVNITFNERHITGSPFQPLIVPVPNLKNTRVSGIGIQPHGVIMNAATDFMVD 1226
                   ||:|....::..|.|.:.          :|:::          ||..:.::|     :
  Rat  2049 VWSWEKATESGILDKDLANNLRSVC----------IPDMR----------PHIQLADSA-----E 2088

  Fly  1227 MSKVGSNIDSGK--LSC-----------AIFDPMGH------------VLPSKIVQGPTD----- 1261
            .||||  :.:||  |||           .:|..|.|            :|..::|:..|.     
  Rat  2089 QSKVG--VAAGKPPLSCQREGRTSREEKLLFQLMTHSYINAHTGQRLLLLDQELVEMLTSRDEYQ 2151

  Fly  1262 ----DIFRIMYTPFEAGRHTIELMYDNIPVPGSPFVVNVKSGCDPARCKAYGPGLEKGLTNQKNK 1322
                ::|.|.....:..:...||      .||:  :..:.|...|  |::..|...||..:|:| 
  Rat  2152 VGLPEVFEIQPQRLDTSKDLQEL------DPGT--ISQISSARKP--CESQFPSQSKGYPSQEN- 2205

  Fly  1323 FTVETKGAGN--GGLSLAIEGPSE-----AKMTCTDNRDGSCDV----------DYLATDPGEYD 1370
             ..:.||..:  |....:.|.|..     .:...|:| .||..|          ..|.:...|. 
  Rat  2206 -CTQAKGERSVIGRECSSAESPERELFVGEQGAITEN-VGSLKVINKVKLELQSPLLGSRKEEQ- 2267

  Fly  1371 ITIRFADKHIPGSPFRV-LVEETVDPSKVKVYGPGIEHGQVRESVPTFFNVDVGEAGPGRIAVKL 1434
             |..|:::::...|..| ..|.:.|.|.|.......|..:.:....:.|.               
  Rat  2268 -TEMFSEENVSSDPLLVECPEGSEDMSLVLDKDLSTEKSKCQAPTKSSFT--------------- 2316

  Fly  1435 TNSEGIPVDNLRVEDKGNCIYAVHYVPPKAGSVLT-CQVKFSEVEVPCSPFVMTVFPKSEPTK-- 1496
                       |.:::...:.|.| :|.:.|..|| .|.|.|:|:|..|..:.:.| |||..:  
  Rat  2317 -----------RHKEQVKTVKADH-IPSETGIPLTKSQNKTSQVQVDASVSLKSEF-KSEYDEKE 2368

  Fly  1497 ----VKVKGVNEKKKTPASLP------------------------AEFEIDT------------- 1520
                :.|||.:::.:...|:|                        :.||..|             
  Rat  2369 LNETLLVKGSHKQSQEGQSVPDGQMVVLEKADTEDNGDEPSLLCSSPFEDATLSTLSAQLQDGGI 2433

  Fly  1521 --KQAGQ------------ADINVAIKNPKGKAMQPR-------LEEVSTGTYVVSFVPDECGTY 1564
              ::.||            ...:.|:| ..||....|       .|.::|...:...:.||  ..
  Rat  2434 FHEETGQKLLLNEAIAQGLVSSHTAVK-LMGKLNMFRGFFDSQTCESLTTEEVIDEGLMDE--KL 2495

  Fly  1565 QCSIKYGDKEIEG--SPFKLEAFPTGEAKKCKLVEQAP-------KIQTSGSQSHLKVDAREAGD 1620
            .|::...||.|.|  .|.........||....|:::..       ::.|.|.     ||.:....
  Rat  2496 LCNVLMSDKAISGILDPRTHSLCSVQEAVAAGLLDKETATRILEGQVITGGI-----VDLKRGKR 2555

  Fly  1621 GAVTC-------------------KITNKAGSE------------------------------IV 1636
            .:||.                   |.|...|:|                              .:
  Rat  2556 LSVTLASNLGLVDTTDQTELINLEKATKGRGAEKAVKERLIGLQMETTGLLDPESKAPLTVLQSI 2620

  Fly  1637 DIDVIEKDGFFDILYALN----DPG----------DYDINVKFG--GKDIPNGSFSIKAVESIEQ 1685
            |..:||::   :.:|.|.    |.|          ..|...|.|  |:|:      .:.:..:|.
  Rat  2621 DRGLIERE---EAIYQLTKQVLDGGIIHHISGLRLSVDNAFKHGMIGEDV------ARQLRKVEN 2676

  Fly  1686 YSHSEYIEEHTTKVV-----------------------------------QQTTQ---------- 1705
            ::|.::....|.:.:                                   |:.|.          
  Rat  2677 FNHHQFFHPQTKEALSFSEAIKLDLVSPDLKREIQEILDFSENLGDLIYGQKLTSVKANKEESLA 2741

  Fly  1706 ------SELVNGK------SEITYRSVA-------------FEKLPLPTTGGNVTAEVRMPS--- 1742
                  |.:::|.      :.|.|..:.             .|.:||......::.:|..||   
  Rat  2742 NKTALPSRVIHGVIDPESCTTIPYSELVKKCRIDIESGWRYLEVIPLSDIKDEMSNKVLTPSEAI 2806

  Fly  1743 --GKVDKPVI------QDNRDGTVSVKYDPREEGSHELVVKYNGEPVQGSPFKFHVDSITSGYVT 1799
              ||||...:      |.|..|.:.:....|...:..|..|...|.:........|  :|.|.:.
  Rat  2807 QRGKVDFGSMLKVLEAQANTGGIIDMATGKRVTLASALEQKLIDENMARIIASHQV--LTGGIID 2869

  Fly  1800 AY----------------GPGLTHGVTGEPANFTISTKGASAGGLTMAVEGP------SKADINY 1842
            .|                .|.|...:..:       |.|...|.....::|.      .||....
  Rat  2870 IYNDQRVTLNDAVEKRLISPELATMIQAD-------TLGKQGGTGVCELKGEFLRNEFRKATRES 2927

  Fly  1843 HDNK--DGTVSVQYLPTAPGEYQVSVRFGDKHIKGSPYFAKITGEGRKRNQISVGSCSEVTMPGD 1905
            :|.:  :|.:.|. ...|..:..|.|.:|.|..||.....::  ||:::::....|.:||     
  Rat  2928 YDKEKHEGVLQVG-SQCAQEKANVRVSYGVKVGKGKKISVEM--EGQRQDEEKASSDNEV----- 2984

  Fly  1906 ITDDDLRALNASIQAPSGLE----------EPCFLKRMPTGNIGISF-----TPREIGEHLVSVK 1955
                     :|||.:|.|||          .||      :|:..:..     :|....|..|:..
  Rat  2985 ---------SASIVSPGGLEGESTHQVLVTHPC------SGSSDLKLIEEARSPEVEQEEAVARM 3034

  Fly  1956 RLGKHINNSPFKVTVCEREVGDAKKV--KVSGTGLKEGQTHADNIFSVDTRNAGFG-------GL 2011
            ::..|:|.|...:     :.|:|:..  :|...|.:.....|..:.||...|...|       |.
  Rat  3035 KMTPHVNRSTPGL-----DAGEARDCPGRVGSKGQESKHEPAGKLSSVQAANVEVGRRGRRETGG 3094

  Fly  2012 SVSIE------GPSKAEI--QCTDKDDGTLNISYKPTEPGYYIVNLKFADHHVEG---------- 2058
            ...::      |||:.|:  :.|..|:   :.|:..::|...|.|    |...||          
  Rat  3095 EERVQTNKVAAGPSEEELDQEVTIGDE---HGSFVKSQPMKTIGN----DRGKEGGREKDFSLVC 3152

  Fly  2059 ------SPFTVKVA-----------GEGSN---------RKREKIQRERDAV----PI-TEIGSQ 2092
                  |..|.|.|           .||..         ::|||:.:|..::    |. :||...
  Rat  3153 KTEGFPSQMTFKDASLENQNALMFFSEGETKTVNLCSILKQREKLSQETASIVQKEPFSSEIPRP 3217

  Fly  2093 CKLTFK----------MPGITSFDLAACVTSPSNVTEDAEIQ------EVEDGLYAVHFVPKELG 2141
            .:|..:          ||.|:...:||.:|:....|::.::.      |.:|.::.         
  Rat  3218 ERLNSQESDGESHISDMPCISKGPMAAQITTRQETTDEQDLSITSKTAETKDRIFP--------- 3273

  Fly  2142 VHTVSVRYSEMHIPGSPFQFTVGPLRDSGSHLVKAGGSGLERGVVGEAAEFNVWTREAGG-GSLA 2205
                |..|.|..:...|...|       .:|.:|               |..|.|.:..| |.|.
  Rat  3274 ----SKNYKEKLLQEIPMDST-------RAHKLK---------------ESTVSTLDTEGLGYLD 3312

  Fly  2206 IS----VEGPSKADIEFKDRKDGSCDVSYKVTEPGEYRVGLKFNDRHIPDSPFKVYVSPDAGDA- 2265
            .|    :...|:||.||...:..      |:|...|.:              |...|:|...|| 
  Rat  3313 SSDIKALHEDSRADREFSGHQKS------KITTTQEVK--------------FLEVVNPLVRDAE 3357

  Fly  2266 -HK-----------------LEVQQFPQGNIQADAPYQFMVRKNGAKGELDAKIVAPSGTDDDCF 2312
             |:                 |..::.|.|..|::...|.           |..|:|.:       
  Rat  3358 GHRGSSKDRVAQRGPRTLASLLPEKLPAGTAQSENTKQH-----------DTVIIATT------- 3404

  Fly  2313 IQVIDGEMYSVRFYPRENGIHAIHVKFNGVHIPDSPFRIKVGKDVADPAAVH------------- 2364
                 .||       ||.         ..:.:|.||.::    |...|...|             
  Rat  3405 -----PEM-------REE---------MPLSLPCSPLKV----DEQIPKEKHKELPGDERASCMA 3444

  Fly  2365 -ASGNGLDEVKTGHKADFIINTCNAGVGTLAVSIDGPSKVAMDCTEVEEGYKVRYTPLLPGEHYI 2428
             .||.|.:.||..        .|.|........:         |.|.:|.. |.|..||......
  Rat  3445 TPSGKGSEGVKPA--------PCRATQNVFTRRL---------CLEHDEKL-VSYLSLLRDIEMR 3491

  Fly  2429 TVKYNNMHIVGSPFKVNATGDKLADEGAQETSTVIVETVQKV 2470
            |.:...:.:..:..:......|:.|...::.|||:.:.::.|
  Rat  3492 TKQIQPLELSVAELQDLLGQAKVLDRELKDLSTVVSQELECV 3533

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cherNP_001262659.2 CH_dFLNA-like_rpt1 175..297 CDD:409160
CH_dFLNA-like_rpt2 298..415 CDD:409164
IG_FLMN 432..527 CDD:214720
IG_FLMN 532..627 CDD:214720
IG_FLMN 631..724 CDD:214720
IG_FLMN 728..815 CDD:214720
IG_FLMN 821..913 CDD:214720 7/18 (39%)
IG_FLMN 918..1001 CDD:214720 21/120 (18%)
Filamin 1012..1098 CDD:395505 17/93 (18%)
IG_FLMN 1109..1196 CDD:214720 15/97 (15%)
Filamin 1197..1293 CDD:395505 25/129 (19%)
IG_FLMN 1302..1392 CDD:214720 24/107 (22%)
IG_FLMN 1395..1490 CDD:214720 17/95 (18%)
IG_FLMN 1494..1587 CDD:214720 25/158 (16%)
IG_FLMN 1606..1682 CDD:214720 21/140 (15%)
IG_FLMN <1731..1791 CDD:214720 14/70 (20%)
IG_FLMN 1797..1884 CDD:214720 19/110 (17%)
IG_FLMN 1978..2067 CDD:214720 26/132 (20%)
Filamin <2111..2159 CDD:395505 7/53 (13%)
IG_FLMN 2172..2260 CDD:214720 19/92 (21%)
IG_FLMN 2265..2354 CDD:214720 17/107 (16%)
IG_FLMN 2360..2448 CDD:214720 17/101 (17%)
IG_FLMN 2488..2577 CDD:214720
Macf1XP_063144057.1 None
Blue background indicates that the domain is not in the aligned region.

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